Carrie B. Wiese
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View article: A genome-wide ATLAS of liver chromatin accessibility reveals that sex dictates diet-induced nucleosome dynamics
A genome-wide ATLAS of liver chromatin accessibility reveals that sex dictates diet-induced nucleosome dynamics Open
Summary The three-dimensional organization of the genome plays an important role in cellular function. Alterations between open and closed chromatin states contributes to DNA binding, collaborative transcriptional activities and informs po…
View article: The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation
The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation Open
The Four Core Genotypes (FCG) mouse model has become a valuable model to study the mechanistic basis for biological sex differences. This model allows discrimination between influences of gonadal sex (ovaries or testes) from those associat…
View article: X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction Open
Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired g…
View article: Gene Regulation and Mitochondrial Activity During White and Brown Adipogenesis Are Modulated by KDM5 Histone Demethylase
Gene Regulation and Mitochondrial Activity During White and Brown Adipogenesis Are Modulated by KDM5 Histone Demethylase Open
Body fat accumulation differs between males and females and is influenced by both gonadal sex (ovaries vs testes) and chromosomal sex (XX vs XY). We previously showed that an X chromosome gene, Kdm5c, is expressed at higher levels in femal…
View article: The impact of chromosomal sex on cardiometabolic health and disease
The impact of chromosomal sex on cardiometabolic health and disease Open
View article: <i>Sry</i>-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more
<i>Sry</i>-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more Open
Background Previous research on Four Core Genotypes and XY* mice has been instrumental in establishing important effects of sex-chromosome complement that cause sex differences in physiology and disease. We have generated rat models using …
View article: Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment Open
View article: Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment Open
Background Biological sex impacts susceptibility and presentation of cardiovascular disease, which remains the leading cause of death for both sexes. To reduce cardiovascular disease risk, statin drugs are commonly prescribed to reduce cir…
View article: X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction Open
Summary Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. We determined that f…
View article: Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease
Illuminating the Mechanisms Underlying Sex Differences in Cardiovascular Disease Open
Sex is a key risk factor for many types of cardiovascular disease. It is imperative to understand the mechanisms underlying sex differences to devise optimal preventive and therapeutic approaches for all individuals. Both biological sex (d…
View article: Additional file 1 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
Additional file 1 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment Open
Additional file 1. Table S1. PCR primers used in this study.
View article: Additional file 4 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
Additional file 4 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment Open
Additional file 4. Table S4. FCG gonadally-regulated genes compared to growth hormone regulated genes.
View article: Additional file 3 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
Additional file 3 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment Open
Additional file 3. Table S3. Pathway analyses for differentially expressed genes.
View article: Additional file 2 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment
Additional file 2 of Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment Open
Additional file 2. Table S2. Differentially expressed gene group comparisons.
View article: Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins
Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins Open
View article: X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity Open
Males and females differ in body composition and fat distribution. Using a mouse model that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that XX chromosome complement in combination with a high-fa…
View article: High-density lipoproteins induce miR-223–3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer
High-density lipoproteins induce miR-223–3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer Open
View article: Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis
Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis Open
View article: Migration pathways of sacral neural crest during development of lower urogenital tract innervation
Migration pathways of sacral neural crest during development of lower urogenital tract innervation Open
View article: An illustrated anatomical ontology of the developing mouse lower urogenital tract
An illustrated anatomical ontology of the developing mouse lower urogenital tract Open
Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects freq…