Alfredo Costa
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View article: International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative
International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative Open
This is the first focused endeavor to favor the implementation of socio-cognitive assessment, which is required by DSM-5 but seldom performed despite clear evidence of its clinical relevance for diagnosis and care. Our results provide an i…
View article: Fluid biomarkers across the Alzheimer's disease continuum: assessing their relationship with the patients’ clinical variant and profile
Fluid biomarkers across the Alzheimer's disease continuum: assessing their relationship with the patients’ clinical variant and profile Open
Background Alzheimer's disease (AD) molecular hallmarks are the accumulation of β‐amyloid (Aβ) peptides and phosphorylated tau proteins in the patients’ cerebral cortex. For this reason, the measurement of cerebrospinal fluid (CSF) levels …
View article: HomeCoRe for telerehabilitation in mild or major neurocognitive disorders: a non-inferiority randomized controlled trial
HomeCoRe for telerehabilitation in mild or major neurocognitive disorders: a non-inferiority randomized controlled trial Open
This randomized controlled trial (RCT) assessed the non-inferiority of HomeCoRe, a home-based version of the CoRe (Cognitive Rehabilitation) software, compared to its in-clinic counterpart in older adults with mild or major neurocognitive …
View article: Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes
Cerebrospinal Fluid Biomarkers Profiling in Cerebral Amyloid Angiopathy and Relationship With Disease Phenotypes Open
Background Cerebral amyloid angiopathy (CAA) is a heterogeneous small vessel disease that can occur independently or alongside Alzheimer disease (AD). CAA is diagnosed using the Boston Criteria 2.0, integrating clinical and neuroimaging fe…
View article: Essential Amino Acid Supplementation May Attenuate Systemic Inflammation and Improve Hypoalbuminemia in Subacute Hemiplegic Stroke Patients
Essential Amino Acid Supplementation May Attenuate Systemic Inflammation and Improve Hypoalbuminemia in Subacute Hemiplegic Stroke Patients Open
Background: Post-stroke inflammation and hypoalbuminemia can negatively affect neurocognitive recovery. This study evaluated whether oral amino acid (AA) supplementation with prevalently essential amino acids (EAAs, 82.1%) could improve in…
View article: Alterations in topological and dynamical parameters correlate with disease biomarkers and neuropsychological scores in prodromic stages of dementia
Alterations in topological and dynamical parameters correlate with disease biomarkers and neuropsychological scores in prodromic stages of dementia Open
BACKGROUND Mild cognitive impairment (MCI) is a clinical condition in the continuum between normal cognition and dementia. Despite numerous studies, the heterogeneity of the underlying pathophysiology prevents a precise prediction of clini…
View article: Equating conversion norms for the Mini-Mental State Examination and Montreal Cognitive Assessment in healthy subjects and patients with neurodegenerative disorders
Equating conversion norms for the Mini-Mental State Examination and Montreal Cognitive Assessment in healthy subjects and patients with neurodegenerative disorders Open
Results report easy-to-use conversion norms for transforming raw MMSE score to MoCA and vice versa, highlighting areas were the conversion has a strong or low reliability depending on the score range.
View article: Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review
Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review Open
Introduction Behavioral and Psychological Symptoms of Dementia (BPSD) are common neuropsychiatric manifestations that complicate the clinical course of dementia and impact caregiving. Among these, the Hyperactivity–Impulsivity–Irritiabilit…
View article: Epidemiological Profile of Benign and Malignant Central Nervous System Neoplasms in Brazil: A Decadal Analysis
Epidemiological Profile of Benign and Malignant Central Nervous System Neoplasms in Brazil: A Decadal Analysis Open
Purpose To analyze the epidemiological profile of benign and malignant CNS neoplasm patients in Brazil from 2014 to 2024 to inform public health. Methods A retrospective, cross-sectional study analyzed data from DATASUS on CNS neoplasm hos…
View article: Italian standardization of the BPSD-SINDEM scale for the assessment of neuropsychiatric symptoms in persons with dementia
Italian standardization of the BPSD-SINDEM scale for the assessment of neuropsychiatric symptoms in persons with dementia Open
Introduction Behavioral and Psychological Symptoms of Dementia (BPSD) are a heterogeneous set of psychological reactions and abnormal behaviors in people with dementia (PwD). Current assessment tools, like the Neuropsychiatric Inventory (N…
View article: Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario
Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario Open
The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared to manual recording. Nevertheless, the potential of the information contained within medical records remains large…
View article: Role of fronto-limbic circuit in neuropsychiatric symptoms of dementia: clinical evidence from an exploratory study
Role of fronto-limbic circuit in neuropsychiatric symptoms of dementia: clinical evidence from an exploratory study Open
Background Neuropsychiatric symptoms (NPSs) are a distressful aspect of dementia and the knowledge of structural correlates of NPSs is limited. We aimed to identify associations of fronto-limbic circuit with specific NPSs in patients with …
View article: Gender Differences in Adherence to Dietary Recommendations and Guidelines among Community-Dwelling Older Italian Adults
Gender Differences in Adherence to Dietary Recommendations and Guidelines among Community-Dwelling Older Italian Adults Open
Background and objectives: Adhering to healthy dietary guidelines plays an essential role in maintaining population health, but data on older people exploring the gender dimension are scarce. We aimed to investigate the gender differences …
View article: High Adherence to Mediterranean Diet and Fish Intake Are Inversely Associated with Depressive Symptoms in Older Women: Findings from the Cross-Sectional NutBrain Study
High Adherence to Mediterranean Diet and Fish Intake Are Inversely Associated with Depressive Symptoms in Older Women: Findings from the Cross-Sectional NutBrain Study Open
Background and objectives: Data on the association of Mediterranean diet and food groups with depressive symptoms in older men and women, are scarce. The aim of this study was to examine the cross-sectional association of adherence to the …
View article: Investigating the individual and joint effects of socioeconomic status and lifestyle factors on mild cognitive impairment in older Italians living independently in the community: results from the NutBrain study
Investigating the individual and joint effects of socioeconomic status and lifestyle factors on mild cognitive impairment in older Italians living independently in the community: results from the NutBrain study Open
Trial registration number NCT04461951, date of registration July 7, 2020 (retrospectively registered, ClinicalTrials.gov).
View article: Acute amnestic syndrome in fornix lesions: a systematic review of reported cases with a focus on differential diagnosis
Acute amnestic syndrome in fornix lesions: a systematic review of reported cases with a focus on differential diagnosis Open
Introduction Acute amnestic syndrome is an uncommon clinical presentation of neurological disease. Differential diagnosis encompasses several syndromes including Wernicke-Korsakoff and transient global amnesia (TGA). Structural lesions of …
View article: Retinal and Cortical Visual Processing Dysfunction in a Case of Mild Cognitive Impairment with Lewy Bodies: A Case Report
Retinal and Cortical Visual Processing Dysfunction in a Case of Mild Cognitive Impairment with Lewy Bodies: A Case Report Open
The prodromal stage of Lewy body dementia includes a mild cognitive impairment with visual processing and/or attention-executive deficits. A clinical presentation with progressive visual loss is indeed seldom reported and can be misleading…
View article: APOE 5’UTR Methylation Pattern Analysis in Blood and Brain Tissue from Alzheimer’s Disease Affected Patients
APOE 5’UTR Methylation Pattern Analysis in Blood and Brain Tissue from Alzheimer’s Disease Affected Patients Open
APOE ɛ4 allele is the major genetic risk factor for Alzheimer's Disease (AD). Furthermore, APOE methylation pattern has been described to be associated with the disease and to follow a bimodal pattern, with a hypermethylated CpG island and…
View article: Medical Information Extraction with NLP-Powered QABots: a Real-World Scenario
Medical Information Extraction with NLP-Powered QABots: a Real-World Scenario Open
The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared with manual recording. Nevertheless, the potential of the information contained within medical records remains lar…
View article: BPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden
BPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden Open
Behavioral and Psychological Symptoms of Dementia (BPSD) are a heterogeneous set of psychological and behavioral abnormalities seen in persons with dementia (PwD), significantly impacting their quality of life and that of their caregivers.…
View article: Study of microRNAs and their targets in exosome from Alzheimer’s and Frontotemporal Dementia patients
Study of microRNAs and their targets in exosome from Alzheimer’s and Frontotemporal Dementia patients Open
Background A central role of RNA metabolism and non‐coding RNAs biogenesis has emerged in Alzheimer’s disease (AD) and Frontotemporal Dementia (FTD). We investigated miRNA cargo of Small Extracellular Vesicles (SEVs) derived from plasma of…
View article: Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy
Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy Open
Introduction Polypharmacy (PP) use is very common in older people and may lead to anticholinergic burdens that affect cognitive impairment. We aimed to determine the occurrence of PP, drug-drug interactions (DDIs) and anticholinergic burde…