Catherine Ding
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View article: Rate of motor progression in Parkinson’s disease: a systematic review and meta-analysis
Rate of motor progression in Parkinson’s disease: a systematic review and meta-analysis Open
Background The search for neuroprotective treatments for Parkinson’s disease (PD) still relies largely on motor disability scales. A limitation of these tools is the strong influence of symptomatic dopaminergic treatment effects. Drawing o…
View article: Wearable Accelerometer and Gyroscope Sensors for Estimating the Severity of Essential Tremor
Wearable Accelerometer and Gyroscope Sensors for Estimating the Severity of Essential Tremor Open
Potential applications of this novel wearable sensing method using a wearable Inertial Measurement Unit (IMU) include monitoring of ET and clinical trials of new treatments for the disorder.
View article: Long Term Skeletal, Alveolar, and Dental Expansion Effects of the Midfacial Skeletal Expander
Long Term Skeletal, Alveolar, and Dental Expansion Effects of the Midfacial Skeletal Expander Open
Background: The Midfacial Skeletal Expander (MSE) produces a greater skeletal effect than its dentoalveolar side effects. The aim of this study was to quantify the stability of the different components of MSE expansion post-orthodontic tre…
View article: Using Semiology to Classify Epileptic Seizures vs Psychogenic Nonepileptic Seizures
Using Semiology to Classify Epileptic Seizures vs Psychogenic Nonepileptic Seizures Open
While all signs require an interpretation in the overall clinical context, the presence of ictal eye closure and asynchronous limb movements are reliable discriminative signs for PNES.
View article: Computerised analysis of writing and drawing by essential tremor phenotype
Computerised analysis of writing and drawing by essential tremor phenotype Open
We investigated whether computerised analysis of writing and drawing could discriminate essential tremor (ET) phenotypes according to the 2018 Consensus Statement on the Classification of Tremors. The Consensus scheme emphasises soft addit…
View article: Computerized Screening of Essential Tremor and Level of Severity Using Consumer Tablet
Computerized Screening of Essential Tremor and Level of Severity Using Consumer Tablet Open
Essential tremor (ET) is diagnosed and monitored by movement disorder specialists based on clinical observations. While many ET cases are benign, some require pharmacological and surgical management, and there is a need for tools to assist…
View article: Human perivascular stem cell-derived extracellular vesicles mediate bone repair
Human perivascular stem cell-derived extracellular vesicles mediate bone repair Open
The vascular wall is a source of progenitor cells that are able to induce skeletal repair, primarily by paracrine mechanisms. Here, the paracrine role of extracellular vesicles (EVs) in bone healing was investigated. First, purified human …
View article: Author response: Human perivascular stem cell-derived extracellular vesicles mediate bone repair
Author response: Human perivascular stem cell-derived extracellular vesicles mediate bone repair Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The vascular wall is a source…
View article: Comparison of Human Tissue Microarray to Human Pericyte Transcriptome Yields Novel Perivascular Cell Markers
Comparison of Human Tissue Microarray to Human Pericyte Transcriptome Yields Novel Perivascular Cell Markers Open
Human perivascular progenitor cells, including pericytes, are well-described multipotent mesenchymal cells giving rise to mesenchymal stem cells in culture. Despite the unique location of pericytes, specific antigens to distinguish human p…
View article: Skeletogenic Capacity of Human Perivascular Stem Cells Obtained Via Magnetic-Activated Cell Sorting
Skeletogenic Capacity of Human Perivascular Stem Cells Obtained Via Magnetic-Activated Cell Sorting Open
Human perivascular stem/stromal cells (PSC) are a multipotent mesenchymal progenitor cell population defined by their perivascular residence. PSC are increasingly studied for their application in skeletal regenerative medicine. PSC from su…
View article: Heterotopic Ossification: A Comprehensive Review
Heterotopic Ossification: A Comprehensive Review Open
Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma …
View article: Raised visual contrast thresholds with intact attention and metacognition in functional motor disorder
Raised visual contrast thresholds with intact attention and metacognition in functional motor disorder Open
Functional motor disorders (FMDs) are distinguished by signs that lack congruence with recognised patterns of organic disease and show inconsistency over time. Their pathophysiology is poorly understood, but there is evidence that irregula…
View article: RHI_dataset
RHI_dataset Open
Results of Rubber Hand Illusion in 21 people with Parkinson's disease and 20 healthy controls
View article: Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion
Deep Brain Stimulation for Parkinson’s disease changes perception in the Rubber Hand Illusion Open
Parkinson’s disease (PD) alters cortico-basal ganglia-thalamic circuitry and susceptibility to an illusion of bodily awareness, the Rubber Hand Illusion (RHI). Bodily awareness is thought to result from multisensory integration in a predom…
View article: Early Immunomodulatory Effects of Implanted Human Perivascular Stromal Cells During Bone Formation
Early Immunomodulatory Effects of Implanted Human Perivascular Stromal Cells During Bone Formation Open
Human perivascular stem/stromal cells (PSC) are a multipotent mesodermal progenitor cell population defined by their perivascular residence. PSC are most commonly derived from subcutaneous adipose tissue, and recent studies have demonstrat…
View article: The Implication of Substance P in the Development of Tendinopathy: A Case Control Study
The Implication of Substance P in the Development of Tendinopathy: A Case Control Study Open
It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determ…
View article: Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering
Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering Open
For over 15 years, human subcutaneous adipose tissue has been recognized as a rich source of tissue resident mesenchymal stem/stromal cells (MSC). The isolation of perivascular progenitor cells from human adipose tissue by a cell sorting s…
View article: Effects of WNT3A and WNT16 on the Osteogenic and Adipogenic Differentiation of Perivascular Stem/Stromal Cells
Effects of WNT3A and WNT16 on the Osteogenic and Adipogenic Differentiation of Perivascular Stem/Stromal Cells Open
Human perivascular stem/stromal cells (hPSC) are a multipotent mesenchymogenic stromal cell population defined by their perivascular locale. Recent studies have demonstrated the high potential for clinical translation of this fluorescence-…
View article: Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease
Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease Open
Optokinetic nystagmus (OKN), the reflexive eye movements evoked by a moving field, has recently gained interest among researchers as a useful tool to assess conscious perception. When conscious perception and stimulus are dissociated, such…
View article: Combining Smoothened Agonist and NEL-Like Protein-1 Enhances Bone Healing
Combining Smoothened Agonist and NEL-Like Protein-1 Enhances Bone Healing Open
Background: Nonhealing bone defects represent an immense biomedical burden. Despite recent advances in protein-based bone regeneration, safety concerns over bone morphogenetic protein-2 have prompted the search for alternative factors. Pre…
View article: Study of levodopa response in Parkinson's disease: Observations on rates of motor progression
Study of levodopa response in Parkinson's disease: Observations on rates of motor progression Open
Introduction It is important to understand how the rate of motor progression in PD relates to dopaminergic treatment. Methods The methods for this study comprised prospective defined off state measurements of the levodopa response at 3‐yea…