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View article: Selection bias in active-control trials: implications for HTAs and recommendations
Selection bias in active-control trials: implications for HTAs and recommendations Open
View article: Simultaneous whole-body multi-parametric 2-[18F]FDG-PET/MRI in smoldering multiple myeloma assessment : diagnostic and prognostic impact
Simultaneous whole-body multi-parametric 2-[18F]FDG-PET/MRI in smoldering multiple myeloma assessment : diagnostic and prognostic impact Open
The co-primary aims of this study were to assess the diagnostic and prognostic performance of Whole-body-2-[18F]-fluorodeoxyglucose-positron emission tomography coupled with MRI (WB-2-[18F]FDG-PET/MRI) imaging in the …
View article: Cost-effectiveness of ten commonly used antipsychotics in first-episode schizophrenia in the UK: economic evaluation based on a <i>de novo</i> discrete event simulation model
Cost-effectiveness of ten commonly used antipsychotics in first-episode schizophrenia in the UK: economic evaluation based on a <i>de novo</i> discrete event simulation model Open
Background Previous economic evidence about interventions for schizophrenia is outdated, non-transparent and/or limited to a specific clinical context. Aims We developed a de novo discrete event simulation (DES) model for estimating the co…
View article: Methods for Indirect Treatment Comparison: Results from a Systematic Literature Review
Methods for Indirect Treatment Comparison: Results from a Systematic Literature Review Open
Introduction: Health technology assessment (HTA) agencies express a clear preference for randomized controlled trials when assessing the comparative efficacy of two or more treatments. However, an indirect treatment comparison (ITC) is oft…
View article: La musique comme outil thérapeutique durant la petite enfance
La musique comme outil thérapeutique durant la petite enfance Open
View article: Heart failure with mildly reduced and preserved ejection fraction: A review of disease burden and remaining unmet medical needs within a new treatment landscape
Heart failure with mildly reduced and preserved ejection fraction: A review of disease burden and remaining unmet medical needs within a new treatment landscape Open
This review provides a comprehensive overview of heart failure with mildly reduced and preserved ejection fraction (HFmrEF/HFpEF), including its definition, diagnosis, and epidemiology; clinical, humanistic, and economic burdens; current p…
View article: The Acceptance of Indirect Treatment Comparison Methods in Oncology by Health Technology Assessment Agencies in England, France, Germany, Italy, and Spain
The Acceptance of Indirect Treatment Comparison Methods in Oncology by Health Technology Assessment Agencies in England, France, Germany, Italy, and Spain Open
The generally low acceptance rate of ITC methods by HTA agencies in oncology suggests that, whilst in the absence of a direct comparison ITCs may provide relevant evidence, this evidence is not widely considered sufficient for the purpose …
View article: New pricing models for generic medicines to ensure long-term sustainable competition in Europe
New pricing models for generic medicines to ensure long-term sustainable competition in Europe Open
Background: Price erosion of generic medicines over time as a result of existing pricing policies in combination with increasing operational costs of these products due to high inflation, undermine long-term sustainable competition in Euro…
View article: Rapid literature review: definition and methodology
Rapid literature review: definition and methodology Open
Introduction: A rapid literature review (RLR) is an alternative to systematic literature review (SLR) that can speed up the analysis of newly published data. The objective was to identify and summarize available information regardin…
View article: Access to innovative drugs and the National Reimbursement Drug List in China: Changing dynamics and future trends in pricing and reimbursement
Access to innovative drugs and the National Reimbursement Drug List in China: Changing dynamics and future trends in pricing and reimbursement Open
Drug public reimbursement in China continues to align more closely with approaches widely used in Europe in terms of HTA, health economics and pricing. Centralization of decision-making processes for public reimbursement of innovative drug…
View article: Effectiveness of onabotulinumtoxinA (BOTOX®) for the preventive treatment of chronic migraine: A meta-analysis on 10 years of real-world data
Effectiveness of onabotulinumtoxinA (BOTOX®) for the preventive treatment of chronic migraine: A meta-analysis on 10 years of real-world data Open
Background This meta-analysis evaluated the real-world effectiveness of onabotulinumtoxinA (BOTOX®), the first preventive treatment FDA-approved specifically for chronic migraine in 2010. Methods We systematically reviewed onabotulinumtoxi…
View article: Preliminary study for intonation classification of imagined speech for brain-computer interface applications
Preliminary study for intonation classification of imagined speech for brain-computer interface applications Open
In the current study, we focused on decoding speech prosody from EEG. Prosody (i.e., melody and rhythm of speech) is important during communication as it allows to convey emotion and meaning. However, it has received little attention in th…
View article: A pilot study for a more Immersive Virtual Reality Brain-Computer Interface
A pilot study for a more Immersive Virtual Reality Brain-Computer Interface Open
We are presenting a pilot study for a more Immersive Virtual Reality (IVR) Brain-Computer Interface (BCI). The originality of our approach lies in the fact of recording, thanks to physical VR trackers, the real movements made by users when…
View article: Correction: Using the Goal Attainment Scale adapted for depression to better understand treatment outcomes in patients with major depressive disorder switching to vortioxetine: a phase 4, single-arm, open-label, multicenter study
Correction: Using the Goal Attainment Scale adapted for depression to better understand treatment outcomes in patients with major depressive disorder switching to vortioxetine: a phase 4, single-arm, open-label, multicenter study Open
View article: Correction to: Using the Goal Attainment Scale adapted for depression to better understand treatment outcomes in patients with major depressive disorder switching to vortioxetine: a phase 4, single-arm, open-label, multicenter study
Correction to: Using the Goal Attainment Scale adapted for depression to better understand treatment outcomes in patients with major depressive disorder switching to vortioxetine: a phase 4, single-arm, open-label, multicenter study Open
Treatment response and remission rates were 65 and 40%, respectively.
View article: Psychometric validation of a patient-reported single-item assessment of ‘Good Day Bad Day’ in a neurogenic orthostatic hypotension population treated with droxidopa
Psychometric validation of a patient-reported single-item assessment of ‘Good Day Bad Day’ in a neurogenic orthostatic hypotension population treated with droxidopa Open
The Good Day Bad Day instrument provided good discrimination at baseline and over time and may aid in assessment of the effects of nOH symptoms on patients.
View article: Using the Goal Attainment Scale adapted for depression to better understand treatment outcomes in patients with major depressive disorder switching to vortioxetine: a phase 4, single-arm, open-label, multicenter study
Using the Goal Attainment Scale adapted for depression to better understand treatment outcomes in patients with major depressive disorder switching to vortioxetine: a phase 4, single-arm, open-label, multicenter study Open
Background Major depressive disorder (MDD) is the leading cause of disability worldwide. Response to pharmacologic treatment is generally evaluated by traditional clinician- and patient-reported rating scales. Assessing therapeutic efficac…
View article: Persistent Daytime Sleepiness after Successful Maxillary-Mandibular Advancement Surgery: A Clinical Case Report
Persistent Daytime Sleepiness after Successful Maxillary-Mandibular Advancement Surgery: A Clinical Case Report Open
Background: Continuous positive airway pressure is a cost-effective treatment of obstructive sleep apnea (OSA), but in case of craniofacial anomalies, which have a recognized role in OSA development, maxillary-mandibular advancement surger…
View article: The Amortization of Funding Gene Therapies: Making the “Intangibles” Tangible for Patients
The Amortization of Funding Gene Therapies: Making the “Intangibles” Tangible for Patients Open
Gene replacement therapies (GRTs) are increasingly expected to reach the market. Current healthcare systems are struggling to fund such valuable, costly therapies. GRTs are highly valuable as they extend life through sustained, long-term e…
View article: A Coq Formalization of Lebesgue Integration of Nonnegative Functions
A Coq Formalization of Lebesgue Integration of Nonnegative Functions Open
Integration, just as much as differentiation, is a fundamental calculus tool that is widely used in many scientific domains. Formalizing the mathematical concept of integration and the associated results in a formal proof assistant helps i…
View article: Stigma in visible skin diseases – a literature review and development of a conceptual model
Stigma in visible skin diseases – a literature review and development of a conceptual model Open
The burden of visible skin diseases (VSDs) includes not only physical symptoms but also psychosocial consequences such as depression, anxiety, impaired quality of life and low self‐esteem. Stigmatization was shown to play a major role in p…
View article: À propos de la ville assiégée: un schéma narratif
À propos de la ville assiégée: un schéma narratif Open
Les ouvrages historiographiques du Moyen Âge peuvent et doivent être envisagés en tant que production littéraire obéissant à des contraintes fortes dépassant les seuls partis‑pris politiques ou idéologiques. L’historien doit, en effet, s’a…
View article: Allocating treatment resources for hepatitis C in the UK: a constrained optimization modelling approach
Allocating treatment resources for hepatitis C in the UK: a constrained optimization modelling approach Open
Background and objective: Although the treatment of chronic hepatitis C (CHC) has significantly evolved with the introduction of direct-acting antivirals, the treatment uptake rates have been low especially among marginalized groups…
View article: Use of Patient Preference Information in Benefit–Risk Assessment, Health Technology Assessment, and Pricing and Reimbursement Decisions: A Systematic Literature Review of Attempts and Initiatives
Use of Patient Preference Information in Benefit–Risk Assessment, Health Technology Assessment, and Pricing and Reimbursement Decisions: A Systematic Literature Review of Attempts and Initiatives Open
Objectives: Inclusion of patient preference (PP) data in decision making has been largely discussed in recent years. Healthcare decision makers-regulatory and health technology assessment (HTA)-are more and more conscious of the nee…
View article: Systematic review of health state utility values used in pharmacoeconomic evaluations for chronic hepatitis C: impact on cost-effectiveness results
Systematic review of health state utility values used in pharmacoeconomic evaluations for chronic hepatitis C: impact on cost-effectiveness results Open
Background Health state utility values (HSUVs) identified from utility elicitation studies are widely used in pharmacoeconomic evaluations for chronic hepatitis C (CHC) and are particularly instrumental in health technology assessment (HTA…
View article: Do not Dispose of Historic Fluid Collections: Evaluating Research Potential and Range of Use
Do not Dispose of Historic Fluid Collections: Evaluating Research Potential and Range of Use Open
The use of specific preservative solutions by museum professionals to maintain fluid-preserved specimens has fluctuated over the years with advances in chemistry. The determining factors for the original choice of solution closely correlat…
View article: Health economic evaluation of gene replacement therapies: methodological issues and recommendations
Health economic evaluation of gene replacement therapies: methodological issues and recommendations Open
Objective: To provide recommendations for addressing previously identified key challenges in health economic evaluations of Gene Replacement Therapies (GRTs), including: 1) the assessment of clinical effectiveness; 2) the valuation …
View article: The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach
The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach Open
Background Parasitic wasps constitute one of the largest group of venomous animals. Although some physiological effects of their venoms are well documented, relatively little is known at the molecular level on the protein composition of th…
View article: Proposition de recommandations sur l’antibioprophylaxie en chirurgie plastique, reconstructrice et esthétique
Proposition de recommandations sur l’antibioprophylaxie en chirurgie plastique, reconstructrice et esthétique Open
View article: PBI10 CHALLENGES IN HEALTH ECONOMIC EVALUATION OF GENE REPLACEMENT THERAPIES: POTENTIAL SOLUTIONS FOR KEY METHODOLOGICAL ISSUES
PBI10 CHALLENGES IN HEALTH ECONOMIC EVALUATION OF GENE REPLACEMENT THERAPIES: POTENTIAL SOLUTIONS FOR KEY METHODOLOGICAL ISSUES Open