Cassandra D. Josephson
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View article: SpO2/FiO2 ratio as a better metric for assessment of RBC transfusion effectiveness in non-traumatic critically ill patients with physiologic derangements
SpO2/FiO2 ratio as a better metric for assessment of RBC transfusion effectiveness in non-traumatic critically ill patients with physiologic derangements Open
Identifying critically ill patients who are likely to improve their respiratory physiology following RBC transfusion is dynamic and difficult. Current decision tools are over-reliant on hemoglobin transfusion thresholds, without considerin…
View article: Hemoglobin Richmond Masquerading as Fetal Hemoglobin in a Child With Sickle Cell Disease: A Case Report and Review of the Literature
Hemoglobin Richmond Masquerading as Fetal Hemoglobin in a Child With Sickle Cell Disease: A Case Report and Review of the Literature Open
View article: Analysis of time to death for children with life‐threatening hemorrhage from traumatic, surgical, and medical etiologies
Analysis of time to death for children with life‐threatening hemorrhage from traumatic, surgical, and medical etiologies Open
Introduction Life‐threatening hemorrhage (LTH) is a significant cause of mortality in pediatrics. Timing of mortality in children with LTH is important for future trials. Methods In a secondary analysis of the prospective observational mas…
View article: Forty‐eight‐hour cold‐stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures
Forty‐eight‐hour cold‐stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures Open
Background and Objectives Cold‐stored whole blood (CS‐WB) in paediatric cardiac surgery is making a resurgence, given its identified benefits compared to conventional blood component therapy (CT). Study Design and Methods A single‐centre r…
View article: Red cell specifications for blood group matching in patients with haemoglobinopathies: An updated systematic review and clinical practice guideline from the International Collaboration for Transfusion Medicine Guidelines
Red cell specifications for blood group matching in patients with haemoglobinopathies: An updated systematic review and clinical practice guideline from the International Collaboration for Transfusion Medicine Guidelines Open
Summary Red blood cell (RBC) antigen matching beyond ABO and RhD is commonly recommended for patients with sickle cell disease (SCD) and thalassaemia. We present an updated systematic literature review to inform evidence‐based guidelines o…
View article: Development and evaluation of trigger tools to identify pediatric blood management errors.
Development and evaluation of trigger tools to identify pediatric blood management errors. Open
It is feasible to automatically detect pediatric PBM errors using existing data captured in the EHR that enable active surveillance systems. Over-transfusions may be one of the most frequent causes of harm in the pediatric environment.
View article: Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates
Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates Open
Importance Red blood cell (RBC) transfusion is a common medical intervention to treat anemia in very preterm neonates; however, best transfusion practices, such as thresholds, remain uncertain. Objective To develop recommendations for clin…
View article: Sex differences in the association of pretransfusion haemoglobin and cognition in preterm infants
Sex differences in the association of pretransfusion haemoglobin and cognition in preterm infants Open
Objectives To assess sex-specific differences in the association between pre-transfusion haemoglobin values and early neurodevelopmental function. Design Observational follow-up of infants with birth weights <1000 g and gestational ages 22…
View article: Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis
Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis Open
Importance Observational studies often report that anemia and red blood cell (RBC) transfusions are associated with a higher risk of necrotizing enterocolitis (NEC) among extremely low-birthweight (ELBW) infants. Objective To evaluate whet…
View article: Survival of transfused red blood cells from a donor with alpha‐thalassemia trait in a recipient with sickle cell disease
Survival of transfused red blood cells from a donor with alpha‐thalassemia trait in a recipient with sickle cell disease Open
Background Post‐transfusion survival of donor red blood cells (RBCs) is important for effective chronic transfusion therapy in conditions including sickle cell disease (SCD). Biotin labeling RBCs allows direct in vivo measurement of multip…
View article: Increased platelet to red blood cell transfusion ratio associated with acute kidney injury in children with life‐threatening bleeding
Increased platelet to red blood cell transfusion ratio associated with acute kidney injury in children with life‐threatening bleeding Open
Introduction Transfusion may increase the risk of organ failure through immunomodulatory effects. The primary objective of this study was to assess for patient or transfusion‐related factors that are independently associated with the risk …
View article: Patient sex and outcomes in children with life‐threatening hemorrhage
Patient sex and outcomes in children with life‐threatening hemorrhage Open
Background Recent data suggest female sex imparts a survival benefit after trauma in adults. The independent associations between patient sex and age with outcomes have not been examined in children with life‐threatening hemorrhage (LTH) f…
View article: Post‐transfusion biotin‐labeled red blood cell survival studies in pediatric sickle cell disease with antibodies of uncertain significance
Post‐transfusion biotin‐labeled red blood cell survival studies in pediatric sickle cell disease with antibodies of uncertain significance Open
Background Red blood cell (RBC) antibodies are common in multiply transfused patients with sickle cell disease (SCD). Unlike RBC alloantibodies, the potential of autoantibodies to cause post‐transfusion hemolysis may be uncertain. Biotin‐l…
View article: Human milk fortification and intestinal inflammation in very preterm infants
Human milk fortification and intestinal inflammation in very preterm infants Open
View article: Association between diet and fecal calprotectin levels in very preterm infants
Association between diet and fecal calprotectin levels in very preterm infants Open
View article: Masthead and Table of Contents
Masthead and Table of Contents Open
View article: Robust Meta-Model for Predicting the Need for Blood Transfusion in Non-traumatic ICU Patients
Robust Meta-Model for Predicting the Need for Blood Transfusion in Non-traumatic ICU Patients Open
Objective: Blood transfusions, crucial in managing anemia and coagulopathy in ICU settings, require accurate prediction for effective resource allocation and patient risk assessment. However, existing clinical decision support systems have…
View article: Robust Meta-Model for Predicting the Likelihood of Receiving Blood Transfusion in Non-traumatic Intensive Care Unit Patients
Robust Meta-Model for Predicting the Likelihood of Receiving Blood Transfusion in Non-traumatic Intensive Care Unit Patients Open
Background: Blood transfusions, crucial in managing anemia and coagulopathy in intensive care unit (ICU) settings, require accurate prediction for effective resource allocation and patient risk assessment. However, existing clinical decisi…
View article: Masthead
Masthead Open
View article: Masthead
Masthead Open
View article: Associations of donor, component, and recipient factors on hemoglobin increments following red blood cell transfusion in very low birth weight infants
Associations of donor, component, and recipient factors on hemoglobin increments following red blood cell transfusion in very low birth weight infants Open
Background Anemia in very low birth weight (VLBW) infants is common and frequently managed with red blood cell (RBC) transfusions. We utilized a linked vein‐to‐vein database to assess the role of blood donors and component factors on measu…
View article: Blood group A enhances SARS-CoV-2 infection
Blood group A enhances SARS-CoV-2 infection Open
Among the risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ABO(H) blood group antigens are among the most recognized predictors of infection. However, the mechanisms by which ABO(H) antigens influence suscepti…
View article: Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression Open
Antibodies against fetal red blood cell (RBC) antigens can cause hemolytic disease of the fetus and newborn (HDFN). Reductions in HDFN due to anti-RhD antibodies have been achieved through use of Rh immune globulin (RhIg), a polyclonal ant…
View article: Masthead and Table of Contents
Masthead and Table of Contents Open
View article: P.096 Effectiveness of palliative focal resective surgery in intracranial EEG confirmed multifocal intractable epilepsy in adult patients
P.096 Effectiveness of palliative focal resective surgery in intracranial EEG confirmed multifocal intractable epilepsy in adult patients Open
Background: Effectiveness of “palliative resections” of a dominant epileptogenic focus in adults with multifocal intractable epilepsy confirmed on intracranial EEG has rarely been reported. Methods: We retrospectively reviewed our database…
View article: Pediatric firearm injury related emergency department visits and hospitalizations: a population-based study in the United States
Pediatric firearm injury related emergency department visits and hospitalizations: a population-based study in the United States Open
View article: Weighing the risk of hemolytic disease of the newborn versus the benefits of using of <scp>RhD</scp>‐positive blood products in trauma
Weighing the risk of hemolytic disease of the newborn versus the benefits of using of <span>RhD</span>‐positive blood products in trauma Open
Hemostatic resuscitation is a blood-based transfusion approach for the treatment of patients with traumatic hemorrhagic shock. Data in both the prehospital and in-hospital settings have demonstrated improved survival with a balanced approa…
View article: Epsilon aminocaproic acid is associated with acute kidney injury after life‐threatening hemorrhage in children
Epsilon aminocaproic acid is associated with acute kidney injury after life‐threatening hemorrhage in children Open
Background Antifibrinolytic medications have been associated with reduced mortality in pediatric hemorrhage but may contribute to adverse events such as acute kidney injury (AKI). Study Design and Methods We conducted a secondary analysis …
View article: Cryoprecipitate for the treatment of life‐threatening hemorrhage in children
Cryoprecipitate for the treatment of life‐threatening hemorrhage in children Open
Background Hypofibrinogenemia is an important risk factor for poor outcomes in children with severe bleeding. There is a paucity of data on the impact of cryoprecipitate transfusion on outcomes in pediatric patients with life‐threatening h…
View article: Proceedings of the 2022 <scp>NHLBI</scp> and <scp>OASH</scp> state of the science in transfusion medicine symposium
Proceedings of the 2022 <span>NHLBI</span> and <span>OASH</span> state of the science in transfusion medicine symposium Open
Background State of the Science (SoS) meetings are used to define and highlight important unanswered scientific questions. The National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, and the Office of the Assistan…