Richard E. Carson
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View article: Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT
Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT Open
Not applicable.
View article: Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [<sup>11</sup>C]UCB-J
Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [<sup>11</sup>C]UCB-J Open
[ 11 C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [ 11 C]UCB-J reference region (CS2mL); howeve…
Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates Open
The main inhibitory neurotransmitter in the central nervous system is γ-aminobutyric acid (GABA). GABA transporter type 1 (GAT-1) is the principal GABA transporter in the brain, and it plays a crucial role in modulating GABA signaling. Its…
View article: Fetal network controllability co-develops with synaptic development and synchronizes with maternal network controllability during pregnancy
Fetal network controllability co-develops with synaptic development and synchronizes with maternal network controllability during pregnancy Open
White matter undergoes rapid changes during the fetal period that are foundational for future cognitive functions. However, how these changes contribute to the brain’s capacity to support its dynamic activities—its controllability —remains…
View article: [<sup>18</sup>F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
[<sup>18</sup>F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury Open
Traumatic spinal cord injury (SCI) is a devastating neurologic condition lacking effective prognostic and treatment methods. PET imaging of synaptic vesicle glycoprotein 2A (SV2A) has been used in measuring synapse changes. We explore the …
Associations between fluid biomarkers and PET imaging ([11C]UCB‐J) of synaptic pathology in Alzheimer's disease Open
INTRODUCTION Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated the relatio…
View article: PET Imaging of Synaptic Density Loss in Patients with Multiple Sclerosis
PET Imaging of Synaptic Density Loss in Patients with Multiple Sclerosis Open
Synaptic loss is increasingly recognized as a key pathological feature in multiple sclerosis (MS), contributing to disease progression and cognitive dysfunction. Synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) im…
View article: Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease
Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease Open
INTRODUCTION Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated association…
View article: Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer’s disease
Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer’s disease Open
Background In mild cognitive impairment and dementia due to Alzheimer’s disease (AD), postmortem and in vivo neuroimaging studies have demonstrated significant neuronal loss in the basal forebrain cholinergic system (BFCS), which provides …
View article: A novel approach for modeling <i>in vivo</i> enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase
A novel approach for modeling <i>in vivo</i> enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase Open
PET imaging allows the study of enzyme concentration and activity in vivo . The enzyme natural turnover , relevant for drug development, can be estimated if a suicide inhibitor drug is used. The main aim of this study was to develop a mode…
Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography Open
Background Alcohol consumption at clinically relevant doses alters brain glutamate release. However, few techniques exist to measure these changes in humans. The metabotropic glutamate receptor 5 (mGluR5) PET radioligand [ 11 C]ABP688 is s…
Associations between fluid biomarkers and PET imaging ([<sup>11</sup>C]UCB-J) of synaptic pathology in Alzheimer’s disease Open
INTRODUCTION Positron Emission Tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer’s disease (AD). We investigate the relation…
View article: Network-based Molecular Constraints on in vivo Synaptic Density Alterations in Schizophrenia
Network-based Molecular Constraints on in vivo Synaptic Density Alterations in Schizophrenia Open
Converging neuroimaging, genetic, and post-mortem evidence highlights the fundamental role of synaptic density reductions in schizophrenia pathogenesis. However, the brain-wide spatial pattern of these alterations and the mechanisms underl…
Correcting <i>SUVR</i> bias by accounting for radiotracer clearance in tissue: A validation study with [ <sup>18</sup> F]FE-PE2I PET in cross-sectional, test-retest and longitudinal cohorts Open
Quantification of dopamine transporter (DAT) with [ 18 F]FE-PE2I PET is an important progression marker for Parkinson’s disease (PD). This study aimed to validate a novel correction ( SUVR c) for a less-biased estimate of SUVR by accountin…
View article: Lower Extremity Flow Quantification Using Dynamic ⁸²Rb PET: A Preclinical Investigation
Lower Extremity Flow Quantification Using Dynamic ⁸²Rb PET: A Preclinical Investigation Open
Accurate assessment of regional flow in the lower extremities is crucial for managing peripheral arterial disease (PAD) with critical limb ischemia. This study investigates dynamic 82Rb PET imaging with kinetic modeling for evaluating skel…
Development and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET Open
Phantoms are essential for assessing PET system performance, but most existing brain phantoms do not provide the anatomical fidelity required for the next-generation high-resolution PET systems. To address this limitation, we developed HYD…
View article: Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations
Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations Open
Quantitative molecular imaging with PET can offer insights into physiologic and pathologic processes and is widely used for studying brain disorders. The NeuroEXPLORER is a recently developed dedicated brain PET system offering high spatia…
Acute Alcohol-Induced Glutamate Changes Measured with Metabotropic Glutamate Receptor 5 Positron Emission Tomography Open
Background: Alcohol consumption at clinically relevant doses alters brain glutamate release. However, few techniques exist to measure these changes in humans. The metabotropic glutamate receptor 5 (mGluR5) PET radioligand [11C]ABP688 is se…
View article: Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study
Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study Open
Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD). Positron emission tomography (PET) studi…
View article: Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [<sup>11</sup>C]UCB-J PET
Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [<sup>11</sup>C]UCB-J PET Open
Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using S…
View article: Noise-aware Dynamic Image Denoising and Positron Range Correction for Rubidium-82 Cardiac PET Imaging via Self-supervision
Noise-aware Dynamic Image Denoising and Positron Range Correction for Rubidium-82 Cardiac PET Imaging via Self-supervision Open
Rb-82 is a radioactive isotope widely used for cardiac PET imaging. Despite numerous benefits of 82-Rb, there are several factors that limits its image quality and quantitative accuracy. First, the short half-life of 82-Rb results in noisy…
View article: Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia Open
Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely studied, despite evidence of peripheral immune dysfunction. Positron emission tomography brain imaging using the radiotracer [ 11 C]PBR28 was used to…