Carsten Bokemeyer
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View article: Effective and safe use of immune checkpoint inhibitors for non‐small cell lung cancer in people living with <scp>HIV</scp>
Effective and safe use of immune checkpoint inhibitors for non‐small cell lung cancer in people living with <span>HIV</span> Open
Objectives With the near normalization of life expectancy in people living with HIV through antiretroviral therapy, the management of age‐related comorbidities has become increasingly important. Non‐AIDS‐defining cancers now contribute sig…
View article: Correction: Activity of CAR-T cells and bispecific antibodies in multiple myeloma with extramedullary involvement
Correction: Activity of CAR-T cells and bispecific antibodies in multiple myeloma with extramedullary involvement Open
View article: Chronological survival improvement over time with oxaliplatin-based chemotherapy plus targeted agents in metastatic colorectal cancer: An ARCAD database study
Chronological survival improvement over time with oxaliplatin-based chemotherapy plus targeted agents in metastatic colorectal cancer: An ARCAD database study Open
We demonstrated progressive improvements in survival outcomes for patients with metastatic colorectal cancer receiving first-line oxaliplatin-based chemotherapy plus molecular targeted agents. The findings highlight the importance of bioma…
View article: Hepatitis E virus infections in people with multiple myeloma: an emerging challenge in the era of immunotherapeutic approaches
Hepatitis E virus infections in people with multiple myeloma: an emerging challenge in the era of immunotherapeutic approaches Open
Hepatitis E virus (HEV) is an under-recognized cause of viral hepatitis, with rising incidence in high-income countries largely driven by zoonotic transmission. Patients with multiple myeloma (MM) are especially vulnerable to HEV, yet reco…
View article: Supplementary Table S4 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Table S4 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Table S4: List of antibodies used for Western blotting
View article: Supplementary Figure S4 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Figure S4 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Figure S4: Expression of GLUT-1 and GLUT-4 mRNA in different prostate cancer cell lines examined using RT-qPCR
View article: Supplementary Methods S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Methods S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Methods S2: Liquid chromatography−tandem mass spectrometry (LC-MS/MS)
View article: Supplementary Figure S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Figure S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Figure S1: Schema of the synthesis of naphthoquinone-thioglucoside conjugates
View article: Supplementary Figure S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Figure S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Figure S2: Effect of PeS-9 on AR-FL and AR-V7 mRNA expression in 22Rv1 cells
View article: Supplementary Table S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Table S2 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Table S2: Synthesized compounds
View article: Data from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Data from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
The Warburg effect is a shift from oxidative phosphorylation to anaerobic glycolysis, accompanied by an enormous increase in glucose uptake into cancer cells. We have utilized this effect to design a new group of targeted 1,4-naphthoquinon…
View article: Supplementary Methods S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Methods S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Methods S1: General synthetic procedures and methods used for synthesis
View article: Supplementary Table S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Table S1 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Table S1: Starting compounds used for the synthesis
View article: Supplementary Table S3 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Table S3 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Table S3: Spectral data of the synthesized compounds
View article: Supplementary Figure S5 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Figure S5 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Figure S5: Expression of GLUT-1 in different prostate cancer cell lines
View article: Supplementary Figure S3 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer
Supplementary Figure S3 from 6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer Open
Supplementary Figure S3: Effect of combinational treatment with PeS-9 and docetaxel in 22Rv1 prostate cancer cells
View article: A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients
A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients Open
Lymphomas, particularly aggressive non-Hodgkin lymphomas (NHL), remain challenging due to poor outcomes in a subset of patients who fail initial therapy. Current minimally invasive biomarkers for risk stratification need further improvemen…
View article: Professional grief among psycho-oncologists in Germany: A cross-sectional survey study
Professional grief among psycho-oncologists in Germany: A cross-sectional survey study Open
Background: Professional grief refers to the emotional response healthcare professionals may experience following patient deaths. Although likely relevant in clinical practice, this phenomenon has been largely overlooked in research - part…
View article: Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
Anticancer activity of triterpene glycosides from the sea star Solaster pacificus Open
Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C 1 and C 2 isolated from a sea star Solaster pacificus in prostate cancer models with varying drug resi…
View article: Activity of CAR-T cells and bispecific antibodies in multiple myeloma with extramedullary involvement
Activity of CAR-T cells and bispecific antibodies in multiple myeloma with extramedullary involvement Open
Extramedullary multiple myeloma (EMD) is associated with low response rates, short progression-free survival, and poor prognosis. CAR T cells and bispecific antibodies (bsABs) have shown efficacy in relapsed myeloma, but it remains uncerta…
View article: Cardiac biomarkers for risk stratification in newly diagnosed high-risk multiple myeloma in the GMMG-CONCEPT trial
Cardiac biomarkers for risk stratification in newly diagnosed high-risk multiple myeloma in the GMMG-CONCEPT trial Open
Cardiovascular adverse events (CVAE) are clinically relevant side effects during treatment with the proteasome inhibitor carfilzomib. We investigated the predictive value of cardiac biomarkers for onset of CVAE in patients with newly diagn…
View article: Response to Biologics in Patients With Early-Onset Treatment-Naïve Metastatic Colorectal Cancer—An Aide et Recherche en Cancérologie Digestive Database Analysis
Response to Biologics in Patients With Early-Onset Treatment-Naïve Metastatic Colorectal Cancer—An Aide et Recherche en Cancérologie Digestive Database Analysis Open
PURPOSE Colorectal cancer (CRC) incidence and mortality have decreased since the 1970s, but the incidence in young adults (<50 years, named early-onset CRC [eoCRC]) has been increasing. PATIENTS AND METHODS Individual patient data on 13,36…
View article: A qualitative interview study on psycho-oncologists’ experiences with patient deaths in Germany
A qualitative interview study on psycho-oncologists’ experiences with patient deaths in Germany Open
Despite regular exposure to patient deaths, little research has explored how psycho-oncologists experience and cope with these events. This study examined the unique challenges faced by psycho-oncologists in Germany, aiming to contribute t…
View article: A longitudinal analysis on alcohol consumption in patients with cancer undergoing psycho-oncological treatment
A longitudinal analysis on alcohol consumption in patients with cancer undergoing psycho-oncological treatment Open
View article: Streamlining and Accelerating the Molecular Tumor Board Process at the University Medical Center Hamburg-Eppendorf
Streamlining and Accelerating the Molecular Tumor Board Process at the University Medical Center Hamburg-Eppendorf Open
As the first open-source and extendable solution for standardized MTB documentation, MONOCLE enables wider adoption by other medical centers.
View article: Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation
Downregulation of S6 Kinase and Hedgehog–Gli1 by Inhibition of Fatty Acid Synthase in AML with FLT3-ITD Mutation Open
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy associated with a poor prognosis. Activating mutations in the FLT3 gene occur in approximately 30% of AML cases, with internal tandem duplications in the juxtamembran…
View article: Formerly Smoking and Currently Smoking Cancer Survivors’ View on Smoking Cessation – A Qualitative Study
Formerly Smoking and Currently Smoking Cancer Survivors’ View on Smoking Cessation – A Qualitative Study Open
Background Drastic life events, such as a cancer diagnosis, do not necessarily lead to a reduction in unhealthy and dysfunctional behaviors like smoking. Continued smoking among cancer survivors significantly increases the risk of recurren…
View article: Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization
Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization Open
Background/Objectives: In recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), the overall prognosis is poor, and systemic treatment options remain limited. While precision therapy approaches have revolutionized treatmen…
View article: Anticancer activity of triterpene glycosides from the sea star Solaster pacificus
Anticancer activity of triterpene glycosides from the sea star Solaster pacificus Open
Marine triterpene glycosides are known to exhibit significant anticancer activity. We investigated pacificusoside C and cucumariosides C1 and C2 isolated from a sea star Solaster pacificus in prostate cancer models wi…
View article: Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer Open