Explanipedia

Depression in pregnancy: A multinational prospective cohort study Open

Alexandra Roddy Mitchell, Fadia Thamir Ahmed, Catherine Cluver, Richard Hiscock, Anthea Lindquist , et al. · 2025

Within our study cohort, spanning two centres in Pakistan and South Africa, one in six women experienced depression in pregnancy. Reassuringly, depression was not associated with an increase in adverse pregnancy outcomes; spontaneous prete…

Sertraline use in pregnancy and placental transfer: A pharmacokinetic prospective cohort study Open

Charlotte S. Goutallier, Stephen Tong, Cassius M. Phogole, Tracy Kellermann, Manarangi De Silva , et al. · 2025

Introduction Depression in pregnancy is common and the use of antidepressants in pregnancy, especially sertraline, is on the rise. Although sertraline is known to cross the placenta, the level of transfer to the foetus is unclear. Thus, we…

The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts Open

Tu’uhevaha J. Kaitu’u‐Lino, Teresa M. MacDonald, Emerson Keenan, Roxanne Hastie, Catherine Cluver , et al. · 2025

National Health and Medical Research Council (#1065854) and the Norman Beischer Medical Research Foundation. Additional sources of funding for the biobank from South Africa was received from the Swedish Medical Society, Märta Lundqvist Fou…

Clinical diagnostic model for cerebral infarcts in women with eclampsia; a cross-sectional study Open

Lina Bergman, Henrik Imberg, Eduard Langenegger, Allegra Moodley, Richard Pitcher , et al. · 2025

Reduced circulating NrCAM as a biomarker for fetal growth restriction Open

Lucy A. Bartho, Susan P. Walker, Danica Idzes, Alexander Heazell, Lucy Higgins , et al. · 2025

Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia Open

Valentina Bucher, Owen Herrock, Sonja Schell, J. de Visser, Henrik Imberg , et al. · 2025

Prophylactic Aspirin Dose and Preeclampsia Open

Ellen Kupka, Susanne Hesselman, Jóhanna Gunnarsdóttir, Anna‐Karin Wikström, Catherine Cluver , et al. · 2025

Importance It is unclear whether a higher dose (150-160 mg) or a lower dose (75 mg) of aspirin should be used to prevent preeclampsia. Objectives To compare the risk of preeclampsia and bleeding complications between women using 150 to 160…

Tranexamic acid for preventing postpartum haemorrhage after vaginal birth Open

Christa Rohwer, Anke Rohwer, Catherine Cluver, Katharine Ker, G Justus Hofmeyr · 2025

Protocol (2009) DOI: 10.1002/14651858.CD007872 Original review (2010) DOI: 10.1002/14651858.CD007872.pub2 Review update (2015) DOI: 10.1002/14651858.CD007872.pub3.

Associations between Pre-Eclampsia and Sick Leave Following Childbirth: A Swedish Register-Based Cohort Study Open

Therese Friis, Anna Karin Wikström, Susanne Hesselman, Linda Lindström, Katja Junus , et al. · 2025

Circulating concentrations of pro-inflammatory cytokines in preeclampsia with varying disease severity Open

Klara Palm, Catherine Cluver, Eduard Langenegger, Stephen Tong, Susan P. Walker , et al. · 2024

Plasma concentrations of IL-6 and VCAM-1, but not CRP, were increased among women with preeclampsia and end-organ complications, compared with women without end-organ complications. IL-6 and VCAM-1 could be drivers of disease in preeclamps…

Tranexamic acid for preventing postpartum haemorrhage after caesarean section Open

Christa Rohwer, Anke Rohwer, Catherine Cluver, Katharine Ker, G Justus Hofmeyr · 2024

The published protocol and updates to the review can be accessed: Protocol (2009) DOI: 10.1002/14651858.CD007872 Original Review (2010) DOI: 10.1002/14651858.CD007872.pub2 Review Update (2015) DOI: 10.1002/14651858.CD007872.pub3.

Cerebral infarcts, edema, hypoperfusion, and vasospasm in preeclampsia and eclampsia Open

Lina Bergman, Daniel Hannsberger, Sonja Schell, Henrik Imberg, Eduard Langenegger , et al. · 2024

Eclampsia was associated with cerebral infarcts, vasogenic cerebral edema, vasospasm, and decreased perfusion, which are not usually evident on standard clinical imaging. This finding may explain why some patients have cerebral symptoms an…

Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis Open

Hannah Gordon, Noor Salim, Stephen Tong, Susan P. Walker, Manarangi De Silva , et al. · 2024

Prediction of adverse maternal and perinatal outcomes associated with pre-eclampsia and hypertensive disorders of pregnancy: a systematic review and meta-analysis Open

Valentina Bucher, Alexandra Roddy Mitchell, Pia Gudmundsson, Jessica Atkinson, Nicole Wallin , et al. · 2024

Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial Open

Catherine Cluver, Lina Bergman, Henrik Imberg, Ben W. Mol, David Hall , et al. · 2024

Introduction Preterm pre-eclampsia is a leading cause of maternal morbidity and mortality. The Pre-eclampsia Intervention 2 (PI 2) trial suggested that metformin sustained release (XR) may prolong gestation by a week in pregnant women unde…

Metformin in pregnancy and childhood neurodevelopmental outcomes: a systematic review and meta-analysis Open

Hannah Gordon, Jessica Atkinson, Stephen Tong, Parinaz Mehdipour, Catherine Cluver , et al. · 2024

In utero exposure to metformin does not seem to be associated with adverse neurodevelopmental outcomes in children up to the age of 14 years. These findings provide reassurance to clinicians and pregnant women considering metformin use dur…

Trisomy 21 screening with αlpha software and the Fetal Medicine Foundation algorithm Open

L. R. Pistorius, Catherine Cluver, Ismail Bhorat, L. Geerts · 2023

Background. Screening for trisomy 21 provides pregnant women with accurate risk information. Different algorithms are used to screen for trisomy 21 in South Africa (SA). The Fetal Medicine Foundation (FMF) provides software to screen for t…

An LC-MS/MS method for the simultaneous quantitation of sulfasalazine and sulfapyridine in human placenta Open

Vanessa Louw, Fiona Brownfoot, Catherine Cluver, Eric Decloedt, Tracy Kellermann · 2023

Sulfasalazine has been identified as a candidate molecule to be investigated as an intervention to treat preterm pre-eclampsia during pregnancy. However, placental exposure of sulfasalazine and its systemically absorbed metabolite, sulfapy…

Circulating concentrations of pro-inflammatory cytokines in preeclampsia with varying disease severity Open

Klara Palm, Catherine Cluver, Eduard Langenegger, Stephen Tong, Susan P. Walker , et al. · 2023

Background Preeclampsia affects about 5% of pregnancies and is diagnosed by new onset of hypertension with end-organ dysfunction. It is hypothesized that systemic inflammation causes maternal vascular endothelial dysfunction and vascular i…

Impact of fetal growth restriction on pregnancy outcome in women undergoing expectant management for preterm pre‐eclampsia Open

Catherine Cluver, Lina Bergman, Johanna Bergkvist, Henrik Imberg, L. Geerts , et al. · 2023

Objectives To assess whether coexisting fetal growth restriction (FGR) influences pregnancy latency among women with preterm pre‐eclampsia undergoing expectant management. Secondary outcomes assessed were indication for delivery, mode of d…

Prevalence of Perinatal Depression in Low- and Middle-Income Countries Open

Alexandra Roddy Mitchell, Hannah Gordon, Anthea Lindquist, Susan P. Walker, Caroline Homer , et al. · 2023

Importance Women who experience depression during or within a year of pregnancy are at increased risk of morbidity and mortality. Although those living in low- and middle-income countries are thought to be at increased risk of perinatal de…

Circulating Chemerin Is Elevated in Women With Preeclampsia Open

Lucy A. Bartho, Manju Kandel, Susan P. Walker, Catherine Cluver, Roxanne Hastie , et al. · 2023

Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential of circulating chemerin to predict preecla…

The need for appropriate language in the debate on medicalisation of pregnancy Open

Catherine Cluver, Christianne J.M. de Groot, Ben W. Mol, Kellie E. Murphy, Jane E. Norman , et al. · 2023

Editorial: Preeclampsia and the brain: Pre-clinical and clinical studies of cerebral involvement in preeclampsia Open

Lina Bergman, Carlos Escudero, Catherine Cluver, Roxanne Hastie, Pablo Torres‐Vergara · 2023

EDITORIAL article Front. Physiol., 15 February 2023Sec. Clinical and Translational Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1151091

An Lc-Ms/Ms Method for the Simultaneous Quantitation of Sulfasalazine and Sulfapyridine in Human Placenta Open

Vanessa Louw, Fiona Brownfoot, Catherine Cluver, Tracy Kellermann · 2023

Correlation between cognitive assessment scores and circulating cerebral biomarkers in women with pre-eclampsia and eclampsia Open

Emma Bokström-Rees, Henrik Zetterberg, Kaj Blennow, Roxanne Hastie, Sonja Schell , et al. · 2022

Circulating concentrations of glycocalyx degradation products in preeclampsia Open

Niclas Carlberg, Catherine Cluver, Camilla Hesse, Sven‐Egron Thörn, Robin E. Gandley , et al. · 2022

Background and Objectives: Preeclampsia is a multisystem disorder that affects maternal endothelium. The glycocalyx lines and protects the endothelial surface. In severe systemic diseases, like sepsis, it is shed and glycocalyx degradation…

Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia Open

Roxanne Hastie, Lina Bergman, Susan P. Walker, Tu’uhevaha J. Kaitu’u‐Lino, Natalie J. Hannan , et al. · 2022

Background The angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are postulated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels should become more deranged …

Population pharmacokinetics of esomeprazole in patients with preterm preeclampsia Open

Manna Semere Gebreyesus, Eric Decloedt, Catherine Cluver, Nicole Hunfeld, Hólmfríður Helgadóttir , et al. · 2022

Esomeprazole is a proton pump inhibitor being investigated for treatment of preeclampsia. Esomeprazole pharmacokinetics during pregnancy are unknown. We used data from 10 pregnant participants with preterm preeclampsia, and 49 non‐pregnant…

Low-Dose Aspirin for Preventing Birth of a Small-For-Gestational Age Neonate in a Subsequent Pregnancy Open

Roxanne Hastie, Stephen Tong, Anna‐Karin Wikström, Susan P. Walker, Anthea Lindquist , et al. · 2022

OBJECTIVE: To estimate whether low-dose aspirin use is associated with an altered risk of delivering a small-for-gestational age (SGA) neonate among women with a history of having an SGA neonate in a prior pregnancy. METHODS: We performed …

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