Marianne C. Kramer
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View article: Plastid dsRNA transgenes trigger phased small RNA-based gene silencing of nuclear-encoded genes
Plastid dsRNA transgenes trigger phased small RNA-based gene silencing of nuclear-encoded genes Open
Plastid transformation technology has been widely used to express traits of potential commercial importance, though the technology has been limited to traits that function while sequestered in the organelle. Prior research indicates that p…
View article: Plastid double-strand RNA transgenes trigger small RNA-based gene silencing of nuclear-encoded genes
Plastid double-strand RNA transgenes trigger small RNA-based gene silencing of nuclear-encoded genes Open
Plastid transformation technology has been widely used to express traits of potential commercial importance, though the technology has been limited to traits that function while sequestered in the organelle. Prior research indicates that p…
View article: A Conserved Long Intergenic Non-coding RNA Containing snoRNA Sequences, lncCOBRA1, Affects Arabidopsis Germination and Development
A Conserved Long Intergenic Non-coding RNA Containing snoRNA Sequences, lncCOBRA1, Affects Arabidopsis Germination and Development Open
Long non-coding RNAs (lncRNAs) are an increasingly studied group of non-protein coding transcripts with a wide variety of molecular functions gaining attention for their roles in numerous biological processes. Nearly 6,000 lncRNAs have bee…
View article: Data-Independent Acquisition for the Detection of Mononucleoside RNA Modifications by Mass Spectrometry
Data-Independent Acquisition for the Detection of Mononucleoside RNA Modifications by Mass Spectrometry Open
RNA is dynamically modified in cells by a plethora of chemical moieties to modulate molecular functions and processes. Over 140 modifications have been identified across species and RNA types, with the highest density and diversity of modi…
View article: A conserved long intergenic non-coding RNA containing snoRNA sequences, <i>lncCOBRA1</i>, affects Arabidopsis germination and development
A conserved long intergenic non-coding RNA containing snoRNA sequences, <i>lncCOBRA1</i>, affects Arabidopsis germination and development Open
Long non-coding RNAs (lncRNAs) are an increasingly studied group of non-protein-coding transcripts with a wide variety of molecular functions gaining attention for their roles in numerous biological processes. Nearly 6,000 lncRNAs have bee…
View article: N<sup>6</sup>‐methyladenosine and RNA secondary structure affect transcript stability and protein abundance during systemic salt stress in Arabidopsis
N<sup>6</sup>‐methyladenosine and RNA secondary structure affect transcript stability and protein abundance during systemic salt stress in Arabidopsis Open
After transcription, a messenger RNA (mRNA) is further post‐transcriptionally regulated by several features including RNA secondary structure and covalent RNA modifications (specifically N 6 ‐methyladenosine, m 6 A). Both RNA secondary str…
View article: Life After Transcription: Post-Transcriptional Gene Regulation And Non-Coding Rnas During Stress And Development
Life After Transcription: Post-Transcriptional Gene Regulation And Non-Coding Rnas During Stress And Development Open
After transcription, RNAs are tightly regulated through many post-transcriptional processing steps to allow for proper gene expression in a context-specific manner and have a multitude of functions both in their abilities to encode for pro…
View article: Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X
Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X Open
Significance Females have increased immune responsiveness than males, and they are more likely to develop autoimmune disorders. The mechanism underlying these observations is unclear, and hypotheses suggest an important role for the X chro…
View article: Combinatorial control of <i>Drosophila</i> circular RNA expression by intronic repeats, hnRNPs, and SR proteins
Combinatorial control of <i>Drosophila</i> circular RNA expression by intronic repeats, hnRNPs, and SR proteins Open
Thousands of eukaryotic protein-coding genes are noncanonically spliced to produce circular RNAs. Bioinformatics has indicated that long introns generally flank exons that circularize in Drosophila , but the underlying mechanisms by which …
View article: Role of PAR-4 in ovarian cancer
Role of PAR-4 in ovarian cancer Open
Prostate apoptosis response-4 (PAR-4) is considered as a tumour suppressor due to its ability to selectively induce cell apoptosis in most cancer cells. However little is known about the role of PAR-4 in ovarian cancer. In this study, we i…
View article: Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer
Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer Open
CA-125 has been a valuable marker for the follow-up of ovarian cancer patients but it is not sensitive enough to be used as diagnostic marker. We had already used secretomic methods to identify proteins differentially secreted by serous ov…