Caroline Wilde
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View article: PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma
PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma Open
The adhesion G-protein-coupled receptor GPR133 (ADGRD1) supports growth of the brain malignancy glioblastoma. How the extracellular interactome of GPR133 in glioblastoma modulates signaling remains unknown. Here, we use affinity proteomics…
View article: Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6
Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6 Open
GPR126/ADGRG6, a member of the adhesion G-protein-coupled receptor family, balances cell differentiation and proliferation through fine-tuning of intracellular cAMP levels, which is achieved through coupling to Gs and Gi proteins. While GP…
View article: The N Terminus of Adhesion G Protein–Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator
The N Terminus of Adhesion G Protein–Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator Open
The adhesion G protein–coupled receptor (aGPCR) GPR126/ADGRG6 plays an important role in several physiological functions, such as myelination or peripheral nerve repair. This renders the receptor an attractive pharmacological target. GPR12…
View article: PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM
PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM Open
GPR133 (ADGRD1), an adhesion G protein-coupled receptor, supports growth of glioblastoma, a brain malignancy. We demonstrated that GPR133 is intramolecularly cleaved, and that dissociation of its N-terminal and C-terminal fragments (NTF an…
View article: The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator
The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator Open
The adhesion G protein-coupled receptor (aGPCR) GPR126/ADGRG6 plays an important role in several physiological functions, such as myelination or peripheral nerve repair. This renders the receptor an attractive pharmacological target. GPR12…
View article: The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator
The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator Open
The adhesion G protein-coupled receptor (aGPCR) GPR126/ADGRG6 plays an important role in several physiological functions, such as myelination or peripheral nerve repair. This renders the receptor an attractive pharmacological target. GPR12…
View article: The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator
The N terminus of adhesion G protein-coupled receptor GPR126/ADGRG6 as allosteric force integrator Open
The adhesion G protein-coupled receptor (aGPCR) GPR126/ADGRG6 plays an important role in several physiological functions, such as myelination or peripheral nerve repair. This renders the receptor an attractive pharmacological target. GPR12…
View article: Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling
Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling Open
GPR133 (ADGRD1), an adhesion G protein-coupled receptor (GPCR) whose canonical signaling activates GαS-mediated generation of cytosolic cAMP, has been shown to be necessary for the growth of glioblastoma (GBM), a brain malignancy. The extr…
View article: Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling
Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signaling Open
SUMMARY GPR133 (ADGRD1), an adhesion G protein-coupled receptor (GPCR), is necessary for growth of glioblastoma (GBM), a brain malignancy. The extracellular N-terminus of GPR133 is thought to be autoproteolytically cleaved into an N-termin…
View article: <i>In vivo</i> identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development
<i>In vivo</i> identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development Open
Gpr126/Adgrg6, an adhesion family G protein–coupled receptor (aGPCR), is required for the development of myelinating Schwann cells in the peripheral nervous system. Myelin supports and insulates vertebrate axons to permit rapid signal prop…
View article: Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates
Ploidy Variation in Kluyveromyces marxianus Separates Dairy and Non-dairy Isolates Open
Kluyveromyces marxianus is traditionally associated with fermented dairy products, but can also be isolated from diverse non-dairy environments. Because of thermotolerance, rapid growth and other traits, many different strains are being de…
View article: Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133)
Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133) Open
Our results show that a broad spectrum of functionally relevant ADGRD1 variants is present in the human population which may cause clinically relevant phenotypes, while being compatible with life when heterozygous.
View article: Additional file 1: Table S1. of Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133)
Additional file 1: Table S1. of Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133) Open
Here, for all inspected nsSNPs descriptive informationâ s can be found (e.g. Ref. SNP accession numbers, Chr. position, genotype frequencies, references) as well as raw data of the functional analysis and degree of conservation. (XLSX 38 k…