Carolyn Costigan
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View article: Research and fellowship funding perspectives: A collective NIHR experience of a community of pre- and post-doctoral radiographers
Research and fellowship funding perspectives: A collective NIHR experience of a community of pre- and post-doctoral radiographers Open
Maximising research training opportunities, including research fellowships for the Radiography profession, will offer the completion of clinically relevant research projects alongside the development of the research leaders of the future.
View article: One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease
One Year of Gluten-Free Diet Impacts Gut Function and Microbiome in Celiac Disease Open
View article: One year of gluten free diet impacts gut function and microbiome in celiac disease
One year of gluten free diet impacts gut function and microbiome in celiac disease Open
BACKGROUND & AIMS Currently, the main treatment option for coeliac disease (CD) is a gluten free diet (GFD). This observational cohort study investigated the impact of CD and 1 year of GFD on gut function and microbiome. METHODS 36 newly d…
View article: The effect of depth context in the segmentation of the colon in MRI volumes
The effect of depth context in the segmentation of the colon in MRI volumes Open
Colonic volume content measurements can provide important information about the digestive tract physiology. Development of automated analyses will accelerate the translation of these measurements into clinical practice. In this paper, we t…
View article: Increased fasting small‐bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging
Increased fasting small‐bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging Open
Background and aims The regular overnight migrating motor complex (MMC) ensures that the normal fasting small‐bowel water content (SBWC) is minimised. We have applied our recently validated non‐invasive magnetic resonance technique to asse…
View article: Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects
Gastric motor and sensory function in health assessed by magnetic resonance imaging: Establishment of reference intervals for the Nottingham test meal in healthy subjects Open
Background Current investigations of gastric emptying rarely identify the cause of symptoms or provide a definitive diagnosis in patients with dyspepsia. This study assessed gastric function by magnetic resonance imaging (MRI) using the mo…
View article: Endotoxemia in Peritoneal Dialysis Patients: A Pilot Study to Examine the Role of Intestinal Perfusion and Congestion
Endotoxemia in Peritoneal Dialysis Patients: A Pilot Study to Examine the Role of Intestinal Perfusion and Congestion Open
Endotoxemia is common in advanced chronic kidney disease and is particularly severe in those receiving dialysis. In hemodialysis patients, translocation from the bowel occurs as a consequence of recurrent circulatory stress leading to a re…
View article: Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Syndrome Revealed by MRI
Distinct Abnormalities of Small Bowel and Regional Colonic Volumes in Subtypes of Irritable Bowel Syndrome Revealed by MRI Open
The constricted small bowel in IBS-nonC and the dilated transverse colon in IBS-C point to significant differences in underlying mechanisms of disease.
View article: Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial
Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial Open
View article: Colonic response to laxative ingestion as assessed by <scp>MRI</scp> differs in constipated irritable bowel syndrome compared to functional constipation
Colonic response to laxative ingestion as assessed by <span>MRI</span> differs in constipated irritable bowel syndrome compared to functional constipation Open
Background Functional constipation ( FC ) and irritable bowel syndrome with constipation ( IBS ‐C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging ( MRI ) technique to measure …
View article: Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non‐invasive imaging
Development and validation of a large, modular test meal with liquid and solid components for assessment of gastric motor and sensory function by non‐invasive imaging Open
Background Current investigations of stomach function are based on small test meals that do not reliably induce symptoms and analysis techniques that rarely detect clinically relevant dysfunction. This study introduces the large ‘Nottingha…
View article: Colon wall motility: comparison of novel quantitative semi‐automatic measurements using cine <scp>MRI</scp>
Colon wall motility: comparison of novel quantitative semi‐automatic measurements using cine <span>MRI</span> Open
Background Recently, cine magnetic resonance imaging ( MRI ) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective a…
View article: Fat Emulsion Intragastric Stability and Droplet Size Modulate Gastrointestinal Responses and Subsequent Food Intake in Young AdultsNitrogen
Fat Emulsion Intragastric Stability and Droplet Size Modulate Gastrointestinal Responses and Subsequent Food Intake in Young AdultsNitrogen Open
View article: A study of <i>T</i><sub>1</sub> relaxation time as a measure of liver fibrosis and the influence of confounding histological factors
A study of <i>T</i><sub>1</sub> relaxation time as a measure of liver fibrosis and the influence of confounding histological factors Open
Liver biopsy is the standard test for the assessment of fibrosis in liver tissue of patients with chronic liver disease. Recent studies have used a non‐invasive measure of T 1 relaxation time to estimate the degree of fibrosis in a single …
View article: Effect of experimental stress on the small bowel and colon in healthy humans
Effect of experimental stress on the small bowel and colon in healthy humans Open
Background Symptoms of irritable bowel syndrome ( IBS ) are frequently reported to be exacerbated by stress. Animal studies suggest that corticotrophin releasing hormone ( CRH ) mediates the effect of stress on the bowel. We have shown tha…
View article: Measurement of gastric meal and secretion volumes using magnetic resonance imaging
Measurement of gastric meal and secretion volumes using magnetic resonance imaging Open
MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus confounding of gastric emptying measurements by gastric secretions mixed with the tes…