Carolyn E. Arnold
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View article: Influence of dietary <i>Saccharomyces cerevisiae</i> fermentation product on markers of inflammation and cartilage metabolism in young exercising horses challenged with intra-articular lipopolysaccharide
Influence of dietary <i>Saccharomyces cerevisiae</i> fermentation product on markers of inflammation and cartilage metabolism in young exercising horses challenged with intra-articular lipopolysaccharide Open
The objective was to evaluate dietary Saccharomyces cerevisiae fermentation product (SCFP) on joint inflammation and cartilage metabolism in exercising yearlings challenged with intra-articular lipopolysaccharide (LPS), hypothesizing dieta…
View article: Mastectomy in ten mares: indications, surgical technique, complications, and long-term outcome
Mastectomy in ten mares: indications, surgical technique, complications, and long-term outcome Open
OBJECTIVE To describe the indications for and surgical technique of mastectomy of mares and to describe the outcome of 10 mares that underwent mastectomy in a retrospective case series. ANIMALS 10 mares having disease of one or both mammar…
View article: 109 Effectiveness of Fenbendazole in growing Quarter Horses using the Quantitative Modified Wisconsin Technique
109 Effectiveness of Fenbendazole in growing Quarter Horses using the Quantitative Modified Wisconsin Technique Open
Anthelmintics are commonly used in the equine industry to reduce parasite load, but there is a growing concern about anthelmintic resistance, especially in young horses where there is limited information available. Twenty-four, 2-yr-old Qu…
View article: 86 Evaluation of dietary <i>Saccharomyces cerevisiae</i> fermentation product on markers of joint inflammation in young, exercising horses following an intra-articular lipopolysaccharide challenge
86 Evaluation of dietary <i>Saccharomyces cerevisiae</i> fermentation product on markers of joint inflammation in young, exercising horses following an intra-articular lipopolysaccharide challenge Open
Including Saccharomyces cerevisiae fermentation product (SCFP) into the diets of young, exercising horses may prolong their performance career by optimizing the intra-articular environment. Our objective was to evaluate the effect of dieta…
View article: Effects of Clodronate Disodium on Endocrine Regulation of Bone Growth and Development in Exercising Yearling Horses
Effects of Clodronate Disodium on Endocrine Regulation of Bone Growth and Development in Exercising Yearling Horses Open
View article: PSIII-8 Extra-Label Bisphosphonate Effects on Intra-Articular Inflammation in Juvenile Horses Challenged with Intra-Articular Lipopolysaccharide
PSIII-8 Extra-Label Bisphosphonate Effects on Intra-Articular Inflammation in Juvenile Horses Challenged with Intra-Articular Lipopolysaccharide Open
Anecdotal assertions that bisphosphonates, such as clodronate disodium (CD), exhibit anti-inflammatory properties has led to extra-label use, despite a lack of scientific evidence of its efficacy. The objective of this study was to determi…
View article: PSVI-8 Bisphosphonate Pharmacokinetics in Juvenile Horses
PSVI-8 Bisphosphonate Pharmacokinetics in Juvenile Horses Open
Bisphosphonates alter bone metabolism via inhibition of osteoclastic bone resorption. Although bisphosphonates are beneficial to treat bone disease, extra-label use in healthy juvenile horses may interfere with normal bone metabolism. The …
View article: Negative pressure wound therapy for the management of surgical site infections with zoonotic, drug‐resistant pathogens on the upper body of the horse
Negative pressure wound therapy for the management of surgical site infections with zoonotic, drug‐resistant pathogens on the upper body of the horse Open
Summary This case series reviews the use of negative pressure wound therapy (NPWT) for surgical site infections (SSI) on the upper body of six horses at an academic referral institution between 2016 and 2020. The SSIs consisted of three ve…
View article: PSXV-14 Clodronate Use Does not Influence Physical Growth Parameters in Yearling Horses Undergoing Forced Exercise
PSXV-14 Clodronate Use Does not Influence Physical Growth Parameters in Yearling Horses Undergoing Forced Exercise Open
Off-label bisphosphonate use in juvenile horses is widespread despite little scientific understanding of biological and welfare impacts on skeletally immature, exercising horses. Therefore, the objective was to determine the effects of clo…
View article: Long-Term Outcome of Horses Undergoing Unilateral Mandibular Condylectomy and Meniscectomy for Temporomandibular Joint Disease
Long-Term Outcome of Horses Undergoing Unilateral Mandibular Condylectomy and Meniscectomy for Temporomandibular Joint Disease Open
Background There are no reports describing the long-term outcome of sport horses undergoing unilateral mandibular condylectomy with meniscectomy (UMC) for treatment for severe temporomandibular joint (TMJ) disease (TMD). Whether horses und…
View article: Equine enterocytes actively oxidize <scp>l</scp>-glutamine, but do not synthesize <scp>l</scp>-citrulline or <scp>l</scp>-arginine from <scp>l</scp>-glutamine or <scp>l</scp>-proline in vitro
Equine enterocytes actively oxidize <span>l</span>-glutamine, but do not synthesize <span>l</span>-citrulline or <span>l</span>-arginine from <span>l</span>-glutamine or <span>l</span>-proline in vitro Open
In livestock species, the enterocytes of the small intestine are responsible for the synthesis of citrulline and arginine from glutamine and proline. At present, little is known about de novo synthesis of citrulline and arginine in horses.…
View article: Responses to an intra-articular lipopolysaccharide challenge following dietary supplementation of<i>Saccharomyces cerevisiae</i>fermentation product in young horses
Responses to an intra-articular lipopolysaccharide challenge following dietary supplementation of<i>Saccharomyces cerevisiae</i>fermentation product in young horses Open
Dietary intervention may be a valuable strategy to optimize the intra-articular environment in young horses to prolong their performance career. To test the hypothesis that dietary supplementation of a Saccharomyces cerevisiae fermentation…
View article: The effects of xylazine or detomidine when used as a pre-anesthetic sedative on recovery quality and duration in horses undergoing elective equine castration.
The effects of xylazine or detomidine when used as a pre-anesthetic sedative on recovery quality and duration in horses undergoing elective equine castration. Open
The purpose of this prospective, blinded, randomized clinical trial was to compare the effects of low dose detomidine to xylazine on recovery quality and duration in a castration procedure. Horses were administered either detomidine [0.015…
View article: The effects of signalment, diet, geographic location, season, and colitis associated with antimicrobial use or <scp><i>Salmonella</i></scp> infection on the fecal microbiome of horses
The effects of signalment, diet, geographic location, season, and colitis associated with antimicrobial use or <span><i>Salmonella</i></span> infection on the fecal microbiome of horses Open
Background The fecal microbiome of healthy horses may be influenced by signalment, diet, environmental factors, and disease. Objectives To assess the effects of age, breed, sex, geographic location, season, diet, and colitis caused by anti…
View article: Alterations in the Fecal Microbiome and Metabolome of Horses with Antimicrobial-Associated Diarrhea Compared to Antibiotic-Treated and Non-Treated Healthy Case Controls
Alterations in the Fecal Microbiome and Metabolome of Horses with Antimicrobial-Associated Diarrhea Compared to Antibiotic-Treated and Non-Treated Healthy Case Controls Open
Diarrhea is an adverse effect of antimicrobial therapy in horses. This matched, case-controlled study compared the fecal microbiome and metabolome of horses on antibiotics that developed diarrhea (AAD, n = 17) to those that did not develop…
View article: Evaluation of the ocular surface mycobiota in clinically normal horses
Evaluation of the ocular surface mycobiota in clinically normal horses Open
The eye is host to myriad bacterial, fungal, and viral organisms that likely influence ocular surface physiology in normal and diseased states. The ocular surface mycobiota of horses has not yet been described using NGS techniques. This st…
View article: Donkey Epididymal Transport for Semen Cooling and Freezing
Donkey Epididymal Transport for Semen Cooling and Freezing Open
The objectives of this study were to assess the cooling and freezing of donkey epididymal semen harvested immediately after castration (Experiment 1, n = 4) or after the shipment (24 or 48 h) of epididymides attached to testicles (Experime…
View article: THE EQUINE FECAL MICROBIOME - EFFECTS OF DIET, ANTIMICROBIALS, AND COLITIS
THE EQUINE FECAL MICROBIOME - EFFECTS OF DIET, ANTIMICROBIALS, AND COLITIS Open
The microbiome of the equine gastrointestinal tract (GIT) form a symbiotic relationship with the horse, and play a critical role in nutrition, metabolism, and immunity. This work utilized 16S rRNA sequencing and metabolomics to characteriz…
View article: 114 Effects of aquatic conditioning in young horses. II. Bone metabolism
114 Effects of aquatic conditioning in young horses. II. Bone metabolism Open
While beneficial in rehabilitation, aquatic exercise effects on bone metabolism in young, healthy horses has not been investigated. Therefore, thirty Quarter Horse yearlings were stratified by age, body weight (BW), and sex and randomly as…
View article: 113 Effects of aquatic conditioning in young horses. I. Markers of inflammation and cartilage metabolism
113 Effects of aquatic conditioning in young horses. I. Markers of inflammation and cartilage metabolism Open
Aquatic treadmills improve range of motion and increase muscular strength in mature horses; however, effects of buoyancy on inflammation and cartilage metabolism in young horses are not well investigated. Therefore, thirty Quarter Horse ye…
View article: 66 Intra-articular lipopolysaccharide challenge has no long-term effects on inflammation and cartilage metabolism
66 Intra-articular lipopolysaccharide challenge has no long-term effects on inflammation and cartilage metabolism Open
Intra-articular lipopolysaccharide is a common model to induce acute synovitis to investigate the effects of various therapeutic agents or nutraceuticals. The long-term effects of intra-articular lipopolysaccharide use in skeletally mature…
View article: Effects of aquatic conditioning on cartilage and bone metabolism in young horses
Effects of aquatic conditioning on cartilage and bone metabolism in young horses Open
While beneficial in rehabilitation, aquatic exercise effects on cartilage and bone metabolism in young, healthy horses has not been well described. Therefore, 30 Quarter Horse yearlings (343 ± 28 kg; 496 ± 12 d of age) were stratified by a…
View article: Evaluation of the bacterial ocular surface microbiome in ophthalmologically normal dogs prior to and following treatment with topical neomycin-polymyxin-bacitracin
Evaluation of the bacterial ocular surface microbiome in ophthalmologically normal dogs prior to and following treatment with topical neomycin-polymyxin-bacitracin Open
The ocular surface microbiome of veterinary species has not been thoroughly characterized using molecular-based techniques, such as next generation sequencing (NGS), as the vast majority of studies have utilized traditional culture-based t…
View article: The cecal and fecal microbiomes and metabolomes of horses before and after metronidazole administration
The cecal and fecal microbiomes and metabolomes of horses before and after metronidazole administration Open
Antibiotic administration can be a cause of gastrointestinal disease in horses, creating a disruption in the normal population and function of bacteria found in the hindgut. The objective of this study was to describe the changes in the ce…
View article: Characterization of a Homozygous Deletion of Steroid Hormone Biosynthesis Genes in Horse Chromosome 29 as a Risk Factor for Disorders of Sex Development and Reproduction
Characterization of a Homozygous Deletion of Steroid Hormone Biosynthesis Genes in Horse Chromosome 29 as a Risk Factor for Disorders of Sex Development and Reproduction Open
Disorders of sex development (DSD) and reproduction are not uncommon among horses, though knowledge about their molecular causes is sparse. Here we characterized a ~200 kb homozygous deletion in chromosome 29 at 29.7–29.9 Mb. The region co…
View article: Evaluation of dietary trace mineral supplementation in young horses challenged with intra-articular lipopolysaccharide1
Evaluation of dietary trace mineral supplementation in young horses challenged with intra-articular lipopolysaccharide1 Open
Sixteen weanling Quarter Horses (255 ± 22 kg) were utilized in a 56-d trial to evaluate the effects of trace mineral (TM) source on intra-articular inflammation following a single acute inflammatory insult. Horses were stratified by age, s…
View article: Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin
Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin Open
The ocular surface microbiome of veterinary species has not been thoroughly characterized using next generation sequencing. Furthermore, alterations in the feline ocular surface microbiome over time or following topical antibiotic treatmen…
View article: Granulomatous Rhinitis in a Horse due to Mycobacterium intracellulare Infection
Granulomatous Rhinitis in a Horse due to Mycobacterium intracellulare Infection Open
View article: Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin
Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin Open
Next generation sequencing (NGS) studies have demonstrated a rich and diverse ocular surface-associated microbiota in people that was previously undetected by traditional culture-based methods. The ocular surface microbiome of horses has y…
View article: Effects of repeated arthrocentesis on systemic cytokine expression and leukocyte population in young horses challenged with intra-articular lipopolysaccharide
Effects of repeated arthrocentesis on systemic cytokine expression and leukocyte population in young horses challenged with intra-articular lipopolysaccharide Open
Osteoarthritis (OA) is a prevalent and economically costly source of lameness in the athletic horse. Previous studies investigating OA pathology have focused on localized trauma to the articular cartilage of a joint, largely ignoring the s…