Catherine A. Chappell
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View article: A randomized trial of double vs single-dose etonogestrel implant to overcome the interaction with efavirenz-based antiretroviral therapy
A randomized trial of double vs single-dose etonogestrel implant to overcome the interaction with efavirenz-based antiretroviral therapy Open
Over 48 weeks of combined use, placing 2 etonogestrel implants suppressed ovulation and increased plasma etonogestrel exposure when compared with 1 etonogestrel implant among women on efavirenz-based antiretroviral therapy. Doubling the do…
View article: Population Pharmacokinetics of Sofosbuvir/Velpatasvir in Pregnant Women with Hepatitis C Virus
Population Pharmacokinetics of Sofosbuvir/Velpatasvir in Pregnant Women with Hepatitis C Virus Open
View article: 1102. Pediatric Hepatitis C Screening by Maternal Hepatitis C Viral Load Status in Pregnancy
1102. Pediatric Hepatitis C Screening by Maternal Hepatitis C Viral Load Status in Pregnancy Open
Background The rise of hepatitis C (HCV) infections among reproductive-age women increases the number of infants at risk for perinatal HCV infection, but screening remains low. It is unknown if maternal HCV viral load (VL) during pregnancy…
View article: DELIVER: A Safety Study of a Dapivirine Vaginal Ring and Oral PrEP for the Prevention of HIV During Pregnancy
DELIVER: A Safety Study of a Dapivirine Vaginal Ring and Oral PrEP for the Prevention of HIV During Pregnancy Open
Background: Pregnancy represents a period of high HIV acquisition risk. Safety data for the monthly dapivirine vaginal ring (DVR) during pregnancy are limited. Here, we report data from the first 2 cohorts of pregnant participants in MTN-0…
View article: Effect of double-dose levonorgestrel subdermal implant in women taking efavirenz-based antiretroviral therapy: The DoubLNG pharmacokinetic study
Effect of double-dose levonorgestrel subdermal implant in women taking efavirenz-based antiretroviral therapy: The DoubLNG pharmacokinetic study Open
View article: Evidence for Implementation: HIV/HCV Coinfection and Pregnancy
Evidence for Implementation: HIV/HCV Coinfection and Pregnancy Open
View article: Pharmacokinetics of levonorgestrel and etonogestrel contraceptive implants over 48 weeks with rilpivirine- or darunavir-based antiretroviral therapy
Pharmacokinetics of levonorgestrel and etonogestrel contraceptive implants over 48 weeks with rilpivirine- or darunavir-based antiretroviral therapy Open
Background Pharmacokinetic data are lacking for progestin-releasing subdermal contraceptive implants when used with either rilpivirine- or darunavir/ritonavir-based ART. Objectives To characterize the pharmacokinetics of etonogestrel or le…
View article: Postpartum Follow-up Care for Pregnant Persons With Opioid Use Disorder and Hepatitis C Virus Infection
Postpartum Follow-up Care for Pregnant Persons With Opioid Use Disorder and Hepatitis C Virus Infection Open
Among Medicaid-enrolled pregnant persons with opioid use disorder, one third are diagnosed with hepatitis C virus, but only 6% receive postpartum follow-up or medication treatment.
View article: Motives and risk perceptions of participants in a phase 1 trial for Hepatitis C Virus investigational therapy in pregnancy
Motives and risk perceptions of participants in a phase 1 trial for Hepatitis C Virus investigational therapy in pregnancy Open
Limited research has been done among pregnant people participating in investigational drug trials. To enhance the ethical understanding of pregnant people’s perspectives on research participation, we sought to describe motives and risk per…
View article: 115 Screening and infection rates for hepatitis C virus (HCV) in pregnancy with opiate use disorder
115 Screening and infection rates for hepatitis C virus (HCV) in pregnancy with opiate use disorder Open
View article: Experiences and Perspectives From Women Taking Investigational Therapy for Hepatitis C Virus During Pregnancy
Experiences and Perspectives From Women Taking Investigational Therapy for Hepatitis C Virus During Pregnancy Open
Objective: Describe the experiences and perspectives among pregnant people with chronic HCV infection receiving ledipasvir/sofosbuvir (LDV/SOF) therapy during pregnancy. Methods: We conducted semi-structured, in-depth interviews within an …
View article: Ledipasvir plus sofosbuvir in pregnant women with hepatitis C virus infection: a phase 1 pharmacokinetic study
Ledipasvir plus sofosbuvir in pregnant women with hepatitis C virus infection: a phase 1 pharmacokinetic study Open
View article: Elevated Risk of Bacterial Vaginosis Among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study
Elevated Risk of Bacterial Vaginosis Among Users of the Copper Intrauterine Device: A Prospective Longitudinal Cohort Study Open
Background Limited evidence suggests that the nonhormonal contraceptive copper intrauterine device (Cu-IUD) may increase bacterial vaginosis (BV) risk, possibly due to increased volume and duration of menses, a common side effect of Cu-IUD…
View article: Hepatitis C Virus in Pregnancy: Are We Ready for Test and Treat?
Hepatitis C Virus in Pregnancy: Are We Ready for Test and Treat? Open
One of the most significant consequences of the opioid epidemic is the increased prevalence of hepatitis C virus (HCV) among pregnant women, which carries the risk of perinatal transmission.This increased prevalence of HCV in pregnant wome…
View article: A Phase One Pharmacokinetic Study of Ledipasvir/Sofosbuvir in Pregnant Women with Hepatitis C Virus
A Phase One Pharmacokinetic Study of Ledipasvir/Sofosbuvir in Pregnant Women with Hepatitis C Virus Open
View article: Drug interactions: not just for orally administered drugs
Drug interactions: not just for orally administered drugs Open
View article: Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART
Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART Open
Background We previously demonstrated that etonogestrel concentrations were 82% lower in women using etonogestrel contraceptive implants plus efavirenz-based ART compared with women not receiving ART. Objectives To investigate the genetic …
View article: Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study
Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study Open
View article: Testing for Hepatitis C in Pregnancy: the Time Has Come for Routine Rather than Risk-Based
Testing for Hepatitis C in Pregnancy: the Time Has Come for Routine Rather than Risk-Based Open
View article: Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa
Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa Open
The findings support task shifting of IUD insertion to mid-level providers to improve IUD access in Sub-Saharan Africa.
View article: Hepatitis C Virus Screening Among Children Exposed During Pregnancy
Hepatitis C Virus Screening Among Children Exposed During Pregnancy Open
OBJECTIVES: Because of the opioid epidemic, hepatitis C virus (HCV) infection is increasing among pregnant women, resulting in an increased risk of perinatal transmission and HCV infection among children. Our primary objectives in this stu…
View article: Heterogeneity of HIV-1 Replication in Ectocervical and Vaginal Tissue<i>Ex Vivo</i>
Heterogeneity of HIV-1 Replication in Ectocervical and Vaginal Tissue<i>Ex Vivo</i> Open
In clinical trials evaluating HIV-1 prevention products, ex vivo exposure of mucosal tissue to HIV-1 is performed to inform drug levels needed to suppress viral infection. Understanding assay and participant variables that influence HIV-1 …
View article: Use of an endotracheal tube for surgical abortion complicated by a leiomyomatous uterus: a case report
Use of an endotracheal tube for surgical abortion complicated by a leiomyomatous uterus: a case report Open
With distorted or markedly enlarged uterine anatomy rendering pregnancy tissue inaccessible with routine surgical instruments, the minimally invasive use of an endotracheal tube may aid completion of uterine evacuation for surgical uterine…
View article: Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception
Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception Open
Objective: To evaluate the potential for a clinically relevant drug–drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contrac…
View article: Drug–Drug Interactions, Effectiveness, and Safety of Hormonal Contraceptives in Women Living with HIV
Drug–Drug Interactions, Effectiveness, and Safety of Hormonal Contraceptives in Women Living with HIV Open
View article: The Effects of Hormones and Vaginal Microflora on the Glycome of the Female Genital Tract: Cervical-Vaginal Fluid
The Effects of Hormones and Vaginal Microflora on the Glycome of the Female Genital Tract: Cervical-Vaginal Fluid Open
In this study, we characterized the glycome of cervical-vaginal fluid, collected with a Catamenial cup. We quantified: glycosidase levels; sialic acid and high mannose specific lectin binding; mucins, MUC1, MUC4, MUC5AC, MUC7; and albumin …
View article: Impact of Bacterial Vaginosis, as Assessed by Nugent Criteria and Hormonal Status on Glycosidases and Lectin Binding in Cervicovaginal Lavage Samples
Impact of Bacterial Vaginosis, as Assessed by Nugent Criteria and Hormonal Status on Glycosidases and Lectin Binding in Cervicovaginal Lavage Samples Open
The objective of this study was to evaluate the impact of hormonal status and bacterial vaginosis (BV) on the glycosidases present and glycosylation changes as assessed by lectin binding to cervicovaginal lavage constituents. Frozen cervic…
View article: Studying the Effects of Reproductive Hormones and Bacterial Vaginosis on the Glycome of Lavage Samples from the Cervicovaginal Cavity
Studying the Effects of Reproductive Hormones and Bacterial Vaginosis on the Glycome of Lavage Samples from the Cervicovaginal Cavity Open
The cervicovaginal fluid (CVF) coating the vaginal epithelium is an important immunological mediator, providing a barrier to infection. Glycosylation of CVF proteins, such as mucins, IgG and S-IgA, plays a critical role in their immunologi…
View article: The effect of menopause on the innate antiviral activity of cervicovaginal lavage
The effect of menopause on the innate antiviral activity of cervicovaginal lavage Open