Catalin M. Filipeanu
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View article: Molecular dissection of the role of ACE2 in glucose homeostasis
Molecular dissection of the role of ACE2 in glucose homeostasis Open
Angiotensin-converting enzyme 2 (ACE2) was discovered 25 years ago as a negative regulator of the renin-angiotensin system, opposing the effects of angiotensin II. Beyond its well-demonstrated roles in cardiovascular regulation and COVID-1…
View article: UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension
UBR1 Promotes Sex-Dependent ACE2 Ubiquitination in Hypertension Open
Background Angiotensin (Ang)-II impairs the function of the antihypertensive enzyme ACE2 by promoting its internalization, ubiquitination and degradation thus contributing to hypertension. However, few ACE2 ubiquitination partners have bee…
View article: Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension
Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension Open
Aims Angiotensin-converting enzyme 2 (ACE2) is a critical component of the compensatory renin–angiotensin system that is down-regulated during the development of hypertension, possibly via ubiquitination. However, little is known about the…
View article: Angiotensin Type 1 Receptor-Dependent Internalization of SARS-CoV-2 by Angiotensin-Converting Enzyme 2
Angiotensin Type 1 Receptor-Dependent Internalization of SARS-CoV-2 by Angiotensin-Converting Enzyme 2 Open
HomeHypertensionVol. 77, No. 4Angiotensin Type 1 Receptor-Dependent Internalization of SARS-CoV-2 by Angiotensin-Converting Enzyme 2 Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citat…
View article: 375. TDP-43 Interacts with Cannabinoid Type 1 Receptor Modulating Its Signaling Properties
375. TDP-43 Interacts with Cannabinoid Type 1 Receptor Modulating Its Signaling Properties Open
To identify new molecular chaperones of cannabinoid type-1 receptors (CB1R), we used a proteomic approach in HEK293T cells, transfected with two spicing variants of this receptor, CB1R and CB1AR. These two isoforms differ only in the compo…