Catherine M. Bulka
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View article: Prenatal exposure to per- and polyfluoroalkyl substances: Association with child behavior in the environmental influences on child health outcomes (ECHO) Cohort
Prenatal exposure to per- and polyfluoroalkyl substances: Association with child behavior in the environmental influences on child health outcomes (ECHO) Cohort Open
We found little evidence of associations between prenatal PFAS exposures and child behavioral problems in the ECHO Cohort. Future studies should consider PFAS exposure during the postnatal period, which may be a more sensitive window.
View article: Florida red tides and adverse birth outcomes: Investigating harmful algae as a novel environmental exposure
Florida red tides and adverse birth outcomes: Investigating harmful algae as a novel environmental exposure Open
Algal blooms have been linked to adverse human health, but little is known about early life exposures. This ecologic study leveraged the 2016-2018 'red tide' blooms to investigate effects on birth outcomes among Florida Gulf coast resident…
View article: Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort
Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort Open
Importance Inorganic arsenic is associated with adverse birth outcomes, but evidence is limited for public water concentrations (modifiable by federal regulatory action) in US populations. Objective To evaluate the association between pren…
View article: Florida Red Tides and Adverse Birth Outcomes: Investigating Harmful Algae as a Novel Environmental Exposure
Florida Red Tides and Adverse Birth Outcomes: Investigating Harmful Algae as a Novel Environmental Exposure Open
View article: Drought exposure during pregnancy and birth outcomes in the Environmental influences on Child Health Outcomes (ECHO) Cohort
Drought exposure during pregnancy and birth outcomes in the Environmental influences on Child Health Outcomes (ECHO) Cohort Open
View article: Good and uninterrupted sleep may be better for eggsCommentary on Zhang Q, Wang Z, Ding J, et al. Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome. <i>J Clin Sleep Med</i> . 2024;20(1):31–38. doi:10.5664/jcsm.10780
Good and uninterrupted sleep may be better for eggsCommentary on Zhang Q, Wang Z, Ding J, et al. Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome. <i>J Clin Sleep Med</i> . 2024;20(1):31–38. doi:10.5664/jcsm.10780 Open
View article: Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age
Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age Open
Prenatal exposure to toxic metals is associated with altered placental function and adverse infant and child health outcomes. Adverse outcomes include those that are observed at the time of birth, such as low birthweight, as well as those …
View article: Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Open
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective …
View article: Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis
Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis Open
The placenta undergoes many changes throughout gestation to support the evolving needs of the foetus. There is also a growing appreciation that male and female foetuses develop differently in utero, with unique epigenetic changes in…
View article: Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns
Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns Open
Importance Preeclampsia, gestational hypertension, and gestational diabetes, the most common pregnancy complications, are associated with substantial morbidity and mortality in mothers and children. Little is known about the biological pro…
View article: Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes Open
Background: Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, and few large studies have focused on autism-related outcomes. We investigated whethe…
View article: Accelerated epigenetic age at birth and child emotional and behavioral development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Accelerated epigenetic age at birth and child emotional and behavioral development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Open
Background: “Epigenetic clocks” have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analyzed results from four prospective U.S cohorts in…
View article: Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis
Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis Open
The placenta undergoes many changes throughout gestation to support the evolving needs of the foetus. There is also a growing appreciation that male and female foetuses develop differently in utero, with unique epigenetic changes in placen…
View article: Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis
Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis Open
The placenta undergoes many changes throughout gestation to support the evolving needs of the foetus. There is also a growing appreciation that male and female foetuses develop differently in utero, with unique epigenetic changes in…
View article: Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Childhood Autism-related Outcomes Open
BACKGROUND: Epidemiologic evidence linking prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with altered neurodevelopment is inconclusive, and few large studies have focused on autism-related outcomes. We investigated whethe…
View article: Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age
Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age Open
Prenatal exposure to toxic metals is associated with altered placental function and adverse infant and child health outcomes. Adverse outcomes include those that are observed at the time of birth, such as low birthweight, as well as those …
View article: Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns
Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns Open
Importance: Preeclampsia, gestational hypertension, and gestational diabetes, the most common pregnancy complications, are associated with substantial morbidity and mortality in mothers and children. Little is known about the biological pr…
View article: Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO
Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO Open
Background: ‘Epigenetic clocks’ have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts in…
View article: Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm
Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm Open
View article: Missing data interpolation in integrative multi-cohort analysis with disparate covariate information
Missing data interpolation in integrative multi-cohort analysis with disparate covariate information Open
Integrative analysis of datasets generated by multiple cohorts is a widely-used approach for increasing sample size, precision of population estimators, and generalizability of analysis results in epidemiological studies. However, often ea…
View article: Placental epigenetic gestational aging in relation to maternal sociodemographic factors and smoking among infants born extremely preterm: a descriptive study
Placental epigenetic gestational aging in relation to maternal sociodemographic factors and smoking among infants born extremely preterm: a descriptive study Open
Social determinants of health (SDoH) are defined as the conditions in which people are born, grow, live, work, and age. The distribution of these conditions is influenced by underlying structural factors and may be linked to adverse pregna…
View article: Prenatal exposure to per- and polyfluoroalkyl substances and childhood autism-related outcomes
Prenatal exposure to per- and polyfluoroalkyl substances and childhood autism-related outcomes Open
View article: Placental Cellular Composition and Umbilical Cord Metal Concentrations: A Descriptive Molecular Epidemiology Study Leveraging DNA Methylation
Placental Cellular Composition and Umbilical Cord Metal Concentrations: A Descriptive Molecular Epidemiology Study Leveraging DNA Methylation Open
Background and Aim: During pregnancy, potentially toxic metals and metalloids can cross the placenta with varying degrees of efficiency. We hypothesized metal toxicokinetics may be regulated by placental cellular composition. Until recentl…
View article: Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study
Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study Open
Background Prenatal exposures to metallic and metalloid trace elements have been linked to altered immune function in animal studies, but few epidemiologic studies have investigated immunological effects in humans. We evaluated the risk of…
View article: Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures
Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures Open
View article: Arsenic in private well water and birth outcomes in the United States
Arsenic in private well water and birth outcomes in the United States Open
In this largest epidemiologic study of arsenic and birth outcomes to date, we did not observe associations of modeled arsenic estimates in private wells with gestational age and found modest inverse associations with term birth weight. Stu…
View article: Metals Mixtures Modeling Identifies Birth Weight-Associated Gene Networks in the Placentas of Children Born Extremely Preterm
Metals Mixtures Modeling Identifies Birth Weight-Associated Gene Networks in the Placentas of Children Born Extremely Preterm Open
View article: Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm
Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm Open
Prenatal exposure to toxic metals is linked to numerous adverse birth and later-in-life outcomes. These outcomes are tied to disrupted biological processes in fetal-derived tissues including the placenta and umbilical cord yet the precise …
View article: Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study
Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study Open
Background Prenatal exposures to metallic and metalloid trace elements have been linked to altered immune function in animal studies, but few epidemiologic studies have investigated immunological effects in humans. We evaluated the risk of…
View article: Placental epigenetic gestational aging in relation to maternal sociodemographic factors and smoking among infants born extremely preterm: a descriptive study
Placental epigenetic gestational aging in relation to maternal sociodemographic factors and smoking among infants born extremely preterm: a descriptive study Open
Social determinants of health (SDoH) are defined as the conditions in which people are born, grow, live, work, and age. The distribution of these conditions is influenced by underlying structural factors and may be linked to adverse pregna…