Casey S. Lee
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View article: Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis
Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis Open
Significance Myasthenia gravis is caused by autoantibodies, which target postsynaptic proteins, primarily the acetylcholine receptor, that inhibit neuromuscular signaling. The myasthenia gravis thymus can serve as a reservoir of acetylchol…
View article: Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production
Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production Open
Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of the CNS that are primarily characterized by severe inflammation of the spinal cord and optic nerve. Approximately 75% of NMOSD patients harbour circula…
View article: Circulating plasmablasts are elevated and produce pathogenic anti‐endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension
Circulating plasmablasts are elevated and produce pathogenic anti‐endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension Open
Idiopathic pulmonary arterial hypertension (IPAH) is a devastating pulmonary vascular disease in which autoimmune and inflammatory phenomena are implicated. B cells and autoantibodies have been associated with IPAH and identified as potent…
View article: Compromised fidelity of B‐cell tolerance checkpoints in AChR and MuSK myasthenia gravis
Compromised fidelity of B‐cell tolerance checkpoints in AChR and MuSK myasthenia gravis Open
The results indicate that both these MG subtypes harbor defects in central and peripheral B cell tolerance checkpoints. Defective B cell tolerance may represent a fundamental contributor to autoimmunity in MG and is of particular importanc…