Carsten Deppermann
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View article: KDM6B inhibition modulates monocyte activation and alleviates IMQ-psoriasis skin inflammation
KDM6B inhibition modulates monocyte activation and alleviates IMQ-psoriasis skin inflammation Open
Inflammatory monocytes are increasingly recognized as key amplifiers of psoriasis, yet the epigenetic drivers of their pathogenic signature remain unclear. Here, we demonstrate that the histone demethylase KDM6B is markedly upregulated and…
View article: NOD2-Induced IκBζ Mediates a Protective Host Response against Epicutaneous Staphylococcus aureus Infection
NOD2-Induced IκBζ Mediates a Protective Host Response against Epicutaneous Staphylococcus aureus Infection Open
IκBζ, an atypical and largely unknown member of the IκB family, is a transcriptional coactivator of selective immune functions. In this study, we investigated the role of keratinocyte-derived IκBζ upon infection with a multidrug-resistant …
View article: Platelet life cycle during aging: function, production and clearance
Platelet life cycle during aging: function, production and clearance Open
Platelets are important players in hemostasis. Alterations in platelet number and/or function lead to life-threatening conditions like thrombosis, myocardial infarction and stroke. During aging, changes at the cellular, organ and systemic …
View article: Erratum to ‘Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress’ [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432]
Erratum to ‘Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress’ [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432] Open
[This corrects the article DOI: 10.1016/j.rpth.2024.102432.].
View article: Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress
Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress Open
Here, we present a series of illustrated capsules from the State of the Art (SOA) speakers at the 2024 International Society on Thrombosis and Haemostasis Congress in Bangkok, Thailand. This year's Congress marks the first time that the In…
View article: Macrophages and platelets in liver fibrosis and hepatocellular carcinoma
Macrophages and platelets in liver fibrosis and hepatocellular carcinoma Open
During fibrosis, (myo)fibroblasts deposit large amounts of extracellular matrix proteins, thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of hepatocyte function, portal hypertension, variceal bleeding…
View article: Intravital Imaging of Thrombosis Models in Mice
Intravital Imaging of Thrombosis Models in Mice Open
Intravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of thrombus formation and progression in vivo is studied after inflicting damage to the endothelium through mechanical, chemical, or laser injury. Mous…
View article: Platelet‐derived lipids promote insulin secretion of pancreatic β cells
Platelet‐derived lipids promote insulin secretion of pancreatic β cells Open
Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism.…
View article: Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation
Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation Open
There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the in…
View article: Intravital Imaging Allows Organ-Specific Insights Into Immune Functions
Intravital Imaging Allows Organ-Specific Insights Into Immune Functions Open
Leukocytes are among the most mobile and versatile cells that have many essential functions in homeostasis and survival. Especially cells from the innate immune system, i.e., neutrophils and macrophages, play an important role as rapid fir…
View article: Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation
Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation Open
Background Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality. Clinical and experimental data have revealed a role for neutrophil extracellular traps (NETs) in COV…
View article: Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and Neutrophils Extracellular Traps
Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and Neutrophils Extracellular Traps Open
Neutrophil extracellular traps (NETs) and polyphosphates (polyP) have been recognized as procoagulant polyanions. This review summarizes the activities and regulation of the two procoagulant mediators and compares their functions. NETs are…
View article: Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate Open
Polyphosphate is a procoagulant inorganic polymer of linear-linked orthophosphate residues. Multiple investigations have established the importance of platelet polyphosphate in blood coagulation; however, the mechanistic details of polypho…
View article: Immunothrombosis and thromboinflammation in host defense and disease
Immunothrombosis and thromboinflammation in host defense and disease Open
Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we revi…
View article: Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets
Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets Open
Every day, megakaryocytes produce billions of platelets that circulate for several days and eventually are cleared by the liver. The exact removal mechanism, however, remains unclear. Loss of sialic acid residues is thought to feature in t…
View article: Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination
Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination Open
Essentially all Staphylococcus aureus (S. aureus) bacteria that gain access to the circulation are plucked out of the bloodstream by the intravascular macrophages of the liver - the Kupffer cells. It is also thought that these bacteria are…
View article: Start a fire, kill the bug: The role of platelets in inflammation and infection
Start a fire, kill the bug: The role of platelets in inflammation and infection Open
Platelets are the main players in thrombosis and hemostasis; however they also play important roles during inflammation and infection. Through their surface receptors, platelets can directly interact with pathogens and immune cells. Platel…
View article: Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice
Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice Open
Key Points Platelet granule content is dispensable for maintaining vascular integrity during skin and lung inflammation. In stark contrast, lack of platelet granule secretion causes increased mortality in experimental stroke due to intracr…