Casey Trimmer
YOU?
Author Swipe
View article: Identifying candidate genes underlying isolated congenital anosmia
Identifying candidate genes underlying isolated congenital anosmia Open
An estimated 1 in 10 000 people are born without the ability to smell, a condition known as congenital anosmia, and about one third of those people have non‐syndromic, or isolated congenital anosmia (ICA). Despite the significant impact of…
View article: Supplementary Tables 1-2, Figures 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Supplementary Tables 1-2, Figures 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Supplementary Tables 1-2, Figures 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
View article: Data from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Data from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1 in several …
View article: Supplementary Tables 1-2, Figures 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Supplementary Tables 1-2, Figures 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Supplementary Tables 1-2, Figures 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
View article: Supplementary Figure 1 from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Supplementary Figure 1 from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration Open
PDF file - 105K
View article: Supplementary Methods from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Supplementary Methods from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Supplementary Methods from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
View article: Supplementary Methods from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Supplementary Methods from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Supplementary Methods from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
View article: Supplementary Figure Legends 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Supplementary Figure Legends 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Supplementary Figure Legends 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
View article: Supplementary Figure Legend from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Supplementary Figure Legend from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration Open
PDF file - 72K
View article: Supplementary Figure 1 from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Supplementary Figure 1 from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration Open
PDF file - 105K
View article: Supplementary Figure Legend from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Supplementary Figure Legend from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration Open
PDF file - 72K
View article: Data from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Data from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration Open
Both cell-autonomous and non–cell-autonomous factors contribute to tumor growth and metastasis of melanoma. The function of caveolin-1 (Cav1), a multifunctional scaffold protein known to modulate several biologic processes in both normal t…
View article: Data from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Data from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1 in several …
View article: Supplementary Figure Legends 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
Supplementary Figure Legends 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway Open
Supplementary Figure Legends 1-2 from CAV1 Inhibits Metastatic Potential in Melanomas through Suppression of the Integrin/Src/FAK Signaling Pathway
View article: Data from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration
Data from Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial Migration Open
Both cell-autonomous and non–cell-autonomous factors contribute to tumor growth and metastasis of melanoma. The function of caveolin-1 (Cav1), a multifunctional scaffold protein known to modulate several biologic processes in both normal t…
View article: Allosteric modulation of a human odorant receptor
Allosteric modulation of a human odorant receptor Open
Odor perception is first determined by how the myriad of environmental volatiles are detected at the periphery of the olfactory system. The combinatorial activation of dedicated odorant receptors generates enough encoding power for the dis…
View article: Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks
Genetic variation in the human olfactory receptor OR5AN1 associates with the perception of musks Open
Humans have significant individual variations in odor perception, derived from their experience or sometimes from differences in the olfactory receptor (OR) gene repertoire. In several cases, the genetic variation of a single OR affects th…
View article: Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities
Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities Open
The chemical senses of taste and smell play a vital role in conveying information about ourselves and our environment. Tastes and smells can warn against danger and also contribute to the daily enjoyment of food, friends and family, and ou…
View article: Odorant Receptor Inhibition is Fundamental to Odor Encoding
Odorant Receptor Inhibition is Fundamental to Odor Encoding Open
SUMMARY Most natural odors are complex mixtures of many volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose. To date surprisingly little is known about how OR antagonism …
View article: A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans Open
Comparative transcriptomics of olfactory mucosae offers clues into the putative functions of highly abundant ORs in mammals.
View article: Genetic variation across the human olfactory receptor repertoire alters odor perception
Genetic variation across the human olfactory receptor repertoire alters odor perception Open
Humans use a family of more than 400 olfactory receptors (ORs) to detect odors, but there is currently no model that can predict olfactory perception from receptor activity patterns. Genetic variation in human ORs is abundant and alters re…
View article: A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans Open
The mammalian olfactory system displays species-specific adaptations to different ecological niches. To investigate the evolutionary dynamics of olfactory sensory neuron (OSN) sub-types across 95 million years of mammalian evolution, we ap…
View article: Genetic variation across the human olfactory receptor repertoire alters odor perception
Genetic variation across the human olfactory receptor repertoire alters odor perception Open
The human olfactory receptor repertoire is characterized by an abundance of genetic variation that affects receptor response, but the perceptual effects of this variation are unclear. To address this issue, we sequenced the OR repertoire i…
View article: Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated Open
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here…
View article: Author response: Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
Author response: Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The mouse olfa…
View article: Simplifying the Odor Landscape
Simplifying the Odor Landscape Open
The vast number of detectable odors makes matching olfactory receptors (ORs) to their ligands a daunting task. Krautwurst and colleagues have hypothesized that this process can be simplified by focusing on those odorants that are perceptua…
View article: Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated Open
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000.Thus, the nose is sub-stratified into more than a thousand OSN subtypes.Here, …