Catherine F. Moore
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View article: Effects of oral cannabidiol (CBD) on spontaneous opioid withdrawal in male and female rats
Effects of oral cannabidiol (CBD) on spontaneous opioid withdrawal in male and female rats Open
Opioid use disorder (OUD) remains a public health crisis in the United States. A key factor in continued use, relapse risk, and overdose is the severe withdrawal syndrome that accompanies abstinence. Observational studies suggest cannabis …
View article: Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats
Effects of sex and pre-exposure on Δ9-tetrahydrocannabinol (THC) vapor self-administration in rats Open
Rationale Animal models of cannabinoid self-administration are critical for advancing our understanding of the neurobiology of cannabis use and for developing medications for Cannabis Use Disorder. Use of vapor inhalation models have trans…
View article: Oxytocin decreases alcohol self-administration in male baboons
Oxytocin decreases alcohol self-administration in male baboons Open
The neurohormone oxytocin (OT) has been proposed as a treatment for alcohol and nicotine use disorders. The aim of the present study was to examine whether intravenous (IV) OT decreases alcohol oral self-administration and consumption in n…
View article: Roadmap For The Expression Of Canonical and Extended Endocannabinoid System Receptors and Proteins in Peripheral Organs of Preclinical Animal Models
Roadmap For The Expression Of Canonical and Extended Endocannabinoid System Receptors and Proteins in Peripheral Organs of Preclinical Animal Models Open
The endocannabinoid system is widely expressed throughout the body and is comprised of receptors, ligands, and enzymes that maintain metabolic, immune, and reproductive homeostasis. Increasing interest in the endocannabinoid system has ari…
View article: You are what you vape: Implications of THC chronic self-administration in changes in the gut microbiome of rats
You are what you vape: Implications of THC chronic self-administration in changes in the gut microbiome of rats Open
Vaping of cannabis and its constituents, such as Δ9-tetrahydrocanabinol (THC), has been promoted as a safer alternative to smoked cannabis. Nevertheless, chronic effect of THC vaping in gut microbiome modulation and its effect of health an…
View article: Effects of oral Δ9-tetrahydrocannabinol and cannabidiol combinations on a sustained attention task in rats.
Effects of oral Δ9-tetrahydrocannabinol and cannabidiol combinations on a sustained attention task in rats. Open
A well-documented side effect of cannabis and Δ9-tetrahydrocannabinol (THC) acute administration is deficits in cognition and attention. Cannabidiol (CBD), a nonintoxicating constituent of cannabis, may modulate THC's impairing effects. A …
View article: Δ <sup>9</sup> -Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats
Δ <sup>9</sup> -Tetrahydrocannabinol Vapor Exposure Produces Conditioned Place Preference in Male and Female Rats Open
Background: The use of place conditioning procedures and drug vapor exposure models can increase our understanding of the rewarding and aversive effects of vaped cannabis products. Currently there are limited data on the conditioned reward…
View article: Δ<sup>9</sup>-tetrahydrocannabinol (THC) vapor exposure produces conditioned place preference in male and female rats
Δ<sup>9</sup>-tetrahydrocannabinol (THC) vapor exposure produces conditioned place preference in male and female rats Open
Background The use of place conditioning procedures and drug vapor exposure models can increase our understanding of the rewarding and aversive effects of vaped cannabis products. Currently there are limited data on the conditioned rewardi…
View article: Cannabinoid tetrad effects of oral Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose-effects and time course evaluations
Cannabinoid tetrad effects of oral Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose-effects and time course evaluations Open
Rationale The legalization of medicinal use of Cannabis sativa in most US states and the removal of hemp from the Drug Enforcement Agency (DEA) controlled substances act has resulted in a proliferation of products containing Δ9-tetrahydroc…
View article: Antinociceptive, hypothermic, and appetitive effects of vaped and injected Δ9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex
Antinociceptive, hypothermic, and appetitive effects of vaped and injected Δ9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex Open
Advances in drug vapor exposure systems utilizing e-cigarette technology have enabled evaluation of Δ-9-tetrahydrocannabinol (THC) vapor effects in laboratory animals. The purpose of this study was to 1) establish a range of parameters of …
View article: Impulsive choice does not predict binge-like eating in rats
Impulsive choice does not predict binge-like eating in rats Open
Binge eating disorder is an addiction-like disorder characterized by recurrent, excessive food consumption within discrete periods of time, and it has been linked to increased trait impulsivity. Within impulsivity components, while impulsi…
View article: Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward
Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward Open
Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use. Food intake is in part mediated by reward and reinforcement processes…
View article: Neuroscience of Compulsive Eating Behavior
Neuroscience of Compulsive Eating Behavior Open
A systematic characterization of compulsivity in pathological forms of eating has been proposed in the context of three functional domains: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating d…