Allan R. Martin
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View article: Laminoplasty Versus Laminectomy and Fusion in the Treatment of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Cost and Patient-Centered Outcomes in the United States
Laminoplasty Versus Laminectomy and Fusion in the Treatment of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Cost and Patient-Centered Outcomes in the United States Open
Study design Systematic review and meta-analysis. Objective This systematic review and meta-analysis compared cervical laminoplasty (LP) with laminectomy and fusion (LF) for the treatment of degenerative cervical myelopathy (DCM), focusing…
View article: Assessing the diagnostic accuracy of symptoms and signs of degenerative cervical myelopathy: A prospective study
Assessing the diagnostic accuracy of symptoms and signs of degenerative cervical myelopathy: A prospective study Open
Degenerative cervical myelopathy (DCM) is a clinical diagnosis based on history, physical exam, and imaging, but standardized criteria have not been established, contributing to diagnostic delays. We conducted a prospective study of DCM an…
View article: The Cannabinoid Pharmacology of Bone Healing: Developments in Fusion Medicine
The Cannabinoid Pharmacology of Bone Healing: Developments in Fusion Medicine Open
Background/Objectives: Cannabinoid use is rising among patients undergoing spinal fusion, yet its influence on bone healing is poorly defined. The endocannabinoid system (ECS)—through cannabinoid receptors 1 (CB1) and 2 (CB2)—modulates ske…
View article: Assessing Pain and Anxiety Impact in Smokers with Spine Fractures Managed Without Surgery: A Retrospective Cohort Study
Assessing Pain and Anxiety Impact in Smokers with Spine Fractures Managed Without Surgery: A Retrospective Cohort Study Open
Background/Objective: Smoking is known to impair fracture healing and worsen surgical outcomes, but its effect on psychological recovery in spine trauma patients remains unclear. The purpose of this study is to assess how smoking affects p…
View article: Identification and Management of Neurologic Complications in Patients Undergoing Adult Spinal Deformity Surgery
Identification and Management of Neurologic Complications in Patients Undergoing Adult Spinal Deformity Surgery Open
Study Design Narrative Literature Review. Objective To provide a comprehensive literature review of neurologic complications in Adult Spinal Deformity (ASD) surgery in the pre-operative, peri-operative and post-operative periods. Methods A…
View article: Blood Management and Conservation During Adult Spine Deformity Surgery
Blood Management and Conservation During Adult Spine Deformity Surgery Open
Study Design Narrative literature review. Objectives To summarize the evidence for perioperative blood conservation for patients undergoing surgery for adult spine deformity. Methods A systematic literature review with narrative analysis w…
View article: Perioperative Medical Complications in Adult Spine Deformity Surgery: Classification and Prevention Strategies
Perioperative Medical Complications in Adult Spine Deformity Surgery: Classification and Prevention Strategies Open
Study Design Narrative review. Objective We aimed to propose the classifications of, risk factors for, and prevention strategies for perioperative complications from previously published papers in adult spinal deformity (ASD) surgeries. Me…
View article: Monitoring morphometric drift in lifelong learning segmentation of the spinal cord.
Monitoring morphometric drift in lifelong learning segmentation of the spinal cord. Open
Morphometric measures derived from spinal cord segmentations can serve as diagnostic and prognostic biomarkers in neurological diseases and injuries affecting the spinal cord. For instance, the spinal cord cross-sectional area can be used …
View article: A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement
A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement Open
Study Design Systematic review. Objectives The pre-symptomatic state of Degenerative Cervical Myelopathy (DCM), wherein degenerative changes and spinal cord compression are seen without clinical findings, is poorly understood and inconsist…
View article: AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy
AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy Open
Study Design Literature review of key topics related to degenerative cervical myelopathy (DCM) with critical appraisal and clinical recommendations. Objective This article summarizes several key current topics related to the management of …
View article: Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: Evolutionary origins of spinal cord tumors: A cross-species systematic review
Evolutionary origins of spinal cord tumors: A cross-species systematic review Open
Objective Intradural spinal cord tumors, particularly intramedullary glial neoplasms such as astrocytomas, ependymomas, and oligodendrogliomas, are rare in humans but pose significant diagnostic and therapeutic challenges. Despite their cl…
View article: Validation of a Precise Impactor in a Rodent Cervical Spinal Cord Injury Hemi-Contusion Model
Validation of a Precise Impactor in a Rodent Cervical Spinal Cord Injury Hemi-Contusion Model Open
Background: Cervical spinal cord injuries (SCIs) are the most common type of human SCI. Although various animal SCI contusion models have been developed to mirror human pathology, few have described cervical-level injuries. This study aims…
View article: Systematic Review of Peptide CAQK: Properties, Applications, and Outcomes
Systematic Review of Peptide CAQK: Properties, Applications, and Outcomes Open
Many central nervous system (CNS) disorders lack approved treatment options. Previous research demonstrated that peptide CAQK can bind to chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix of the CNS. In vivo studies hav…
View article: A minimum data set—Core outcome set, core data elements, and core measurement set—For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study
A minimum data set—Core outcome set, core data elements, and core measurement set—For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study Open
Background Degenerative cervical myelopathy (DCM) is a progressive chronic spinal cord injury estimated to affect 1 in 50 adults. Without standardised guidance, clinical research studies have selected outcomes at their discretion, often un…
View article: Diffusion Tensor Imaging in Diagnosing and Evaluating Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis
Diffusion Tensor Imaging in Diagnosing and Evaluating Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis Open
Study Design Systematic review. Objective Degenerative cervical myelopathy (DCM) is a common spinal cord disorder necessitating surgery. We aim to explore how effectively diffusion tensor imaging (DTI) can distinguish DCM from healthy indi…
View article: Validity of a Smartphone App to Objectively Monitor Performance Outcomes in Degenerative Cervical Myelopathy: Preliminary Findings From a Longitudinal Observational Study
Validity of a Smartphone App to Objectively Monitor Performance Outcomes in Degenerative Cervical Myelopathy: Preliminary Findings From a Longitudinal Observational Study Open
Background Developing new clinical measures for degenerative cervical myelopathy (DCM) is an AO Spine RECODE-DCM research priority. Difficulties detecting DCM, and changes in DCM, cause diagnostic and treatment delays in clinical settings …
View article: Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management
A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management Open
Study Design Clinical practice guideline development following the GRADE process. Objectives Hemodynamic management is one of the only available treatment options that likely improves neurologic outcomes in patients with acute traumatic sp…
View article: Interventions to Optimize Spinal Cord Perfusion in Patients With Acute Traumatic Spinal Cord Injury: An Updated Systematic Review
Interventions to Optimize Spinal Cord Perfusion in Patients With Acute Traumatic Spinal Cord Injury: An Updated Systematic Review Open
Study design Systematic review update. Objectives Interventions that aim to optimize spinal cord perfusion are thought to play an important role in minimizing secondary ischemic damage and improving outcomes in patients with acute traumati…
View article: A Clinical Practice Guideline for Prevention, Diagnosis and Management of Intraoperative Spinal Cord Injury: Recommendations for Use of Intraoperative Neuromonitoring and for the Use of Preoperative and Intraoperative Protocols for Patients Undergoing Spine Surgery
A Clinical Practice Guideline for Prevention, Diagnosis and Management of Intraoperative Spinal Cord Injury: Recommendations for Use of Intraoperative Neuromonitoring and for the Use of Preoperative and Intraoperative Protocols for Patients Undergoing Spine Surgery Open
Study Design Development of a clinical practice guideline following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process. Objective The objectives of this study were to develop guidelines that outline the …
View article: An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery
An Update of a Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Role and Timing of Decompressive Surgery Open
Study Design Clinical practice guideline development. Objectives Acute spinal cord injury (SCI) can result in devastating motor, sensory, and autonomic impairment; loss of independence; and reduced quality of life. Preclinical evidence sug…
View article: The Management of Intraoperative Spinal Cord Injury – A Scoping Review
The Management of Intraoperative Spinal Cord Injury – A Scoping Review Open
Study Design Scoping Review. Objective To review the literature and summarize information on checklists and algorithms for responding to intraoperative neuromonitoring (IONM) alerts and management of intraoperative spinal cord injuries (IS…
View article: Timing of Decompressive Surgery in Patients With Acute Spinal Cord Injury: Systematic Review Update
Timing of Decompressive Surgery in Patients With Acute Spinal Cord Injury: Systematic Review Update Open
Study design Systematic review and meta-analysis. Objective Surgical decompression is a cornerstone in the management of patients with traumatic spinal cord injury (SCI); however, the influence of the timing of surgery on neurological reco…
View article: Correlation Between Pre-Operative Diffusion Tensor Imaging Indices and Post-Operative Outcome in Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis
Correlation Between Pre-Operative Diffusion Tensor Imaging Indices and Post-Operative Outcome in Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis Open
Study Design Systematic review. Objectives The correlation between pre-operative diffusion tensor imaging (DTI) metrics and post-operative clinical outcomes in patients with degenerative cervical myelopathy (DCM) has been widely investigat…
View article: Degenerative Thoracic Myelopathy: A Scoping Review of Epidemiology, Genetics, and Pathogenesis
Degenerative Thoracic Myelopathy: A Scoping Review of Epidemiology, Genetics, and Pathogenesis Open
Study Design Literature Review. Objective Myelopathy affecting the thoracic spinal cord can arise secondary to several aetiologies which have similar presentation and management. Consequently, there are many uncertainties in this area, inc…
View article: Management of mild degenerative cervical myelopathy and asymptomatic spinal cord compression: an international survey
Management of mild degenerative cervical myelopathy and asymptomatic spinal cord compression: an international survey Open
Study design Cross-sectional survey. Objective Currently there is limited evidence and guidance on the management of mild degenerative cervical myelopathy (DCM) and asymptomatic spinal cord compression (ASCC). Anecdotal evidence suggest va…
View article: The Frequency of Symptoms in Patients With a Diagnosis of Degenerative Cervical Myelopathy: Results of a Scoping Review
The Frequency of Symptoms in Patients With a Diagnosis of Degenerative Cervical Myelopathy: Results of a Scoping Review Open
Study Design Delayed diagnosis of degenerative cervical myelopathy (DCM) is associated with reduced quality of life and greater disability. Developing diagnostic criteria for DCM has been identified as a top research priority. Objectives T…