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View article: Somatic mutations in arteriovenous malformations in hereditary hemorrhagic telangiectasia support a bi-allelic two-hit mutation mechanism of pathogenesis
Somatic mutations in arteriovenous malformations in hereditary hemorrhagic telangiectasia support a bi-allelic two-hit mutation mechanism of pathogenesis Open
View article: <i>APOE4</i> alters the lipid droplet proteome and modulates droplet dynamics
<i>APOE4</i> alters the lipid droplet proteome and modulates droplet dynamics Open
Excess lipid droplet (LD) accumulation is associated with several pathological states, including Alzheimer’s disease (AD). However, the mechanism(s) by which changes in LD composition and dynamics contribute to pathophysiology of these dis…
View article: Lipid Droplet Dynamics are Modulated by Age and APOE Genotype
Lipid Droplet Dynamics are Modulated by Age and APOE Genotype Open
Background Aging microglia accumulate lipid droplets (LDs), secrete pro‐inflammatory cytokines, and are defective in phagocytosis. The E4 allele of Apolipoprotein E ( APOE ) is the strongest genetic risk factor for late‐onset Alzheimer’s d…
View article: APOE genotype modifies microglial immunometabolism
APOE genotype modifies microglial immunometabolism Open
Background Metabolic dysfunction and neuroinflammation characterize Alzheimer’s disease (AD), but it is unclear if these two facets of the disease are linked. The E4 allele of Apolipoprotein E (APOE) is the strongest genetic risk factor fo…
View article: Executive summary of the 14th HHT international scientific conference
Executive summary of the 14th HHT international scientific conference Open
View article: APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge Open
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bul…
View article: <i>APOE</i> modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
<i>APOE</i> modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge Open
Summary The E4 allele of Apolipoprotein E ( APOE ) is associated with both metabolic dysfunction and a heightened pro-inflammatory response – two findings that may be intrinsically linked through the concept of immunometabolism. Here, we c…