Catherine H. Botting
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View article: Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development Open
Ongoing societal changes in views on the medical and recreational roles of cannabis increased the use of concentrated plant extracts with a Δ9-tetrahydrocannabinol (THC) content of more than 90%. Even though prenatal THC exposure is widely…
View article: Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme
Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme Open
Cyanobactin heterocyclases share the same catalytic domain (YcaO) as heterocyclases/cyclodehydratases from other ribosomal peptide (RiPPs) biosynthetic pathways. These enzymes process multiple residues (Cys/Thr/Ser) within the same substra…
View article: Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation
Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation Open
Several candidate biomarkers for baseline prediction of ACI outcome were identified. A holistic overview of the SF proteome in responders and non-responders to ACI has been profiled, providing a better understanding of the biological pathw…
View article: Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology Open
Spinal muscular atrophy (SMA) is an inherited neurodegenerative condition caused by a reduction in the amount of functional survival motor neuron (SMN) protein. SMN has been implicated in transport of mRNA in neural cells for local transla…
View article: Linking Microbial Community Structure and Function During the Acidified Anaerobic Digestion of Grass
Linking Microbial Community Structure and Function During the Acidified Anaerobic Digestion of Grass Open
Harvesting valuable bioproducts from various renewable feedstocks is necessary for the critical development of a sustainable bioeconomy. Anaerobic digestion is a well-established technology for the conversion of wastewater and solid feedst…
View article: Additional file 1: of Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation
Additional file 1: of Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation Open
Table S1. Canonical pathways altered in the synovial fluid of clinical nonresponders at stage I compared with stage II of ACI, identified using Ingenuity Pathway Analysis based on proteins that were identified using iTRAQ proteomics (≥ 1.2…
View article: Not just fat: investigating the proteome of cetacean blubber tissue
Not just fat: investigating the proteome of cetacean blubber tissue Open
Mammalian adipose tissue is increasingly being recognized as an endocrine organ involved in the regulation of a number of metabolic processes and pathways. It responds to signals from different hormone systems and the central nervous syste…
View article: Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology Open
Spinal Muscular Atrophy (SMA) is an inherited neurodegenerative condition caused by reduction in functional Survival Motor Neurones Protein (SMN). SMN has been implicated in transport of mRNA in neural cells for local translation. We previ…
View article: Human interactome of the influenza B virus NS1 protein
Human interactome of the influenza B virus NS1 protein Open
NS1 proteins of influenza A and B viruses share limited sequence homology, yet both are potent manipulators of host cell processes, particularly interferon (IFN) induction. Although many cellular partners are reported for A/NS1, only a few…
View article: Identifying the hydroxyapatite interactome: Involvement of serum proteins in the formation of sub-RPE deposits
Identifying the hydroxyapatite interactome: Involvement of serum proteins in the formation of sub-RPE deposits Open
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
View article: hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases
hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases Open
The maintenance of genomic stability is essential for cellular viability and the prevention of diseases such as cancer. Human single-stranded DNA-binding protein 1 (hSSB1) is a protein with roles in the stabilisation and restart of stalled…
View article: Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+exchanger
Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+exchanger Open
Vacuolar iron transporters (VITs) are a poorly understood family of integral membrane proteins that can function in iron homeostasis via sequestration of labile Fe 2+ into vacuolar compartments. Here we report on the heterologous overexpre…
View article: Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies
Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies Open
The present study reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and expected to have been rigorously assess…
View article: Rapid enzyme regeneration results in the striking catalytic longevity of an engineered, single species, biocatalytic biofilm
Rapid enzyme regeneration results in the striking catalytic longevity of an engineered, single species, biocatalytic biofilm Open
Here we provide the first evidence of a recombinant enzyme's regeneration in an engineered biofilm. The recombinant enzyme was constantly replenished over time as evidenced by dynamic SILAC, which suggests that the engineered E. coli biofi…
View article: Comparative Proteomics Implicates a Role for Multiple Secretion Systems in Electrode-Respiring <i>Geobacter sulfurreducens</i> Biofilms
Comparative Proteomics Implicates a Role for Multiple Secretion Systems in Electrode-Respiring <i>Geobacter sulfurreducens</i> Biofilms Open
Geobacter sulfurreducens is a dissimilatory metal-reducing bacterium capable of forming thick electron-conducting biofilms on solid electrodes. Here, we employ for the first time comparative proteomics to identify key physiological changes…
View article: Rapid evolution and gene expression: a rapidly evolving Mendelian trait that silences field crickets has widespread effects on m<scp>RNA</scp> and protein expression
Rapid evolution and gene expression: a rapidly evolving Mendelian trait that silences field crickets has widespread effects on m<span>RNA</span> and protein expression Open
A major advance in modern evolutionary biology is the ability to start linking phenotypic evolution in the wild with genomic changes that underlie that evolution. We capitalized on a rapidly evolving Hawaiian population of crickets ( Teleo…
View article: On the Interaction Between Human IQGAP1 and Actin
On the Interaction Between Human IQGAP1 and Actin Open
IQGAPs are eukaryotic proteins which integrate signals from various sources and pass these on the cytoskeleton. Understanding how they do this requires information on the interfaces between the proteins. Here, it is shown that the calponin…
View article: Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development
Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development Open
Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences…
View article: CCDC 1468783: Experimental Crystal Structure Determination
CCDC 1468783: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1468784: Experimental Crystal Structure Determination
CCDC 1468784: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1468785: Experimental Crystal Structure Determination
CCDC 1468785: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1468786: Experimental Crystal Structure Determination
CCDC 1468786: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …