Catherine Brenner
YOU?
Author Swipe
View article: Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy
Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy Open
Oncogenic metabolism depends on multifaceted mechanisms, including bidirectional inter-organelle communication between mitochondria and the nucleus, facilitating cellular adaptation at the transcriptomic, proteomic, and metabolomic levels.…
View article: The first-in-class pro-apoptotic peptide PEP-010 is effective in monotherapy and in combination with paclitaxel on resistant ovarian adenocarcinoma cell models
The first-in-class pro-apoptotic peptide PEP-010 is effective in monotherapy and in combination with paclitaxel on resistant ovarian adenocarcinoma cell models Open
Ovarian adenocarcinoma is the gynecological malignancy with the worst prognosis and the highest mortality rate. In the first stages of treatment, chemotherapy results effective, but its prolonged use and high doses lead to the appearance o…
View article: A retrospective validation of the effective and safe treatment of patients on general care wards with high velocity nasal insufflation therapy utilizing prognostic risk scores during COVID-19
A retrospective validation of the effective and safe treatment of patients on general care wards with high velocity nasal insufflation therapy utilizing prognostic risk scores during COVID-19 Open
Background Non-invasive positive pressure ventilation (NIPPV) has been a traditional therapy for acute respiratory failure (ARF). However, the use of NIPPV during the COVID-19 pandemic was challenging, while the use of invasive mechanical …
View article: Data from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
Data from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2 Open
Mitochondrial membrane permeabilization (MMP) is a rate-limiting step of apoptosis, including in anticancer chemotherapy. Adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP on the inner mitochondrial membrane in heal…
View article: Supplementary Figures S1 & S2 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
Supplementary Figures S1 & S2 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2 Open
Supplementary Figures S1 & S2 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
View article: Supplementary Table S1 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
Supplementary Table S1 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2 Open
Supplementary Table S1 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
View article: Data from Cisplatin Resistance Associated with PARP Hyperactivation
Data from Cisplatin Resistance Associated with PARP Hyperactivation Open
Non–small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CD…
View article: Supplementary Table S1 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
Supplementary Table S1 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2 Open
Supplementary Table S1 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
View article: Supplementary Table 1, Figures 1 - 8 from Cisplatin Resistance Associated with PARP Hyperactivation
Supplementary Table 1, Figures 1 - 8 from Cisplatin Resistance Associated with PARP Hyperactivation Open
PDF file - 490K, Supplementary Table S1. Systematic comparison of the effects of CDDP and PARP inhibitors on cancer cell lines used in this study. Supplementary Figure S1. Generation and characterization of CDDP-resistant human NSCLC cell …
View article: Supplementary Figures S1 & S2 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
Supplementary Figures S1 & S2 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2 Open
Supplementary Figures S1 & S2 from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
View article: Data from Cisplatin Resistance Associated with PARP Hyperactivation
Data from Cisplatin Resistance Associated with PARP Hyperactivation Open
Non–small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CD…
View article: Supplementary Table 1, Figures 1 - 8 from Cisplatin Resistance Associated with PARP Hyperactivation
Supplementary Table 1, Figures 1 - 8 from Cisplatin Resistance Associated with PARP Hyperactivation Open
PDF file - 490K, Supplementary Table S1. Systematic comparison of the effects of CDDP and PARP inhibitors on cancer cell lines used in this study. Supplementary Figure S1. Generation and characterization of CDDP-resistant human NSCLC cell …
View article: Data from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2
Data from Chemosensitization by Knockdown of Adenine Nucleotide Translocase-2 Open
Mitochondrial membrane permeabilization (MMP) is a rate-limiting step of apoptosis, including in anticancer chemotherapy. Adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP on the inner mitochondrial membrane in heal…
View article: Plasma galectins and metabolites in advanced head and neck carcinomas: evidence of distinct immune characteristics linked to hypopharyngeal tumors
Plasma galectins and metabolites in advanced head and neck carcinomas: evidence of distinct immune characteristics linked to hypopharyngeal tumors Open
Extra-cellular galectins 1, 3 and 9 (gal-1, -3 and -9) are known to act as soluble immunosuppressive agents in various malignancies. Previous publications have suggested that their expression is dependent on the metabolic status of produci…
View article: Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation
Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation Open
Human TRIAP1 (TP53-regulated inhibitor of apoptosis 1; also known as p53CSV for p53-inducible cell survival factor) is the homolog of yeast Mdm35, a well-known chaperone that interacts with the Ups/PRELI family proteins and participates in…
View article: Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma
Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma Open
Osteosarcoma (OS) is a pediatric malignant bone tumor that predominantly affects adolescent and young adults. It has high risk for relapse and over the last four decades no improvement of prognosis was achieved. It is therefore crucial to …
View article: Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network
Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network Open
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. …
View article: Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma
Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a type of liver cancer with a poor prognosis for survival given the complications it bears on the patient. Though damages to the liver are acknowledged prodromic factors, the precise molecular aetiology re…
View article: Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming
Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming Open
Improvement of anticancer treatments is associated with increased survival of cancer patients at risk of cardiac disease. Therefore, there is an urgent need for new therapeutic molecules capable of preventing acute and long-term cardiotoxi…
View article: Profiling the Energy Metabolism at the Cell Subpopulation Level
Profiling the Energy Metabolism at the Cell Subpopulation Level Open
Although being a complex pathology with genetic as well as non-genetic etiologies, cancer is characterized by a limited series of hallmarks including energetic metabolism reprogramming.Long ago O. Warburg unraveled a bias of tumor metaboli…
View article: Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC
Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC Open
Metabolic flexibility is the ability of a cell to adapt its metabolism to changes in its surrounding environment. Such adaptability, combined with apoptosis resistance provides cancer cells with a survival advantage. Mitochondrial voltage-…
View article: Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes Open
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms constitutes a formidable challenge for fundame…
View article: Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats
Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats Open
Berries are rich sources of (poly)phenols which have been associated with the prevention of cardiovascular diseases in animal models and in human clinical trials. Recently, a berry enriched diet was reported to decrease blood pressure and …
View article: AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway
AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway Open
In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival, and proliferation. In all analysed species, it was re…