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View article: AI redefines mass spectrometry chemicals identification: retention time prediction in metabolomics and for a Human Exposome Project
AI redefines mass spectrometry chemicals identification: retention time prediction in metabolomics and for a Human Exposome Project Open
The comprehensive identification of environmental and endogenous chemicals in human biospecimens is a critical bottleneck for realizing the Human Exposome Project. Untargeted metabolomics, particularly liquid chromatography–high-resolution…
View article: Emerging investigator series: release and phototransformation of benzophenone additives from polystyrene plastics exposed to sunlight
Emerging investigator series: release and phototransformation of benzophenone additives from polystyrene plastics exposed to sunlight Open
There are increasing concerns about the human and environmental health impacts of plastic exposure, which includes the risks associated with plastic additives.
View article: Solid-Phase Reactivity-Directed Extraction (SPREx): An Alternative Approach for Simultaneous Extraction, Identification, and Prioritization of Toxic Electrophiles Produced in Water Treatment Applications
Solid-Phase Reactivity-Directed Extraction (SPREx): An Alternative Approach for Simultaneous Extraction, Identification, and Prioritization of Toxic Electrophiles Produced in Water Treatment Applications Open
Current strategies to assess water quality are ineffective at prioritizing the most toxic chemicals within a treated water sample. Although it is well known that oxidation byproducts (OBPs) from water treatment processes (e.g., chlorinatio…
View article: (Non)targeted Chemical Analysis and Risk Assessment of Organic Contaminants in Darkibor Kale Grown at Rural and Urban Farms
(Non)targeted Chemical Analysis and Risk Assessment of Organic Contaminants in Darkibor Kale Grown at Rural and Urban Farms Open
This study investigated the presence and human hazards associated with pesticides and other anthropogenic chemicals identified in kale grown in urban and rural environments. Pesticides and related compounds (i.e., surfactants and metabolit…
View article: Extracting Structural Information from Physicochemical Property Measurements Using Machine Learning─A New Approach for Structure Elucidation in Non-targeted Analysis
Extracting Structural Information from Physicochemical Property Measurements Using Machine Learning─A New Approach for Structure Elucidation in Non-targeted Analysis Open
Non-targeted analysis (NTA) has made critical contributions in the fields of environmental chemistry and environmental health. One critical bottleneck is the lack of available analytical standards for most chemicals in the environment. Our…
View article: Bacteria exposed to antiviral drugs develop antibiotic cross-resistance and unique resistance profiles
Bacteria exposed to antiviral drugs develop antibiotic cross-resistance and unique resistance profiles Open
Antiviral drugs are used globally as treatment and prophylaxis for long-term and acute viral infections. Even though antivirals also have been shown to have off-target effects on bacterial growth, the potential contributions of antivirals …
View article: Characterizing the Chemical Landscape in Commercial E-Cigarette Liquids and Aerosols by Liquid Chromatography–High-Resolution Mass Spectrometry
Characterizing the Chemical Landscape in Commercial E-Cigarette Liquids and Aerosols by Liquid Chromatography–High-Resolution Mass Spectrometry Open
The surge in electronic cigarette (e-cig) use in recent years has raised questions on chemical exposures that may result from vaping. Previous studies have focused on measuring known toxicants, particularly those present in traditional cig…
View article: Enhanced Treatment of Municipal Wastewater Effluents by Fe-TAML/H<sub>2</sub>O<sub>2</sub>: Efficiency of Micropollutant Abatement
Enhanced Treatment of Municipal Wastewater Effluents by Fe-TAML/H<sub>2</sub>O<sub>2</sub>: Efficiency of Micropollutant Abatement Open
Combining iron with a tetraamido-macrocyclic ligand (Fe-TAML) as a catalyst and with hydrogen peroxide (H2O2) as the bulk oxidant is a process that has been suggested for the oxidative abatement of micropollutants during water treatment. I…
View article: Ozonation products of zidovudine and thymidine in oxidative water treatment
Ozonation products of zidovudine and thymidine in oxidative water treatment Open
Ozonation is an advanced treatment technology that is increasingly used for the removal of organic micropollutants from wastewater and drinking water. However, reaction of organic compounds with ozone can also result in the formation of to…
View article: Formation and Fate of Carbonyls in Potable Water Reuse Systems
Formation and Fate of Carbonyls in Potable Water Reuse Systems Open
Low molecular weight, uncharged compounds have been the subject of considerable study at advanced treatment plants employed for potable water reuse. However, previously identified compounds only account for a small fraction of the total di…
View article: Ring-Cleavage Products Produced during the Initial Phase of Oxidative Treatment of Alkyl-Substituted Aromatic Compounds
Ring-Cleavage Products Produced during the Initial Phase of Oxidative Treatment of Alkyl-Substituted Aromatic Compounds Open
Chemical oxidation with hydroxyl radical (HO•) and sulfate radical (SO4•-) is often used to treat water contaminated with aromatic compounds. Although oxidation of aromatics by these radicals has been studied for decades, the commonly acce…
View article: Exotic Electrophiles in Chlorinated and Chloraminated Water: When Conventional Kinetic Models and Reaction Pathways Fall Short
Exotic Electrophiles in Chlorinated and Chloraminated Water: When Conventional Kinetic Models and Reaction Pathways Fall Short Open
Halogenation and oxidation of organic matter in chlorinated and chloraminated water are typically attributed to the most abundant electrophiles present. This interpretation sometimes fails to explain laboratory observations, including halo…
View article: Chlorination of Phenols Revisited: Unexpected Formation of α,β-Unsaturated C<sub>4</sub>-Dicarbonyl Ring Cleavage Products
Chlorination of Phenols Revisited: Unexpected Formation of α,β-Unsaturated C<sub>4</sub>-Dicarbonyl Ring Cleavage Products Open
Despite decades of research on the fate of phenolic compounds when water is disinfected with hypochlorous acid (HOCl), there is still considerable uncertainty regarding the formation mechanisms and identity of ring cleavage products, espec…
View article: The exposome – a new approach for risk assessment
The exposome – a new approach for risk assessment Open
Complementing the human genome with an exposome reflects the increasingly obvious impact of environmental exposure, which far exceeds the role of genetics, on human health. Considering the complexity of exposures and, in addition, the reac…
View article: Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles
Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles Open
Lysine methylation is a common post-translational histone modification that regulates transcription and gene expression. The lysine residues in the histone tail also react with damaged nucleotides in chromatin, including abasic sites and N…
View article: Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light Open
Significance Phenols are common anthropogenic and natural chemicals that contaminate drinking water sources. To reduce exposure to these compounds, hydroxyl radicals are often used as chemical oxidants during water treatment. Although this…
View article: Trace Element Removal in Distributed Drinking Water Treatment Systems by Cathodic H<sub>2</sub>O<sub>2</sub> Production and UV Photolysis
Trace Element Removal in Distributed Drinking Water Treatment Systems by Cathodic H<sub>2</sub>O<sub>2</sub> Production and UV Photolysis Open
As water scarcity intensifies, point-of-use and point-of-entry treatment may provide a means of exploiting locally available water resources that are currently considered to be unsafe for human consumption. Among the different classes of d…
View article: Electrochemical Transformation of Trace Organic Contaminants in the Presence of Halide and Carbonate Ions
Electrochemical Transformation of Trace Organic Contaminants in the Presence of Halide and Carbonate Ions Open
Electrochemical treatment on anodes shows promise for the oxidation of organic contaminants in industrial wastewater and reverse osmosis concentrate from municipal wastewater recycling due to the high conductivity of the matrix and the con…
View article: Oxidation of Benzene by Persulfate in the Presence of Fe(III)- and Mn(IV)-Containing Oxides: Stoichiometric Efficiency and Transformation Products
Oxidation of Benzene by Persulfate in the Presence of Fe(III)- and Mn(IV)-Containing Oxides: Stoichiometric Efficiency and Transformation Products Open
Sulfate radical (SO4(•-)) is a strong, short-lived oxidant that is produced when persulfate (S2O8(2-)) reacts with transition metal oxides during in situ chemical oxidation (ISCO) of contaminated groundwater. Although engineers are aware o…