Explanipedia

Beyond systemic lupus erythematosus: a systematic review on the use of belimumab in other connective tissue diseases and vasculitides Open

F. Santoro, Martina Orlandi, Caterina Vacchi · 2025

Introduction Belimumab is a monoclonal antibody with proven efficacy in systemic lupus erythematosus. However, its role in other connective tissue diseases or vasculitides is still not clear. Methods A systematic literature review (SLR) of…

Real-World Use of Anifrolumab for Articular Involvement in Systemic Lupus Erythematosus: A Monocentric Case Series and Systematic Review Open

Giulia Cassone, F. Santoro, Mariagrazia Nuara, Chiara Cabassi, Caterina Vacchi , et al. · 2025

Introduction: This study evaluates the real-world application of anifrolumab in managing articular involvement in systemic lupus erythematosus (SLE), providing insights into its efficacy and safety in routine clinical practice. Additionall…

POS0826 PREVALENCE, INCIDENCE AND SURVIVAL IN INTERSTITIAL LUNG DISEASE SECONDARY TO PRIMARY SJOGREN'S SYNDROME. RESULTS FROM THE “EMERGE” LONGITUDINAL STUDY Open

Andreina Manfredi, Caterina Vacchi, Stefania Cerri, Roberta Eufrasia Ledda, Giulia Cassone , et al. · 2025

Prevalence of Progressive Fibrosing Interstitial Lung Disease in Patients with Primary Sjogren Syndrome Open

Andreina Manfredi, Gianluca Sambataro, Alessandra Rai, Stefania Cerri, Domenico Sambataro , et al. · 2024

Background: Interstitial lung disease (ILD) represents a frequent cause of morbidity and mortality in primary Sjogren syndrome (pSS). However, the prevalence and behavior of pSS-ILD remains incomplete, largely based on retrospective hetero…

Sjögren's Syndrome and Pulmonary Hypertension: Exploring the Intricate Link with Interstitial Lung Disease Open

Francesca Coppi, Gianluca Pagnoni, C. Campani, Francesca Grossule, Caterina Vacchi , et al. · 2024

Fibrosing Progressive Interstitial Lung Disease in Rheumatoid Arthritis: A Multicentre Italian Study Open

Marco Sebastiani, Vincenzo Venerito, Elenia Laurino, Stefano Gentileschi, Fabiola Atzeni , et al. · 2023

Background: The INBUILD study demonstrated the efficacy of nintedanib in the treatment of progressive fibrosing interstitial lung disease different to idiopathic pulmonary fibrosis, including rheumatoid arthritis (RA)-related ILD. Neverthe…

POS1053 PREVALENCE OF FIBROSING PROGRESSIVE INTERSTITIAL LUNG DISEASE IN RHEUMATOID ARTHRITIS PATIENTS Open

Andreina Manfredi, Vincenzo Venerito, Massimiliano Cazzato, Stefano Gentileschi, Laura La Corte , et al. · 2023

Classification of pulmonary sounds through deep learning for the diagnosis of interstitial lung diseases secondary to connective tissue diseases Open

Behnood Dianat, Paolo La Torraca, Andreina Manfredi, Giulia Cassone, Caterina Vacchi , et al. · 2023

Molecular Pathways of Breast Cancer in Systemic Sclerosis: Exploratory Immunohistochemical Analysis from the Sclero-Breast Study Open

Chrystel Isca, Amelia Spinella, Angela Toss, Marco de Pinto, Guido Ficarra , et al. · 2022

Several authors reported an increased risk of cancer in SSc patients, including breast cancer (BC). Nevertheless, the mechanisms underlying this association have not yet been clarified. SSc and BC share several molecular pathways, which se…

Personalized Medicine and Machine Learning: A Roadmap for the Future Open

Marco Sebastiani, Caterina Vacchi, Andreina Manfredi, Giulia Cassone · 2022

In the last ten years, many advances have been made in the treatment and diagnosis of immune-mediated diseases [...]

C-reactive protein and 10-year cardiovascular risk in rheumatoid arthritis Open

Gian Luca Erre, Fabio Cacciapaglia, Garifallia Sakellariou, Andreina Manfredi, Elena Bartoloni , et al. · 2022

Pneumopathie interstitielle fibrosante dans le syndrome de Gougerot-Sjögren primitif Open

Andreina Manfredi, Caterina Vacchi, Giovanni Della Casa, Stefania Cerri, Giulia Cassone , et al. · 2022

COVID-19 vaccination rate and safety profile in a multicentre Italian population affected by mixed cryoglobulinaemic vasculitis Open

Caterina Vacchi, Sofia Testoni, Marcella Visentini, Roberta Zani, Gianfranco Lauletta , et al. · 2022

Vaccination against SARS-CoV-2 has been performed in a high percentage of MCV patients with encouraging safety profile. Vasculitis flares rate was in line with that observed for other autoimmune diseases, despite patients with purpura or p…

Diagnosis, Clinical Features and Management of Interstitial Lung Diseases in Rheumatic Disorders: Still a Long Journey Open

Marco Sebastiani, Caterina Vacchi, Giulia Cassone, Andreina Manfredi · 2022

Interstitial lung disease (ILD) is one of the most frequent pulmonary complications of autoimmune rheumatic diseases (ARDs), and it is mainly associated with connective tissue diseases (CTDs) and rheumatoid arthritis (RA) [...]

VECTOR: An algorithm for the detection of COVID-19 pneumonia from velcro-like lung sounds Open

Fabrizio Pancaldi, Giuseppe Pezzuto, Giulia Cassone, Marianna Morelli, Andreina Manfredi , et al. · 2022

Estimated 10-year cardiovascular risk in a large Italian cohort of rheumatoid arthritis patients: Data from the Cardiovascular Obesity and Rheumatic DISease (CORDIS) Study Group Open

Fabio Cacciapaglia, Francesca Romana Spinelli, Matteo Piga, Gian Luca Erre, Garifallia Sakellariou , et al. · 2021

Clinical and Pathological Features of Breast Cancer in Systemic Sclerosis: Results from the Sclero-Breast Study Open

Angela Toss, Amelia Spinella, Chrystel Isca, Caterina Vacchi, Guido Ficarra , et al. · 2021

Systemic Sclerosis (SSc) is a chronic disease associated with a 1.5-fold increase in cancer risk, including lung cancer, hematological malignancies, and breast cancer (BC). This is a retrospective study aiming to explore the clinical and p…

Fibrosing interstitial lung disease in primary Sjogren syndrome Open

Andreina Manfredi, Caterina Vacchi, G. Della Casa, Stefania Cerri, Giulia Cassone , et al. · 2021

AB0425 CLINICAL AND PATHOLOGICAL FEATURES OF BREAST CANCER IN PATIENTS WITH SYSTEMIC SCLEROSIS: PRELIMINARY DATA FROM THE SCLERO-BREAST STUDY Open

Amelia Spinella, Angela Toss, Chrystel Isca, Caterina Vacchi, Anna Iannone , et al. · 2021

Tofacitinib for the Treatment of Severe Interstitial Lung Disease Related to Rheumatoid Arthritis Open

Caterina Vacchi, Andreina Manfredi, Giulia Cassone, Stefania Cerri, Giovanni Della Casa , et al. · 2021

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by chronic symmetrical erosive synovitis and extra-articular manifestations, including interstitial lung disease (ILD), whose treatment is nowadays challeng…

Efficacy and safety of rituximab in the treatment of connective tissue disease-related interstitial lung disease Open

Caterina Vacchi, Andreina Manfredi, Giulia Cassone, Gian Luca Erre, Carlo Salvarani , et al. · 2021

Interstitial lung disease (ILD) represents a severe pulmonary complication of connective tissue diseases, rheumatoid arthritis (RA), and antineutrophil cytoplasmic antibody-associated vasculitis. Treatment of ILD, mainly based on immunosup…

Efficacy and safety of mycophenolate mofetil in the treatment of rheumatic disease-related interstitial lung disease: a narrative review Open

Giulia Cassone, Marco Sebastiani, Caterina Vacchi, Gian Luca Erre, Carlo Salvarani , et al. · 2021

Mycophenolate mofetil (MMF) is an antimetabolite with a potent inhibitory effect on proliferation of T and B lymphocytes used since the early 1990s for the prevention of acute allograft rejection after organ transplant. MMF is also widely …

Interstitial Pneumonia with Autoimmune Features: Why Rheumatologist-Pulmonologist Collaboration Is Essential Open

Marco Sebastiani, Paola Faverio, Andreina Manfredi, Giulia Cassone, Caterina Vacchi , et al. · 2020

In 2015 the European Respiratory Society (ERS) and the American Thoracic Society (ATS) “Task Force on Undifferentiated Forms of Connective Tissue Disease-associated Interstitial Lung Disease” proposed classification criteria for a new rese…

Erratum to acute exacerbation of interstitial lung diseases secondary to systemic rheumatic diseases: a prospective study and review of the literature Open

Andreina Manfredi, Marco Sebastiani, Stefania Cerri, Caterina Vacchi, Roberto Tonelli , et al. · 2020

In the article that appeared on Page 1621-1628, Vol 11, No 4 (April 2019) Issue of the Journal of Thoracic Disease (1), the given and family names of author “Fabrizio Pancaldi” was incorrectly published in the original. The author's name s…

COVID-19-associated vasculitis and thrombotic complications: from pathological findings to multidisciplinary discussion Open

Caterina Vacchi, Marianna Meschiari, Jovana Milić, Marco Marietta, Roberto Tonelli , et al. · 2020

Neutrophilic arterial vasculitis in COVID-19 represents a novel finding and could be responsible for thrombotic complications.

Pathogenesis and treatment of idiopathic and rheumatoid arthritis-related interstitial pneumonia. The possible lesson from COVID-19 pneumonia Open

Andreina Manfredi, Fabrizio Luppi, Giulia Cassone, Caterina Vacchi, Carlo Salvarani , et al. · 2020

Introduction: Main clinical manifestations of SARS-CoV-2 infection are characterized by fever, dyspnea, and interstitial pneumonia, frequently evolving in acute respiratory distress syndrome (ARDS). Areas covered: Features of coronavirus d…

Usefulness of digital velcro crackles detection in identification of interstitial lung disease in patients with connective tissue diseases Open

Andreina Manfredi, Giulia Cassone, Caterina Vacchi, Fabrizio Pancaldi, Giovanni Della Casa , et al. · 2020

Objectives: This study aims to evaluate the diagnostic accuracy of the VECTOR software in patients with connective tissue diseases (CTDs), compared with the reference standard of high-resolution computed tomography (HRCT). Patients and met…

Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar) Open

Caterina Vacchi, Marcella Visentini, Laura Gragnani, Paolo Fraticelli, Antonio Tavoni , et al. · 2020

AB0426 FIBROSING INTERSTITIAL LUNG DISEASE IN PRIMARY SJOGREN SYNDROME Open

Andreina Manfredi, Caterina Vacchi, Giovanni Della Casa, Stefania Cerri, Giovanna Di Cecco , et al. · 2020

AB0528 CHARACTERIZATION OF ANTI-MPO POSITIVE INTERSTITIAL LUNG DISEASE. CLINICAL-SEROLOGIC AND RADIOLOGIC FEATURES AND SURVIVAL Open

Giulia Cassone, Giulia Dei, Gianluca Sambataro, Andreina Manfredi, Stefania Cerri , et al. · 2020

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