Casper Simonsen
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View article: High-intensity resistance training in patients with myositis – 1-year follow-up on a randomised controlled trial
High-intensity resistance training in patients with myositis – 1-year follow-up on a randomised controlled trial Open
Reduced quality of life in patients with myositis is partly due to impairments in muscle strength, muscle endurance and functional capacity. In a recent randomised controlled trial (RCT) (NCT04486261) we showed that high-intensity resistan…
View article: Impact of exercise training on tumour‐infiltrating T cells in human prostate cancer: A secondary analysis of a randomized controlled trial (PRO‐TEST)
Impact of exercise training on tumour‐infiltrating T cells in human prostate cancer: A secondary analysis of a randomized controlled trial (PRO‐TEST) Open
Exercise training reduces tumour growth by increasing tumour‐infiltrating T‐cell density in preclinical models. However, it remains unknown whether exercise training can modify intratumoural T cells in humans.The aim of this study was to c…
View article: Impact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection
Impact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection Open
Sarcopenia defined according to the EWGSOP criteria and with international cut-off points is associated with an increased risk of postoperative complications following pancreatic resection. Using regionally based cut-off points, the preval…
View article: High-intensity resistance training improves quality of life, muscle endurance and strength in patients with myositis: a randomised controlled trial
High-intensity resistance training improves quality of life, muscle endurance and strength in patients with myositis: a randomised controlled trial Open
Myositis is associated with reduced quality of life, which is accompanied by significant impairments in muscle endurance and strength, altogether representing cardinal traits in patients with myositis. This randomised controlled trial aime…
View article: First, do no harm: a call to action to improve the evaluation of harms in clinical exercise research
First, do no harm: a call to action to improve the evaluation of harms in clinical exercise research Open
Exercise as medicine has emerged as an independent discipline in clinical research. Over the last decades, numerous randomised controlled trials (RCTs) have documented the beneficial effects of exercise on various patient-related, disease-…
View article: Quality of life in patients with myositis is associated with functional capacity, body composition, and disease activity—Baseline data from a randomized controlled trial
Quality of life in patients with myositis is associated with functional capacity, body composition, and disease activity—Baseline data from a randomized controlled trial Open
Objective To investigate the potential associations between functional capacity, muscle strength, body composition, and disease‐related measures and quality of life in patients with myositis. Methods Baseline measures of functional capacit…
View article: Postoperative exercise training in patients with colorectal liver metastases undergoing surgery (ELMA): a protocol for a randomized controlled trial
Postoperative exercise training in patients with colorectal liver metastases undergoing surgery (ELMA): a protocol for a randomized controlled trial Open
This is a protocol for a randomized controlled trial.
View article: Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial
Effects of acute exercise training on tumor outcomes in men with localized prostate cancer: A randomized controlled trial Open
Postdiagnosis physical activity is associated with improved cancer outcomes, but biological mechanisms mediating anticancer effects remain unclear. Recent findings suggest that physiological adaptations to acute exercise comprise potential…
View article: The effects of acute exercise and inflammation on immune function in early-stage prostate cancer
The effects of acute exercise and inflammation on immune function in early-stage prostate cancer Open
NCT03675529.
View article: O-198 Fecundity – a marker of health and survival?
O-198 Fecundity – a marker of health and survival? Open
Study question Fecundity (the ability to conceive) may be declining in many high income countries. Does long time to pregnancy reflect a worse of health condition and survival potential in couples? Summary answer We find that time to pregn…
View article: Exercise training to increase tumour natural killer‐cell infiltration in men with localised prostate cancer: a randomised controlled trial
Exercise training to increase tumour natural killer‐cell infiltration in men with localised prostate cancer: a randomised controlled trial Open
Objectives To explore the effects of preoperative high‐intensity interval training (HIIT) compared to usual care on tumour natural killer (NK)‐cell infiltration in men with localised prostate cancer (PCa), as NK‐cell infiltration has been …
View article: Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study
Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study Open
Background Treatment for cancer of the gastro-oesophageal junction (GOJ) can result in considerable and persistent impairment of physical fitness and health-related quality of life (HRQoL). This controlled follow-up study investigated the …
View article: Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial
Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial Open
Context Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial…
View article: Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism
Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism Open
Background: Exercise may improve depression in cancer patients, yet the molecular mechanism behind this protection is poorly understood. Here, we aimed to explore the link between exercise and regulation of kynurenine (Kyn) metabolism and …
View article: Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro-oesophageal junction
Safety and feasibility of preoperative exercise training during neoadjuvant treatment before surgery for adenocarcinoma of the gastro-oesophageal junction Open
Preoperative exercise training during neoadjuvant treatment in patients with GOJ cancer is safe and feasible, with improvements in fitness, strength and quality of life. Preoperative exercise training may be associated with a lower risk of…
View article: PO-378 Exercise-dependent regulation of immune cell function in a clinical cancer perspective
PO-378 Exercise-dependent regulation of immune cell function in a clinical cancer perspective Open
Introduction Exercise is used as supportive therapy for cancer patients, aiming to improve patients’ physical functioning, quality-of-life and cancer-related fatigue. Emerging evidence suggests that exercise may also have direct anti-onco…