Carsten Spitzer
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Long-term consequences of soft political repression on psychological well-being, systemic inflammation and cellular ageing Open
Background As the global shift towards autocracy continues and soft political repression rises, it is crucial to understand its long-term health implications. Typical tactics of soft political repression are surveillance, denunciation and …
Dissociation in focus: replicating and extending network analytic insights based on the dissociative experiences scale Open
Background: Factor-analytic studies of the Dissociative Experiences Scale (DES) have reported between one- and seven-factor solutions, leaving its dimensional architecture unresolved. This inconsistency compromises the interpretability of …
View article: Long-term effectiveness of inpatient and day hospital treatment in departments of psychosomatic medicine and psychotherapy in Germany
Long-term effectiveness of inpatient and day hospital treatment in departments of psychosomatic medicine and psychotherapy in Germany Open
Background There is a lack of reliable data concerning the long-term effectiveness of psychosomatic inpatient and day hospital treatment in a naturalistic setting. The Multicenter Effectiveness Study of Inpatient and Day Hospital Treatment…
Shame‐related disorders in patients with atopic dermatitis and psoriasis – An exploratory, cross‐sectional interview study on the prevalence and correlates of body dysmorphic disorder and social anxiety disorder Open
Summary Background and objectives Atopic dermatitis (AD) and psoriasis (Pso) are frequently associated with psychological distress. This study evaluated the prevalence and correlates of shame‐related disorders (SRD), namely body dysmorphic…
View article: Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of <scp>PRS</scp> Moderation Effect: Findings From the <scp>PsyCourse</scp> Study
Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of <span>PRS</span> Moderation Effect: Findings From the <span>PsyCourse</span> Study Open
Introduction Bipolar disorder (BD) is a severe mental disorder characterized by extreme mood swings, often accompanied by metabolic comorbidities, such as cardiovascular disease, which increase mortality and reduce quality of life. Both me…
View article: Phenotypic and Genomic Associations of a Common Executive Function Factor and the p-Factor with the Big Five Personality Traits
Phenotypic and Genomic Associations of a Common Executive Function Factor and the p-Factor with the Big Five Personality Traits Open
A substantial number of patients with mental disorders struggle with goal-directed behavior. Both differences in personality and executive functions (EFs) are studied as potential mediators. On a latent level, EFs are highly heritable and …
View article: Implicit and Explicit Self-Concepts of Forgiveness in Women with Borderline Personality Disorder
Implicit and Explicit Self-Concepts of Forgiveness in Women with Borderline Personality Disorder Open
Background The tendency to forgive is associated with traits such as agreeableness and neuroticism, mental well-being, and interpersonal functioning. Given the high levels of aggression and interpersonal dysfunction in borderline personali…
Determinants of Quality of Life in Patients with Atopic Dermatitis and Psoriasis: A Multivariate Approach Open
Health-related quality of life (HRQoL) is reduced in atopic dermatitis and psoriasis. Several factors impact HRQoL including sociodemographic and skin disease-related characteristics, health behaviours, cardiometabolic comorbidities, and p…
View article: Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection
Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection Open
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to hav…
View article: Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders
Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders Open
Micro RNAs (miRNAs) play a crucial role as regulators of various biological processes and have been implicated in the pathogenesis of mental disorders such as schizophrenia and bipolar disorders. In this study, we investigate the expressio…
Antagonistic Narcissism in Women with Borderline Personality Disorder: A Case-Control Study Open
Objective: Borderline personality disorder (BPD) is characterized by instability in self-image, emotions, and relationships. Features such as (auto)aggression, devaluation, and impulsivity indicate proximity to narcissistic traits, especia…
View article: How variants in inflammatory mediator genes influence symptom severity of psychiatric disorders: Findings from the PsyCourse study
How variants in inflammatory mediator genes influence symptom severity of psychiatric disorders: Findings from the PsyCourse study Open
Alterations in glial cell function and cytokine levels in the central nervous system may be influenced by neuroinflammatory processes, which have a pathogenic role in psychiatric disorders. Variability in genes that encode inflammatory med…
Facets of shame and their impact on quality of life in patients with atopic dermatitis and psoriasis Open
Background: Shame is a complex emotion with different facets. Skin shame is a specific aspect of body shame, which involves the skin perceived as inferior or flawed. Its role in atopic dermatitis (AD) and psoriasis is not well investigated…
View article: Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines
Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines Open
Importance Numerous studies indicate that the traditional categorical classification of severe mental disorders (SMD), such as schizophrenia, bipolar disorders, and major depressive disorders, does not align with the underlying biology of …
View article: Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study
Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study Open
Although lipid biology may play a key role in the pathophysiology of mental health disorders such as schizophrenia (SCZ) and bipolar disorder (BD), the nature of this interplay and how it could shape phenotypic presentation, including cogn…
View article: Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder
Pathway-Specific Polygenic Scores for Lithium Response for Predicting Clinical Lithium Treatment Response in Patients with Bipolar Disorder Open
Background Polygenic scores (PGSs) hold the potential to identify patients who respond favourably to specific psychiatric treatments. However, their biological interpretations remain unclear. In this study, we developed pathway-specific PG…
Social inhibition in depressed patients is associated with an altered activation profile of the interleukin-6-inducible transcription factor STAT3 Open
These findings point towards a possible relationship between STAT3 signaling and social inhibition in depressed patients.
View article: Personality Functioning in Inpatients With Eating Disorders: Association With Symptom Severity and Treatment Outcome
Personality Functioning in Inpatients With Eating Disorders: Association With Symptom Severity and Treatment Outcome Open
Objective Impairment in personality functioning (PF) has been linked to a number of mental disorders, including eating disorders (EDs). However, the precise relationship between PF and symptom severity, as well as the potential impact on o…
Transference-focused psychotherapy in an inpatient setting for borderline personality disorders: changes in symptomatology Open
This prospective, naturalistic, longitudinal study examined changes in borderline-specific symptoms in a six-month, manual-based transference-focused psychotherapy (TFP) inpatient treatment for patients with borderline personality disorder…
Nudging: An experiment on transparency, accounting for reactance and response time Open
Is being informed about a nudge detrimental to its effect? This paper reports results from an experimental online study testing the effects of transparency on the effectiveness of a default nudge while accounting for psychological reactanc…
Towards Automated Classification of Adult Attachment Interviews in German Language Using the BERT Language Model Open
Attachment theory, pioneered by John Bowlby, has become a prominent psychological framework that aids in our comprehension of human behavior within close relationships. The Adult Attachment Interview (AAI), a semi-structured interview, pro…
View article: Lost and found: dynamics of relationship and employment status over time in people with affective and psychotic spectrum disorders
Lost and found: dynamics of relationship and employment status over time in people with affective and psychotic spectrum disorders Open
Background Employment and relationship are crucial for social integration. However, individuals with major psychiatric disorders often face challenges in these domains. Aims We investigated employment and relationship status changes among …
Unravelling inter‐relations within and between psychodynamic constructs and psychopathology using network analysis Open
Abstarct Psychodynamic constructs and psychopathology are closely inter‐related, but more detailed insight is needed. We investigated these complex inter‐relations using network analysis. A Gaussian graphical model in a sample of N = 2232 …
Differential constellations of dissociative symptoms and their association with childhood trauma – a latent profile analysis Open
Background: While several studies documented a positive correlation between childhood maltreatment severity and dissociation severity, it is currently unknown whether specific dissociative symptoms cluster together among individuals with c…