Catherine L. Worth
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View article: Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord
Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cord Open
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons, yet the cell-type specific molecular alterations within the spinal cords are not well characterized. In this study, …
View article: Polybacterial intracellular coinfection of epithelial stem cells in periodontitis
Polybacterial intracellular coinfection of epithelial stem cells in periodontitis Open
Periodontitis affects billions of people worldwide. To address interkingdom relationships of microbes and niche on periodontitis, we generated the first sin-gle-cell meta-atlas of human periodontium (34-sample, 105918-cell), harmo-nizing 3…
View article: Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules
Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules Open
The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses. Here, we screened avai…
View article: Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies Open
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) convey high risks for the development of heart failure through unknown mechanisms. Using single-nucleus RNA sequencing, we charact…
View article: Higher basal tumor immune activity coupled with a systemic immune response improves liver cancer outcomes
Higher basal tumor immune activity coupled with a systemic immune response improves liver cancer outcomes Open
A holistic understanding of anti-tumor immunity requires examination of systemic immunity beyond the tumor microenvironment. This link between systemic and tumor immune activity is underexplored. We demonstrate that a stronger Type I inter…
View article: Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4 Open
Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze …
View article: Cells of the adult human heart
Cells of the adult human heart Open
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the …
View article: Cells and gene expression programs in the adult human heart
Cells and gene expression programs in the adult human heart Open
Summary Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and strategies to improve therapeutic opportunities require deeper understanding of the molecular processes of the normal hea…
View article: Structural changes of TasA in biofilm formation of <i>Bacillus subtilis</i>
Structural changes of TasA in biofilm formation of <i>Bacillus subtilis</i> Open
Significance Understanding the formation and structure of protective bacterial biofilms will help to design and identify antimicrobial strategies. Our experiments with the secreted major biofilm protein TasA characterize on a molecular lev…
View article: GPCR-SSFE 2.0—a fragment-based molecular modeling web tool for Class A G-protein coupled receptors
GPCR-SSFE 2.0—a fragment-based molecular modeling web tool for Class A G-protein coupled receptors Open
G-protein coupled receptors (GPCRs) are key players in signal transduction and therefore a large proportion of pharmaceutical drugs target these receptors. Structural data of GPCRs are sparse yet important for elucidating the molecular bas…
View article: Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work
Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work Open
The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs). TSHR and its endogenous ligand thyrotropin (TSH) are of essential importance for…