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View article: Multi-omic profiling reveals age-related immune dynamics in healthy adults
Multi-omic profiling reveals age-related immune dynamics in healthy adults Open
The generation and maintenance of immunity is a dynamic process that is dependent on age1-3. Here, to better understand its progression, we profiled peripheral immunity in more than 300 healthy adults (25 to 90 years of age) usi…
View article: Blood samples collected under anesthesia can be used as a source of non-diseased controls for immune-based assays
Blood samples collected under anesthesia can be used as a source of non-diseased controls for immune-based assays Open
Recruiting very young, healthy children to serve as age-matched controls in research presents substantial ethical and practical challenges. One potential approach to address this issue is to recruit healthy children who are referred for el…
View article: Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study
Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study Open
ObjectiveAdults represent over half of incident type 1 diabetes, yet research on disease progression predominantly focuses on at-risk children. We aimed to compare autoantibody screening outcomes and type 1 diabetes progression in adults v…
View article: Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study
Contrasting Adult vs. Pediatric populations in a cohort of at risk relatives: The TrialNet Pathway to Prevention Study Open
ObjectiveAdults represent over half of incident type 1 diabetes, yet research on disease progression predominantly focuses on at-risk children. We aimed to compare autoantibody screening outcomes and type 1 diabetes progression in adults v…
View article: Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects
Novel T Cell reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Subjects Open
Type 1 Diabetes (T1D) is an autoimmune disease mediated by autoreactive T cells. Our studies indicate that CD4 T cells reactive to Hybrid Insulin Peptides (HIPs) play a critical role in T cell-mediated beta-cell destruction. We have shown …
View article: Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis
Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis Open
CONTEXT: COVID-19 has been associated with features of a cytokine storm syndrome with some patients sharing features with the hyperinflammatory disorder, secondary hemophagocytic lymphohistiocytosis (sHLH). HYPOTHESIS: We hypothesized that…
View article: Excessive monitoring for Hydroxychloroquine retinal toxicity in a trial to delay clinical type 1 diabetes created burden without benefit
Excessive monitoring for Hydroxychloroquine retinal toxicity in a trial to delay clinical type 1 diabetes created burden without benefit Open
Background/Aims Type 1 Diabetes TrialNet (TrialNet) conducted a placebo randomized trial in children and adults with pre-clinical type 1 diabetes (T1D) to test whether hydroxychloroquine (HCQ) could delay or prevent progression to clinical…
View article: Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes
Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes Open
The CD2-depleting drug alefacept (LFA3-Ig) preserved beta cell function in new-onset type 1 diabetes (T1D) patients. The most promising biomarkers of response were late expansion of exhausted CD8 T cells and rare baseline inflammatory isle…
View article: ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes
ISPAD Clinical Practice Consensus Guidelines 2024: Screening, Staging, and Strategies to Preserve Beta-Cell Function in Children and Adolescents with Type 1 Diabetes Open
The International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines represent a rich repository that serves as the only comprehensive set of clinical recommendations for children, adolescents, and young adults living with di…
View article: Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes
Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes Open
Disease-causing variants in key immune homeostasis genes can lead to monogenic autoimmune diabetes. Some individuals carrying disease-causing variants do not develop autoimmune diabetes, even though they develop another autoimmune disease.…
View article: Systemic inflammation and lymphocyte activation precede rheumatoid arthritis
Systemic inflammation and lymphocyte activation precede rheumatoid arthritis Open
Some autoimmune diseases, including rheumatoid arthritis (RA), are preceded by a critical subclinical phase of disease activity. Proactive clinical management is hampered by a lack of biological understanding of this subclinical ‘at-risk’ …
View article: Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults
Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults Open
Summary The generation and maintenance of protective immunity is a dynamic interplay between host and environment that is impacted by age. Understanding fundamental changes in the healthy immune system that occur over a lifespan is critica…
View article: Erratum. Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 2024;47:1276–1298
Erratum. Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care 2024;47:1276–1298 Open
View article: Correction to: Consensus guidance for monitoring individuals with islet autoantibody‑positive pre‑stage 3 type 1 diabetes
Correction to: Consensus guidance for monitoring individuals with islet autoantibody‑positive pre‑stage 3 type 1 diabetes Open
View article: Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis
Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis Open
OBJECTIVES We aimed to define and validate novel biomarkers that could identify individuals with COVID-19 associated secondary hemophagocytic lymphohistiocytosis (sHLH) and to test whether fatalities due to COVID-19 in the presence of sHLH…
View article: Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19
Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19 Open
Acute respiratory distress syndrome (ARDS) has a fibroproliferative phase that may be followed by pulmonary fibrosis. Pulmonary fibrosis following COVID-19 pneumonia has been described at autopsy and following lung transplantation. We hypo…
View article: PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in Acute Respiratory Distress Syndrome
PD-L1 and PD-1 Are Associated with Clinical Outcomes and Alveolar Immune Cell Activation in Acute Respiratory Distress Syndrome Open
The relationship between the PD-L1 (Programmed Death-Ligand 1)/PD-1 pathway, lung inflammation, and clinical outcomes in acute respiratory distress syndrome (ARDS) is poorly understood. We sought to determine whether PD-L1/PD-1 in the lung…
View article: Consensus guidance for monitoring persons with islet autoantibody-positive pre-Stage 3 type 1 diabetes
Consensus guidance for monitoring persons with islet autoantibody-positive pre-Stage 3 type 1 diabetes Open
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes (T1D) diagnosis and emerging availability of therapy to delay disease progression, T1D screening programs are be…
View article: Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes Open
View article: Consensus guidance for monitoring persons with islet autoantibody-positive pre-Stage 3 type 1 diabetes
Consensus guidance for monitoring persons with islet autoantibody-positive pre-Stage 3 type 1 diabetes Open
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes (T1D) diagnosis and emerging availability of therapy to delay disease progression, T1D screening programs are be…
View article: Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes
Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes Open
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programs…
View article: Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas
Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas Open
View article: Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency. Open
We previously reported two siblings with inherited PD-1 deficiency who died from autoimmune pneumonitis at 3 and 11 years of age after developing other autoimmune manifestations, including type 1 diabetes (T1D). We report here two siblings…
View article: Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles
Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles Open
Exhausted CD8 T cells (T EX ) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT + KLRG1 + T EX with teplizumab therapy in type 1 diabetes (T1D), in the absence …
View article: Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review Open
View article: Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment Open
View article: Testing a new platform to screen disease-modifying therapy in type 1 diabetes
Testing a new platform to screen disease-modifying therapy in type 1 diabetes Open
Studies of new therapies to preserve insulin secretion in early type 1 diabetes require several years to recruit eligible subjects and to see a treatment effect; thus, there is interest in alternative study designs to speed this process. M…
View article: A standardized metric to enhance clinical trial design and outcome interpretation in type 1 diabetes
A standardized metric to enhance clinical trial design and outcome interpretation in type 1 diabetes Open
The use of a standardized outcome metric enhances clinical trial interpretation and cross-trial comparison. If a disease course is predictable, comparing modeled predictions with outcome data affords the precision and confidence needed to …
View article: Self-reactive germline-like TCR alpha chains shared between blood and pancreas
Self-reactive germline-like TCR alpha chains shared between blood and pancreas Open
Human islet antigen reactive CD4 + memory T cells (IAR T cells) from peripheral blood have been studied extensively for their role in the pathogenesis of autoimmune type 1 diabetes (T1D). However, IAR T cells are rare, and it remains poorl…
View article: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment Open