Casey M. Wright
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View article: Supplementary Methods, Figures S1 - S14, Tables S1, S3 - S10 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Supplementary Methods, Figures S1 - S14, Tables S1, S3 - S10 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling Open
Supplementary Information includes: Supplementary Methods providing additional information on experimental techniques and data analysis; Supplementary Figures S1-S14 providing critical control experiments and raw data analyses for experime…
View article: Supplementary Table S2 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Supplementary Table S2 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling Open
Intensity ratios of methylated to unmethylated DNA for TSG promoters in paired primary hLSCC (LC) and normal lung squamous cell (NL) samples from 18 individuals.
View article: Data from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Data from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling Open
To discover new tumor-suppressor genes (TSG), we developed a functional genomics approach in which immortalized but nontumorigenic cells were stably transduced with large-scale shRNA pools and tested for tumor formation in mice. Identifica…
View article: Data from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Data from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling Open
To discover new tumor-suppressor genes (TSG), we developed a functional genomics approach in which immortalized but nontumorigenic cells were stably transduced with large-scale shRNA pools and tested for tumor formation in mice. Identifica…
View article: Supplementary Table S2 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Supplementary Table S2 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling Open
Intensity ratios of methylated to unmethylated DNA for TSG promoters in paired primary hLSCC (LC) and normal lung squamous cell (NL) samples from 18 individuals.
View article: Supplementary Methods, Figures S1 - S14, Tables S1, S3 - S10 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling
Supplementary Methods, Figures S1 - S14, Tables S1, S3 - S10 from A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling Open
Supplementary Information includes: Supplementary Methods providing additional information on experimental techniques and data analysis; Supplementary Figures S1-S14 providing critical control experiments and raw data analyses for experime…
View article: Regulatory T Cells Induced by Single-Peptide Liposome Immunotherapy Suppress Islet-Specific T Cell Responses to Multiple Antigens and Protect from Autoimmune Diabetes
Regulatory T Cells Induced by Single-Peptide Liposome Immunotherapy Suppress Islet-Specific T Cell Responses to Multiple Antigens and Protect from Autoimmune Diabetes Open
Ag-specific tolerizing immunotherapy is considered the optimal strategy to control type 1 diabetes, a childhood disease involving autoimmunity toward multiple islet antigenic peptides. To understand whether tolerizing immunotherapy with a …
View article: Genomic Deletion of BAP1 and CDKN2A Are Useful Markers for Quality Control of Malignant Pleural Mesothelioma (MPM) Primary Cultures
Genomic Deletion of BAP1 and CDKN2A Are Useful Markers for Quality Control of Malignant Pleural Mesothelioma (MPM) Primary Cultures Open
Malignant pleural mesothelioma (MPM) is a deadly cancer that is caused by asbestos exposure and that has limited treatment options. The current standard of MPM diagnosis requires the testing of multiple immunohistochemical (IHC) markers on…
View article: Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota Open
Following publication of the original article [1] it came to the attention of the Production Editor that Figs. 1 and 2 had not been replaced with the newly revised figures supplied by the authors (the originals being unusable due to poor q…
View article: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota Open
These findings demonstrate for the first time that type 1 diabetes-associated genetic variants that restore immune tolerance to islet antigens also result in functional changes in the gut immune system and resultant changes in the microbio…
View article: Additional file 2: Table S1. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
Additional file 2: Table S1. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota Open
OTU associations with IL-2/Treg pathway risk alleles. Related to Fig. 7. (XLSX 67 kb)
View article: Additional file 4: Table S3. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
Additional file 4: Table S3. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota Open
T1D-associated SNPs used for risk score calculation. Related to Fig. 7. (XLSX 49 kb)
View article: Additional file 3: Table S2. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
Additional file 3: Table S2. of Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota Open
OTU associations with all T1D-associated risk alleles. Related to Fig. 7. (XLSX 61 kb)
View article: Progenitor genotyping reveals a complex clonal architecture in a subset of <i><scp>CALR</scp>‐</i>mutated myeloproliferative neoplasms
Progenitor genotyping reveals a complex clonal architecture in a subset of <i><span>CALR</span>‐</i>mutated myeloproliferative neoplasms Open
Summary The identification of acquired CALR mutations in patients with essential thrombocythaemia ( ET ) or myelofibrosis ( MF ) has meant that disease‐initiating mutations can now be detected in about 90% of all patients with a myeloproli…
View article: Real‐life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria
Real‐life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria Open
Summary Background Omalizumab (Xolair) dosing in severe allergic asthma is based on serum IgE and bodyweight. In Australia, patients eligible for omalizumab but exceeding recommended ranges for IgE (30–1500 IU/mL) and bodyweight (30–150 kg…
View article: KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma
KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma Open
These functional data implicating KCa1.1 in MPM cell migration support our integrative approach using MPM gene expression datasets to identify novel and potentially druggable targets.
View article: A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma
A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma Open
Low circulating SPARC was associated with favourable prognosis. Secreted protein acidic and rich in cysteine was present in both tumour cells and stromal fibroblasts; and our in vitro and in vivo experiments suggest that stromal fibroblast…
View article: Additional file 1: Table S1. of KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma
Additional file 1: Table S1. of KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma Open
Top 20 Enriched microRNA Families Extracted from the Four Gene Expression Datasets. Table S2. Pathway Enrichment Analysis of Gene Targets of the miR-17 family members. Table S3. Primers and TaqMan Assay IDs for RT-qPCR and siRNA and Mimic …