Chunlai Li
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View article: Remimazolam alleviates cerebral ischemia–reperfusion injury of rats by inhibiting NF-κB/NLRP3 inflammasome pyroptosis
Remimazolam alleviates cerebral ischemia–reperfusion injury of rats by inhibiting NF-κB/NLRP3 inflammasome pyroptosis Open
Neuroinflammation is closely associated with activation of NLRP3 inflammasome after acute ischemic stroke. Our previous study preliminarily found that remimazolam mitigated cerebral ischemia-reperfusion (I/R) injury in MCAO rats, possibly …
View article: Correlation of <i>APOE</i>, <i>SLCO1B1</i> and <i>LPA KIV-2</i> gene polymorphisms with coronary heart disease in the Teochew population
Correlation of <i>APOE</i>, <i>SLCO1B1</i> and <i>LPA KIV-2</i> gene polymorphisms with coronary heart disease in the Teochew population Open
BACKGROUND Coronary heart disease (CHD) is a prominent cause of mortality and disability worldwide. Like most complex diseases, the risk of CHD in individuals is regulated by the interaction between genetic factors and lifestyle. APOE and …
View article: Formation of Cones within the Zhurong Landing Area
Formation of Cones within the Zhurong Landing Area Open
On May 15, 2021, China’s first Mars exploration mission, Tianwen-1 (TW-1), successfully landed its Zhurong rover in the southern Utopia Planitia on Mars. Pitted cones, a characteristic feature of both Utopia Planitia and the landing …
View article: The Frequency Response Characteristics of Ge-on-Si Photodetectors Under High Incident Power
The Frequency Response Characteristics of Ge-on-Si Photodetectors Under High Incident Power Open
This study explores the mechanisms responsible for the bandwidth reduction observed in germanium photodetectors under high signal light power. We investigate the impact of the carrier-shielding effect on the bandwidth through simulations, …
View article: The Frequency Response Characteristics of Ge-on-Si Photodetectors Under High Incident Power
The Frequency Response Characteristics of Ge-on-Si Photodetectors Under High Incident Power Open
This study explores the mechanisms responsible for the bandwidth reduction observed in Ge-on-Si photodetectors under high incident light power. We investigate the impact of the carrier-screening effect on the bandwidth through simulations,…
View article: Directionally asymmetric nonlinear optics in planar chiral MnTiO$_3$
Directionally asymmetric nonlinear optics in planar chiral MnTiO$_3$ Open
Planar chiral structures possess a two dimensional handedness that is associated with broken mirror symmetry. Such motifs span vast length scales; examples include certain pinwheel molecules, nautilus shells, cyclone wind patterns and spir…
View article: Experiencing anesthesia and surgery early in life impairs cognitive and behavioral development
Experiencing anesthesia and surgery early in life impairs cognitive and behavioral development Open
Background The impact of anesthesia and surgery on neurocognitive and behavioral development in infants and children remains inadequately understood. Objective To investigate the impact of early-life exposure to general anesthesia and surg…
View article: Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro [Retraction]
Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro [Retraction] Open
[This retracts the article DOI: 10.2147/DDDT.S398464.].
View article: Construction of a predictive model for blood transfusion in patients undergoing total hip arthroplasty and identification of clinical heterogeneity
Construction of a predictive model for blood transfusion in patients undergoing total hip arthroplasty and identification of clinical heterogeneity Open
A precise forecast of the need for blood transfusions (BT) in patients undergoing total hip arthroplasty (THA) is a crucial step toward the implementation of precision medicine. To achieve this goal, we utilized supervised machine learning…
View article: High-Performance Hybrid Phototheranostics for NIR-IIb Fluorescence Imaging and NIR-II-Excitable Photothermal Therapy
High-Performance Hybrid Phototheranostics for NIR-IIb Fluorescence Imaging and NIR-II-Excitable Photothermal Therapy Open
Photothermal therapy operated in the second near-infrared (NIR-II, 1000–1700 nm) window and fluorescence imaging in the NIR-IIb (1500–1700 nm) region have become the most promising techniques in phototheranostics. Their combination enables…
View article: Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro
Antitumor Effects of Hydromorphone on Human Gastric Cancer Cells in vitro Open
Hydromorphone suppresses the proliferation of human GC cells in a dose- and time-dependent manner. That may provide a theoretical basis for the clinical application of hydromorphone in the safe and effective treatment of GC.
View article: Supplementary Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer
Supplementary Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer Open
Supplementary Figure and Supplementary Figure legend
View article: Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer
Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer Open
Long noncoding RNA (lncRNA) is yet to be linked to cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA is associated with the …
View article: Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer
Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer Open
Long noncoding RNA (lncRNA) is yet to be linked to cancer metabolism. Here, we report that upregulation of the lncRNA LINC00538 (YIYA) promotes glycolysis, cell proliferation, and tumor growth in breast cancer. YIYA is associated with the …
View article: Supplementary Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer
Supplementary Data from Expression of Long Noncoding RNA <i>YIYA</i> Promotes Glycolysis in Breast Cancer Open
Supplementary Figure and Supplementary Figure legend
View article: Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design
Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design Open
Selective CDK2 inhibitors have the potential to provide effective therapeutics for CDK2-dependent cancers and for combating drug resistance due to high cyclin E1 (CCNE1) expression intrinsically or CCNE1 amplification induced by treatment …
View article: Propofol pretreatment attenuates glutamate induced excitotoxicity of astrocytes via the p90RSK / Bcl-2 signaling pathway
Propofol pretreatment attenuates glutamate induced excitotoxicity of astrocytes via the p90RSK / Bcl-2 signaling pathway Open
Propofol is a short acting anesthetic which can be used in neurosurgery and interventional surgery requiring anesthesia or sedation. Previous studies have suggested that glutamate has a toxic effect on astrocytes, while propofol has a prot…
View article: Study of the effect of pain on postoperative rehabilitation of patients with uterine malignant tumor
Study of the effect of pain on postoperative rehabilitation of patients with uterine malignant tumor Open
Objective The relationship between acute postoperative pain (APSP) and health-related quality of life (HRQoL) in patients with uterine malignant tumor after operation was evaluated with self-rating scales, and the influencing factors of po…
View article: The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway
The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway Open
Propofol (100 µM)-induced mitochondrial damage in fetal rat hippocampal neurons may be mediated by the AMPK/p53 signaling pathway. Propofol (100 µM) was shown to inhibit the activity of AMPK in neurons, upregulate the expression of p53, an…
View article: Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows Open
Background In highly intensive dairy farms, cows often suffer from metabolic disorders that cause severe oxidative stress. Objectives This study aimed to observe correlations and associations of oxidative stress‐related indicators with mil…
View article: A noncoding RNA modulator potentiates phenylalanine metabolism in mice
A noncoding RNA modulator potentiates phenylalanine metabolism in mice Open
RNA solution for a genetic problem Phenylketonuria provides a classic case of the benefit of newborn metabolic screening: It is a single-gene disease that can be detected at birth, and its neurological effects can be prevented by dietary t…
View article: Efficacy and safety of dexmedetomidine in patients receiving mechanical ventilation: Evidence from randomized controlled trials
Efficacy and safety of dexmedetomidine in patients receiving mechanical ventilation: Evidence from randomized controlled trials Open
At present, the efficacy and safety of dexmedetomidine in patients receiving mechanical ventilation (MV) is still controversial. Therefore, the purpose of this research was to assess the efficacy and safety of dexmedetomidine in MV patient…
View article: Exogenous morphine inhibits the growth of human gastric tumor in vivo
Exogenous morphine inhibits the growth of human gastric tumor in vivo Open
Morphine is commonly used to relieve severe pain that is often associated with cancer. Previous studies have found that morphine could affect cancer development; however, this effect is poorly understood. To further clarify the anti-cancer…