Explanipedia

Chronic conditions and risk of severe outcomes among adults aged 18-59 years with medically-attended RSV illness in the United States Open

Daniel K. Nomah, Linwei Li, Z. John Shen, Neloufar Rahai, Meng Wang , et al. · 2025

Background Respiratory Syncytial Virus (RSV) can cause severe respiratory disease. While risks among older adults are well established, less is known about RSV severity in younger adults with chronic conditions. Methods A retrospective coh…

P-1189. Clinical Characteristics and Outcomes of Medically Attended Respiratory Syncytial Virus (RSV) Infections in Children 24-59 months of Age Open

Zhe Zheng, Jennifer P. King, Linwei Li, Tianyu Sun, Catherine A. Panozzo , et al. · 2025

Background RSV infection is a major cause of lower respiratory tract disease (LRTD) among young children. However, clinical features of RSV disease in children ≥24 months of age are not well described. This study assessed the signs, sympto…

Clinical Characteristics of Virologically Confirmed Respiratory Syncytial Virus in English Primary Care: Protocol for an Observational Study of Acute Respiratory Infection Open

Uy Hoang, Utkarsh Agrawal, José M Ordóñez-Mena, Zachary A. Marcum, Jennifer M. Radin , et al. · 2024

Background There are gaps in our understanding of the clinical characteristics and disease burden of the respiratory syncytial virus (RSV) among community-dwelling adults. This is in part due to a lack of routine testing at the point of ca…

Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults Open

Catherine A. Panozzo, Edward E. Walsh, Zhèn Yáng, Eleanor Wilson, Jaya Goswami , et al. · 2024

Economic burden of cardiorespiratory hospitalizations associated with respiratory syncytial virus among United States adults in 2017–2019 Open

Deesha Patel, Zachary A. Marcum, Aisara Chansakul, Astra Toyip, Katherine Nerney , et al. · 2024

Morbidity and mortality caused by respiratory syncytial virus (RSV) in older adults and those with underlying health conditions can be potentially alleviated through vaccination. To assist vaccine policy decision-makers and payers, we esti…

Incidence of RSV in Adults: A Comprehensive Review of Observational Studies and Critical Gaps in Information Open

Benjamin Doty, Parinaz Ghaswalla, Rhonda L. Bohn, Sonia Stoszek, Catherine A. Panozzo · 2024

Background We conducted a global comprehensive literature review of observational studies reporting respiratory syncytial virus (RSV) incidence in adults and determined current evidence gaps. Methods PubMed and Embase were searched for Eng…

Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults Open

Catherine A. Panozzo, Edward E. Walsh, Zhèn Yáng, Eleanor Wilson, Jaya Goswami , et al. · 2024

This study analyzed previously published data in hospital and community cohorts of adults with respiratory syncytial virus (RSV)–associated symptoms. Shortness of breath (dyspnea) alone, and in combination with certain other lower respirat…

Safety and Immunogenicity of an mRNA-Based RSV Vaccine Including a 12-Month Booster in a Phase 1 Clinical Trial in Healthy Older Adults Open

Christine A. Shaw, Brandon Essink, Charles Harper, Runa Mithani, Archana Kapoor , et al. · 2024

Background An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults. Methods Based on a randomized, observer-blind, placebo-controlled design, this ph…

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults Open

Eleanor Wilson, Jaya Goswami, Abdullah H Baqui, Pablo Alexis Doreski, Gonzalo Perez-Marc , et al. · 2023

A single dose of the mRNA-1345 vaccine resulted in no evident safety concerns and led to a lower incidence of RSV-associated lower respiratory tract disease and of RSV-associated acute respiratory disease than placebo among adults 60 years…

The Annual Economic Burden of Respiratory Syncytial Virus in Adults in the United States Open

Justin Carrico, Katherine A. Hicks, Eleanor Wilson, Catherine A. Panozzo, Parinaz Ghaswalla · 2023

Background Current estimates of the economic burden of respiratory syncytial virus (RSV) are needed for policymakers to evaluate adult RSV vaccination strategies. Methods A cost-of-illness model was developed to estimate the annual societa…

903. Prevalence of Underlying Conditions Associated With Higher Risk for Severe RSV, Influenza, or COVID-19 in Adults in the United States, 2017-2018 Open

Parinaz Ghaswalla, Abigail Hitchens, Sean D. Candrilli, Justin Carrico, Katherine A. Hicks , et al. · 2023

Background Respiratory syncytial virus (RSV), influenza, and COVID-19 pose a significant health risk to older adults and individuals with certain underlying health conditions. The descriptive epidemiology of such conditions can guide effor…

Economic burden of respiratory syncytial virus infection in adults: a systematic literature review Open

Mei Grace, Ann Colosia, Sorrel Wolowacz, Catherine A. Panozzo, Parinaz Ghaswalla · 2023

Despite several data gaps, the economic burden of RSV infections on healthcare systems and payers was found to be substantial, globally, underscoring the need for RSV preventive strategies for reducing this burden.

234. Safety and Immunogenicity of mRNA-1345, an mRNA-Based RSV Vaccine in Younger and Older Adult Cohorts: Results from a Phase 1, Randomized Clinical Trial Open

Grace Chen, Runa Mithani, Archana Kapoor, Sophia Lu, Laila El Asmar , et al. · 2022

Background Respiratory syncytial virus (RSV) is a public health burden; no vaccine is currently available. An mRNA-based RSV vaccine (mRNA-1345) encoding the RSV prefusion stabilized F (preF) glycoprotein is under clinical investigation. M…

116. Potential Clinical Impact of Respiratory Syncytial Virus (RSV) Vaccination in Older Adults in the United States Open

Kelly Fust, Michele Kohli, Catherine A. Panozzo, Milton C. Weinstein, Philip O. Buck , et al. · 2022

Background RSV causes acute respiratory disease (ARD), including severe lower respiratory tract disease (LRTD) in older adults, which can lead to hospitalization and death. Currently, there are no vaccines approved to prevent RSV disease. …

Why Do They Wait? Characterizing Mothers with High HPV Vaccine Intent Yet Unvaccinated Adolescents Open

Tuhina Srivastava, Katharine J. Head, Sean M. O’Dell, Kristen A. Feemster, Catherine A. Panozzo , et al. · 2022

Efficacy of tailored messages to improve behavioral intent to accept HPV vaccination among mothers may be moderated by sociodemographics Open

Kristen A. Feemster, Katharine J. Head, Catherine A. Panozzo, Sean M. O’Dell, Gregory D. Zimet , et al. · 2021

BBCIC Research Network Analysis of First-Cycle Prophylactic G-CSF Use in Patients Treated With High–Neutropenia Risk Chemotherapy Open

Pamala A. Pawloski, Cara L. McDermott, James Marshall, Vanita K. Pindolia, Catherine M. Lockhart , et al. · 2021

Background: Chemotherapy-induced febrile neutropenia (FN) is prevented or minimized with granulocyte colony-stimulating factors (G-CSFs). Several G-CSF biosimilars are approved in the United States. The Biologics and Biosimilars Collective…

Health outcomes coding trends in the <span>US</span> Food and Drug Administration's Sentinel System during transition to International Classification of Diseases‐10 coding system: A brief review Open

Young Hee Nam, Aaron B. Mendelsohn, Catherine A. Panozzo, Judith C. Maro, Jeffrey S. Brown · 2021

Background and purpose The transition from International Classification of Diseases, 9th revision, clinical modification (ICD‐9‐CM) to ICD‐10‐CM poses a challenge to epidemiologic studies that use diagnostic codes to identify health outcom…

Vaccine Safety Datalink infrastructure enhancements for evaluating the safety of maternal vaccination Open

Allison L. Naleway, Bradley Crane, Stephanie A. Irving, Don Bachman, Kimberly K. Vesco , et al. · 2021

Background: Identifying pregnancy episodes and accurately estimating their beginning and end dates are imperative for observational maternal vaccine safety studies using electronic health record (EHR) data. Methods: We modified the Vaccine…

Developing algorithms for identifying major structural birth defects using automated electronic health data Open

Elyse O. Kharbanda, Gabriela Vazquez‐Benitez, Malini B. DeSilva, Alicen B. Spaulding, Matthew F. Daley , et al. · 2020

Purpose Given the 2015 transition to International Classification of Diseases , Tenth Revision , Clinical Modification ( ICD‐10‐CM ) diagnostic coding, updates to our previously published algorithms for major structural birth defects (BDs)…

Erratum. Use of Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Type 1 Diabetes and Rates of Diabetic Ketoacidosis. Diabetes Care 2020;43:90–97 Open

Christian Hampp, Richard S. Swain, Casie Horgan, Elizabeth Dee, Yandong Qiang , et al. · 2020

To comply with a new (January 2020) legal interpretation of the Data Use Agreement between the U.S. Food and Drug Administration’s Sentinel Initiative and the Centers for Medicare & Medicaid Services, the authors have made changes to the p…

Demographic and Clinical Characteristics of COPD Medication Users in the Sentinel Distributed Database Open

Y. Li, Elnara Fazio‐Eynullayeva, Marie C. Bradley, J. Chen, S. Chin , et al. · 2020

Geographic Variation in Pneumonia and Influenza in Long-Term Care Facilities: A National Study Open

Elliott Bosco, Andrew R. Zullo, Kevin W. McConeghy, Patience Moyo, Robertus van Aalst , et al. · 2020

Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018 Open

Catherine A. Panozzo, Lesley H. Curtis, James Marshall, Lawrence J. Fine, Barbara L. Wells , et al. · 2019

Incidence of statin use varied by CVD and DM comorbidity, and was lowest among those without CVD. These results highlight the potential clinical equipoise to conduct large pragmatic clinical trials to generate evidence that could be used t…

Descriptive Analysis of Long- and Intermediate-Acting Insulin and Key Safety Outcomes in Adults with Type 2 Diabetes Mellitus Open

Daniel J. Kent, Cheryl N. McMahill‐Walraven, Catherine A. Panozzo, Pamala A. Pawloski, Kevin Haynes , et al. · 2019

This study was coordinated and funded by the Biologics and Biosimilars Collective Intelligence Consortium (BBCIC) and represents the independent findings of the BBCIC Insulins Principal Investigator and the BBCIC Insulins Research Team. Lo…

Harnessing the Biologics and Biosimilars Collective Intelligence Consortium to Evaluate Patterns of Care Open

Cheryl N. McMahill‐Walraven, Daniel J. Kent, Catherine A. Panozzo, Pamala A. Pawloski, Kevin Haynes , et al. · 2019

This study was coordinated and funded by the Biologics and Biosimilars Collective Intelligence Consortium (BBCIC) and represents the independent findings of the BBCIC Insulins Principal Investigator and the BBCIC Insulins Research Team. Lo…

Associations between HPV vaccination among women and their 11–14-year-old children Open

Melanie L. Kornides, Katharine J. Head, Kristen A. Feemster, Gregory D. Zimet, Catherine A. Panozzo · 2019

The human papillomavirus (HPV) vaccine has been available in the United States for over a decade. We sought to examine the associations between self-reported receipt of HPV vaccination among women and their 11-14-year-old children in 27 lo…

Variation in rotavirus vaccination coding in state US Medicaid data Open

J. Bradley Layton, Anne M. Butler, M. Alan Brookhart, Catherine A. Panozzo · 2019

Provider-level rates of HEDIS-consistent HPV vaccination in a regional health plan Open

Catherine A. Panozzo, Melissa B. Gilkey, Melanie L. Kornides, J. Frank Wharam · 2019

Background. Health insurers are well-positioned to address low HPV vaccination coverage in the US through initiatives such as provider assessment and feedback. However, little is known about the feasibility of using administrative c…

Sentinel Modular Program for Propensity Score–Matched Cohort Analyses Open

Meijia Zhou, Shirley Wang, Charles E. Leonard, Joshua J. Gagne, Candace C. Fuller , et al. · 2017

Sentinel is a program sponsored by the US Food and Drug Administration to monitor the safety of medical products. We conducted a cohort assessment to evaluate the ability of the Sentinel Propensity Score Matching Tool to reproduce in an ex…

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