Carson C. Thoreen
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View article: Larp1 supports brain growth and spatial memory via post-transcriptional control of the translation machinery
Larp1 supports brain growth and spatial memory via post-transcriptional control of the translation machinery Open
In the brain, tight regulation of the translation of mRNAs is essential for development and plasticity. The translation machinery itself is largely encoded by mRNAs with terminal oligopyrimidine (TOP) motifs, which can be post-transcriptio…
View article: Quantitative profiling of human translation initiation reveals regulatory elements that potently affect endogenous and therapeutically modified mRNAs
Quantitative profiling of human translation initiation reveals regulatory elements that potently affect endogenous and therapeutically modified mRNAs Open
mRNA therapeutics offer a potentially universal strategy for the efficient development and delivery of therapeutic proteins. Current mRNA vaccines include chemically modified nucleotides to reduce cellular immunogenicity. Here, we develop …
View article: Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
MYC and YAP expression mediate drug resistance towards PI3K/mTOR inhibition.
View article: Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Structurally diverse PI3K/mTOR inhibitors induce MYC and YAP up-regulation in resistant MCAS-R cells.
View article: Supplmentary Figure S4 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplmentary Figure S4 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Both, p38/MAPK, and ERK/MEK pathway contribute to MYC and YAP up-regulation in resistant cell lines.
View article: Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Structurally diverse PI3K/mTOR inhibitors induce MYC and YAP up-regulation in resistant MCAS-R cells.
View article: Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure S2 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
MYC and YAP expression mediate drug resistance towards PI3K/mTOR inhibition.
View article: Supplementary Methods from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Methods from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Description of additional methods and procedures used in the study.
View article: Supplmentary Figure S4 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplmentary Figure S4 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Both, p38/MAPK, and ERK/MEK pathway contribute to MYC and YAP up-regulation in resistant cell lines.
View article: Data from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Data from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Aberrant activation of the PI3K/mTOR pathway is a common feature of many cancers and an attractive target for therapy, but resistance inevitably evolves as is the case for any cancer cell–targeted therapy. In animal tumor models, chronic i…
View article: Supplementary Figure Legends from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure Legends from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Legends for Supplementary Figures S1-S4.
View article: Supplementary Figure S3 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure S3 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
PI3K/mTOR inhibition leads to p38 activation and DNA damage response, which is suppressed in drug resistant cell lines.
View article: Supplementary Figure S3 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure S3 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
PI3K/mTOR inhibition leads to p38 activation and DNA damage response, which is suppressed in drug resistant cell lines.
View article: Supplementary Methods from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Methods from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Description of additional methods and procedures used in the study.
View article: Supplementary Figure Legends from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Supplementary Figure Legends from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Legends for Supplementary Figures S1-S4.
View article: Data from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP
Data from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Open
Aberrant activation of the PI3K/mTOR pathway is a common feature of many cancers and an attractive target for therapy, but resistance inevitably evolves as is the case for any cancer cell–targeted therapy. In animal tumor models, chronic i…
View article: Data from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Data from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival, and autophagy. Deregulation of the PI3K/Akt/mTOR signaling pathway occurs commonly in cancer and numerous inhibitors ta…
View article: Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
PDF file - 401K
View article: Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
PDF file - 719K, Supplemental figure 1. Torin2 on PC-3 wide type cell line, the IB was made after 30 min treatment of drug at indicated concentrations. Supplemental figure 2. Torin1, Torin2, AZD8055 and BEZ235 on HeLa and HCT-116 cell line…
View article: Supplementary Figure Legend and Tables 2 - 3 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Supplementary Figure Legend and Tables 2 - 3 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
PDF file - 69K
View article: Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Supplementary Figures 1 - 4 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
PDF file - 719K, Supplemental figure 1. Torin2 on PC-3 wide type cell line, the IB was made after 30 min treatment of drug at indicated concentrations. Supplemental figure 2. Torin1, Torin2, AZD8055 and BEZ235 on HeLa and HCT-116 cell line…
View article: Supplementary Figure Legend and Tables 2 - 3 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Supplementary Figure Legend and Tables 2 - 3 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
PDF file - 69K
View article: Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Supplementary Table 1 from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
PDF file - 401K
View article: Data from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Data from Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR Open
mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator of cell growth, survival, and autophagy. Deregulation of the PI3K/Akt/mTOR signaling pathway occurs commonly in cancer and numerous inhibitors ta…
View article: mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay
mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay Open
mRNA regulatory sequences control gene expression at multiple levels including translation initiation and mRNA decay. The 5′ terminal sequences of mRNAs have unique regulatory potential because of their proximity to key post-transcriptiona…
View article: mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay
mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay Open
mRNA regulatory sequences control gene expression at multiple levels including translation initiation and mRNA decay. The 5′ terminal sequences of mRNAs have unique regulatory potential because of their proximity to key post-transcriptiona…
View article: Measuring mRNA Decay with Roadblock‐qPCR
Measuring mRNA Decay with Roadblock‐qPCR Open
The control of mRNA stability is fundamental to gene regulation, and a deeper understanding of this post‐transcriptional regulatory step can provide key insights into gene function. Measuring mRNA half‐lives directly, however, is challengi…
View article: Roadblock-qPCR: a simple and inexpensive strategy for targeted measurements of mRNA stability
Roadblock-qPCR: a simple and inexpensive strategy for targeted measurements of mRNA stability Open
The stability of mRNAs is fundamental to determining expression level and dynamics. Nonetheless, current approaches for measuring transcript half-lives (e.g., transcription shutoff) are generally toxic or technically complex. Here we descr…
View article: Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.