Caterina Minelli
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View article: Synchrotron-Based Structural Analysis of Nanosized Gd2(Ti1−xZrx)2O7 for Radioactive Waste Management
Synchrotron-Based Structural Analysis of Nanosized Gd2(Ti1−xZrx)2O7 for Radioactive Waste Management Open
Complex oxides with the general formula Gd2(Ti1−xZrx)2O7 are promising candidates for radioactive waste immobilization due to their capacity to withstand radiation by dissipating part of the free energy driving defect creation and phase tr…
View article: Best practice for the size analysis of nanomedicines – An iron sucrose case study
Best practice for the size analysis of nanomedicines – An iron sucrose case study Open
Iron sucrose is used in the parenteral treatment of iron deficiency anaemia. A number of iron sucrose similars have been developed alongside the original product. These products consist of colloidal iron with particles in the nanometre ran…
View article: Non-invasive quantitative chemical measurements of liposomal formulations using Raman spectroscopy
Non-invasive quantitative chemical measurements of liposomal formulations using Raman spectroscopy Open
Raman spectroscopy methods for quantitative chemical measurements of nanomedicines, applied to liposomal doxorubicin through the wall of a glass vial.
View article: Toward an international standardisation roadmap for nanomedicine
Toward an international standardisation roadmap for nanomedicine Open
The French National Metrology Institute (LNE) initiated a series of events to identify priorities for test methods and their harmonisation that directly address regulatory needs in Nanomedicine. One of these workshops entitled “The Interna…
View article: Standards and Metrology for Viral Vectors as Molecular Tools: Outcomes from a CCQM Workshop
Standards and Metrology for Viral Vectors as Molecular Tools: Outcomes from a CCQM Workshop Open
Viral vectors are agents enabling gene transfer and genome editing and have widespread utility across the healthcare and biotechnology sectors. In January 2023, the International Bureau for Weights and Measures’ Consultative Committee for …
View article: Advanced Chemical and Imaging Methods for Studying Structure Morphology and Excipients Solid State Transformations in Pharmaceutical Multiparticulate Formulations
Advanced Chemical and Imaging Methods for Studying Structure Morphology and Excipients Solid State Transformations in Pharmaceutical Multiparticulate Formulations Open
The formulation of paediatric medicines faces significant challenges to meet the requirements for safe and accurate administration, while maintaining a suitable taste. Multiparticulate formulations have a strong potential to address these …
View article: Nanoparticle Isolation from Biological Media for Protein Corona Analysis: The Impact of Incubation and Recovery Protocols on Nanoparticle Properties
Nanoparticle Isolation from Biological Media for Protein Corona Analysis: The Impact of Incubation and Recovery Protocols on Nanoparticle Properties Open
Nanoparticles are increasingly implemented in biomedical applications, including the diagnosis and treatment of disease. When exposed to complex biological media, nanoparticles spontaneously interact with their surrounding environment, lea…
View article: Nanoparticle isolation from biological media for protein corona analysis: The impact of incubation and recovery protocols on nanoparticle attributes
Nanoparticle isolation from biological media for protein corona analysis: The impact of incubation and recovery protocols on nanoparticle attributes Open
The use of nanoparticles has increasingly been implemented in biomedical applications including the diagnosis and treatment of disease. When administered to a biological system, nanoparticles spontaneously interact with their surrounding e…
View article: Evaluating the impact of experimental shear flow parameters on nanoparticle protein corona formation
Evaluating the impact of experimental shear flow parameters on nanoparticle protein corona formation Open
The use of nanoparticles has increasingly been implemented in biomedical applications including the diagnosis and treatment of disease. When administered to a biological system, nanoparticles spontaneously interact with their surrounding e…
View article: Combining orthogonal measurements to unveil diclofenac encapsulation into polymeric and lipid nanocarriers
Combining orthogonal measurements to unveil diclofenac encapsulation into polymeric and lipid nanocarriers Open
The quantification of the drug associated to nanoparticle carriers, often expressed in terms of encapsulation efficiency, is a regulatory requirement. The establishment of independent methods to evaluate this parameter provides a means for…
View article: Knowledge, attitude and practice of pharmacovigilance among Nepalese health professionals
Knowledge, attitude and practice of pharmacovigilance among Nepalese health professionals Open
Introduction: Although Nepal joined the WHO program for International Drug Monitoring in 2006, published data about Nepalese health professionals’ understanding of pharmacovigilance and spontaneous reporting of adverse drug reactions (ADRs…
View article: Deagglomeration of DNA nanomedicine carriers using controlled ultrasonication
Deagglomeration of DNA nanomedicine carriers using controlled ultrasonication Open
Control over the agglomeration state of manufactured particle systems for drug and oligonucleotide intracellular delivery is paramount to ensure reproducible and scalable therapeutic efficacy. Ultrasonication is a well-established mechanis…
View article: Investigating the Impact of Shear Flow on Nanoparticle-Protein Interactions
Investigating the Impact of Shear Flow on Nanoparticle-Protein Interactions Open
Most nanoparticle-based therapies are intended for intravenous administration, exposing them to associated hemodynamic parameters and the presence of cells and biomacromolecules post-administration. While most efforts in nanomedicine devel…
View article: Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles
Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles Open
This study compared results of nanoparticle number concentration measurements collected from 74 instruments hosted across 50 laboratories, providing users with useful discussion and reference data to assess and benchmark their measurement …
View article: Measurement of the Size Distribution of Multimodal Colloidal Systems by Laser Diffraction
Measurement of the Size Distribution of Multimodal Colloidal Systems by Laser Diffraction Open
Laser diffraction (LD) is a well-established tool for the measurement of particle size distribution. Recently, its demand and use for the measurement of complex biological systems have increased. Among the challenges that these types of sa…
View article: Formulation and Characterization of Phytostanol Ester Solid Lipid Nanoparticles for the Management of Hypercholesterolemia: An ex vivo Study
Formulation and Characterization of Phytostanol Ester Solid Lipid Nanoparticles for the Management of Hypercholesterolemia: An ex vivo Study Open
Phytostanol ester solid lipid nanoparticles were successfully formulated and characterized. The formulation has the potential to provide an innovative drug delivery system for phytostanols which reduce cholesterol and have a potentially id…
View article: Nanoparticle number concentration measurements by multi-angle dynamic light scattering
Nanoparticle number concentration measurements by multi-angle dynamic light scattering Open
We present the use of Multi-angle Dynamic Light Scattering (MADLS®) for the measurement of nanoparticle concentration. We describe the theory of the method and its application to nanoparticles made of gold, silica and polystyrene, with dia…
View article: Emerging Standards and Analytical Science for Nanoenabled Medical Products
Emerging Standards and Analytical Science for Nanoenabled Medical Products Open
Development and application of nanotechnology-enabled medical products, including drugs, devices, and in vitro diagnostics, are rapidly expanding in the global marketplace. In this review, the focus is on providing the reader with an intro…
View article: Correction: Schavkan, A., et al. Number Concentration of Gold Nanoparticles in Suspension: SAXS and spICPMS as Traceable Methods Compared to Laboratory Methods. Nanomaterials 2019, 9, 502
Correction: Schavkan, A., et al. Number Concentration of Gold Nanoparticles in Suspension: SAXS and spICPMS as Traceable Methods Compared to Laboratory Methods. Nanomaterials 2019, 9, 502 Open
The authors wish to make the following corrections to this paper [...]
View article: Number Concentration of Gold Nanoparticles in Suspension: SAXS and spICPMS as Traceable Methods Compared to Laboratory Methods
Number Concentration of Gold Nanoparticles in Suspension: SAXS and spICPMS as Traceable Methods Compared to Laboratory Methods Open
The industrial exploitation of high value nanoparticles is in need of robust measurement methods to increase the control over product manufacturing and to implement quality assurance. InNanoPart, a European metrology project responded to t…
View article: Establishing SI-Traceability of Nanoparticle Size Values Measured with Line-Start Incremental Centrifugal Liquid Sedimentation
Establishing SI-Traceability of Nanoparticle Size Values Measured with Line-Start Incremental Centrifugal Liquid Sedimentation Open
Line-start incremental centrifugal liquid sedimentation (disc-CLS) is a powerful technique to determine particle size based on the principles of Stokes’ law. As most input quantities of the Stokes equation cannot be easily determined for t…
View article: A perspective on nanomedicine: focus on cardiovascular medicine
A perspective on nanomedicine: focus on cardiovascular medicine Open
Background:
\nNanomedicine refers to the application of nanotechnology to improve the diagnosis, monitoring and treatment of diseases. Although the primary application was originally in oncology, nanomedicine has witnessed substantial scie…
View article: Robust and accurate measurements of gold nanoparticle concentrations using UV-visible spectrophotometry
Robust and accurate measurements of gold nanoparticle concentrations using UV-visible spectrophotometry Open
This paper provides an empirical formula to calculate the extinction efficiencies of gold nanoparticles over the size range 1–1000 nm in fluids with refractive indexes which extend from n = 1 to n = 1.62. The formula contains a shape facto…
View article: Cover Image, Volume 50, Issue 9
Cover Image, Volume 50, Issue 9 Open
The cover image, by Donald R. Baer et al., is based on the Rapid Communication Importance of sample preparation on reliable surface characterisation of nano-objects: ISO standard 20579-4, https://doi.org/10.1002/sia.6523. Design credit: Al…
View article: Measuring the relative concentration of particle populations using differential centrifugal sedimentation
Measuring the relative concentration of particle populations using differential centrifugal sedimentation Open
The factors that affect the accuracy and precision of differential centrifugal sedimentation (DCS) for the analysis of nanoparticle concentration are described.
View article: Measuring the size and density of nanoparticles by centrifugal sedimentation and flotation
Measuring the size and density of nanoparticles by centrifugal sedimentation and flotation Open
Analytical centrifugation in sedimentation and flotation modes is used to measure both the size and density of polystyrene nanoparticles.
View article: Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization Open
The sonication process is commonly used for de-agglomerating and dispersing nanomaterials in aqueous based media, necessary to improve homogeneity and stability of the suspension. In this study, a systematic step-wise approach is carried o…
View article: Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization Open
The sonication process is commonly used for de-agglomerating and dispersing nanomaterials in aqueous based media, necessary to improve homogeneity and stability of the suspension. In this study, a systematic step-wise approach is carried o…
View article: Peptide engineered microcantilevers for selective chemical force microscopy and monitoring of nanoparticle capture
Peptide engineered microcantilevers for selective chemical force microscopy and monitoring of nanoparticle capture Open
Engineered peptides capable of binding to silica have been used to provide contrast in chemical force microscopy and tested for their capacity to selectively capture silica nanoparticles (NPs). Gold coated atomic force microscopy (AFM) mic…
View article: Versailles Project on Advanced Materials and Standards Interlaboratory Study on Measuring the Thickness and Chemistry of Nanoparticle Coatings Using XPS and LEIS
Versailles Project on Advanced Materials and Standards Interlaboratory Study on Measuring the Thickness and Chemistry of Nanoparticle Coatings Using XPS and LEIS Open
We report the results of a VAMAS (Versailles Project on Advanced Materials and Standards) inter-laboratory study on the measurement of the shell thickness and chemistry of nanoparticle coatings. Peptide-coated gold particles were supplied …