Thalia C. Eley
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View article: Longitudinal associations between adolescent body dissatisfaction, eating disorder and depressive symptoms, and BMI: a UK twin cohort study
Longitudinal associations between adolescent body dissatisfaction, eating disorder and depressive symptoms, and BMI: a UK twin cohort study Open
Wellcome Trust.
View article: Causation Between Smoking Quantity and Depressive Symptoms in Young Adults: Evidence From Novel Cross-Lagged Twin Models
Causation Between Smoking Quantity and Depressive Symptoms in Young Adults: Evidence From Novel Cross-Lagged Twin Models Open
Background Smoking and depression often co-occur in young adults, potentially due to reciprocal causal effects and/or shared underlying etiological factors. Here, we tested causal hypotheses between smoking quantity (cigarettes per day; Ci…
View article: Neurodevelopmental and Psychosocial Outcomes in Adolescence of Children with Early Diagnoses of ADHD, Autism, Dyscalculia and Dyslexia
Neurodevelopmental and Psychosocial Outcomes in Adolescence of Children with Early Diagnoses of ADHD, Autism, Dyscalculia and Dyslexia Open
The study examined neurodevelopmental and psychosocial outcomes in adolescents aged 12 and 16 with childhood diagnoses of ADHD, autism, dyscalculia, or dyslexia. Participants were drawn from the Twins Early Development Study based on paren…
View article: Internalising problems and self-reported BMI/physical health: Correlated genetic and environmental influences versus probable causal mechanisms
Internalising problems and self-reported BMI/physical health: Correlated genetic and environmental influences versus probable causal mechanisms Open
Internalising problems (depressive and anxiety symptoms) are associated with poor physical health indices. This may reflect causal mechanisms or shared genetic and environmental factors but this has not been previously tested. We tested wh…
View article: UK-based mental health professionals’ perceptions of genetic and environmental risk for psychiatric conditions
UK-based mental health professionals’ perceptions of genetic and environmental risk for psychiatric conditions Open
Objective Psychiatric conditions arise from a complex interplay of genetics and environment. Many people struggle to interpret genetic risk, leading to distress and inadequately informed decisions. Mental health professionals are often the…
View article: Genome-wide association study of adolescent-onset depression
Genome-wide association study of adolescent-onset depression Open
Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide association study of adol…
View article: Combined family history and polygenic score prediction of major depressive disorder
Combined family history and polygenic score prediction of major depressive disorder Open
Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …
View article: Chronotype and psychopathology: insights from a genetically informative design
Chronotype and psychopathology: insights from a genetically informative design Open
Study objectives Chronotype has been linked to a wide variety of psychiatric conditions. In particular, evening chronotype could be a transdiagnostic risk factor for different mental health difficulties. In this study we examine how chrono…
View article: How are children's perceptions of the home environment associated with a general psychopathology factor across childhood?
How are children's perceptions of the home environment associated with a general psychopathology factor across childhood? Open
Background Comorbidity and heterogeneity in psychiatric disorders may stem from a general psychopathology (p) factor influenced by both genetic and environmental factors. Although the relative contributions of these influences on psychopat…
View article: The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development
The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development Open
Neurodevelopmental conditions are highly heritable, heterogeneous, and frequently co-occur with one another. Transdiagnostic dimensional approaches have advanced our understanding of psychiatric disorders and informed their classification,…
View article: The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development
The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development Open
Neurodevelopmental conditions are highly heritable, heterogeneous, and frequently co-occur with one another. Transdiagnostic dimensional approaches have advanced our understanding of psychiatric disorders and informed their classification,…
View article: Genome-wide insights into generalised anxiety using a dimensional symptom severity approach
Genome-wide insights into generalised anxiety using a dimensional symptom severity approach Open
We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of w…
View article: Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder
Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder Open
Introductory paragraph Panic attacks, sudden episodes of intense fear accompanied by physical and psychological symptoms, affect approximately 23% of the population 1,2 . Panic disorder, diagnosed in 2– 4% 3 , involves recurrent attacks fo…
View article: Specificity of polygenic scores for psychiatric disorders beyond transdiagnostic genetic risk (p)
Specificity of polygenic scores for psychiatric disorders beyond transdiagnostic genetic risk (p) Open
Importance: Polygenic scores are increasingly used to estimate genetic liability for psychiatric disorders. However, their limited specificity to the disorders for which they are derived limits their clinical and research utility. Objectiv…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: The UK Biobank mental health enhancement 2022: Methods and results
The UK Biobank mental health enhancement 2022: Methods and results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: The UK Biobank mental health enhancement 2022: Methods and results
The UK Biobank mental health enhancement 2022: Methods and results Open
Background This paper introduces the UK Biobank (UKB) second mental health questionnaire (MHQ2), describes its design, the respondents and some notable findings. UKB is a large cohort study with over 500,000 volunteer participants aged 40–…
View article: Single-item patient-rated helpfulness and improvement as an alternative to standardized questionnaires for establishing anxiety and depression treatment efficacy.
Single-item patient-rated helpfulness and improvement as an alternative to standardized questionnaires for establishing anxiety and depression treatment efficacy. Open
Evidence-based psychological treatments for anxiety and depression are widely used, yet roughly half of those treated do not respond. Treatment response prediction could help to optimize patient outcomes and use of clinical resources. Howe…
View article: Sex-stratified genome-wide association meta-analysis of Major Depressive Disorder
Sex-stratified genome-wide association meta-analysis of Major Depressive Disorder Open
There are striking sex differences in the prevalence and symptomology of Major Depressive Disorder (MDD). We conducted the largest sex-stratified genome wide association and genotype-by-sex interaction meta-analyses of MDD to date (Females…
View article: Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood
Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood Open
Peer problems in childhood and adolescence are associated with anxiety and depression in emerging adulthood. However, it remains unclear whether prosocial behaviours reduce this risk and whether these associations remain after adjusting fo…
View article: Gene-environment interplay in internalising and externalising psychopathology in adolescence
Gene-environment interplay in internalising and externalising psychopathology in adolescence Open
A combination of genetic and environmental factors working in interplay is thought to underlie differences in symptoms of psychopathology between adolescents. Yet, studies that have investigated gene-environment interaction in isolated asp…
View article: Study Preregistration: Clinical and Cognitive Mediators Underlying Subsequent Depression in Individuals With Attention-Deficit/Hyperactivity Disorder: A Developmental Approach
Study Preregistration: Clinical and Cognitive Mediators Underlying Subsequent Depression in Individuals With Attention-Deficit/Hyperactivity Disorder: A Developmental Approach Open
Individuals with attention-deficit/hyperactivity disorder (ADHD) are about 5.5 times more likely to develop depression,1 and this comorbidity is associated with greater impairment than either disorder alone. Although there is evidence that…
View article: The association between body dissatisfaction, depression, eating disorders and BMI: a prospective twin cohort study
The association between body dissatisfaction, depression, eating disorders and BMI: a prospective twin cohort study Open
Introduction Body dissatisfaction is becoming more common among adolescents and is a putative risk factor for adverse mental (e.g., eating disorder and depressive symptoms) and physical health outcomes (e.g., excessive weight gain), both o…
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: Computational modelling reveals slower safety learning and threat extinction are associated with higher anxiety severity in remote fear conditioning
Computational modelling reveals slower safety learning and threat extinction are associated with higher anxiety severity in remote fear conditioning Open
Anxiety disorders are are chronic, pervasive, and debilitating; characterised by a persistent or exaggerated response to distal or abstract threats. Impaired threat discrimination (distinguishing safe from threatening stimuli) and impaired…