Catherine Villard
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View article: Brain biomechanics governs mitotic fidelity of embryonic neural progenitors
Brain biomechanics governs mitotic fidelity of embryonic neural progenitors Open
Accurate chromosome segregation is essential to maintain genetic stability and prevent the onset of diseases such as developmental disorders, infertility, and cancer. While many intrinsic factors and processes involved in mitosis have been…
View article: Deformation under flow and morphological recovery of cancer cells
Deformation under flow and morphological recovery of cancer cells Open
A novel microfluidic device dedicated to cell rheology after flow-induced deformation in constricted channel: a focus on the recovery properties of circulating tumor cells.
View article: Surface Tension and Neuronal Sorting in Magnetically Engineered Brain‐Like Tissue
Surface Tension and Neuronal Sorting in Magnetically Engineered Brain‐Like Tissue Open
Engineered 3D brain‐like models have advanced the understanding of neurological mechanisms and disease, yet their mechanical signature, while fundamental for brain function, remains understudied. The surface tension for instance controls b…
View article: Mitochondria: At the crossroads between mechanobiology and cell metabolism
Mitochondria: At the crossroads between mechanobiology and cell metabolism Open
Metabolism and mechanics are two key facets of structural and functional processes in cells, such as growth, proliferation, homeostasis and regeneration. Their reciprocal regulation has been increasingly acknowledged in recent years: exter…
View article: Surface tension drives neuronal sorting in magnetically engineered brain-like tissue
Surface tension drives neuronal sorting in magnetically engineered brain-like tissue Open
Engineered 3D brain-like models have advanced the understanding of neurological mechanisms and disease, yet their mechanical signature, while fundamental for brain function, remains understudied. The surface tension for instance controls b…
View article: Bending stiffness of Candida albicans hyphae reflects adaptive behavior of the fungal cell wall
Bending stiffness of Candida albicans hyphae reflects adaptive behavior of the fungal cell wall Open
The cell wall is a key component of fungi. It constitutes a stiff shell which counteracts internal cell turgor pressure. Its mechanical properties thus contribute to define cell mor- phology. Measurements of the elastic moduli of the funga…
View article: Poly-<scp>l</scp>-lysine/Laminin Surface Coating Reverses Glial Cell Mechanosensitivity on Stiffness-Patterned Hydrogels
Poly-<span>l</span>-lysine/Laminin Surface Coating Reverses Glial Cell Mechanosensitivity on Stiffness-Patterned Hydrogels Open
Brain tissues demonstrate heterogeneous mechanical properties, which evolve with aging and pathologies. The observation in these tissues of smooth to sharp rigidity gradients raises the question of brain cell responses to both different va…
View article: Bending stiffness of <i>Candida albicans</i> hyphae as a proxy of cell wall properties
Bending stiffness of <i>Candida albicans</i> hyphae as a proxy of cell wall properties Open
Hydrodynamic forces applied in a microfluidic device on hyphae of C. albicans allow to measure their bending stiffness in a control situation as well as under various pharmacological, mechanical and genetical perturbations.
View article: Quantitative study of alpha-synuclein prion-like spreading in fully oriented reconstructed neural networks reveals non-synaptic dissemination of seeding aggregates
Quantitative study of alpha-synuclein prion-like spreading in fully oriented reconstructed neural networks reveals non-synaptic dissemination of seeding aggregates Open
The trans-neuronal spread of protein aggregates in a prion-like manner underlies the progression of neuronal lesions in the brain of patients with synucleinopathies such as Parkinson’s disease. Despite being studied actively, the mechanism…
View article: Neuron‐Gated Silicon Nanowire Field Effect Transistors to Follow Single Spike Propagation within Neuronal Network
Neuron‐Gated Silicon Nanowire Field Effect Transistors to Follow Single Spike Propagation within Neuronal Network Open
Silicon nanowire field effect transistors (SiNW‐FETs) provide a local probe for sensing neuronal activity at the subcellular scale, thanks to their nanometer size and ultrahigh sensitivity. The combination with micropatterning or microflui…
View article: Neuron-gated silicon nanowire field effect transistors to follow single spike propagation within neuronal network
Neuron-gated silicon nanowire field effect transistors to follow single spike propagation within neuronal network Open
Silicon nanowire field effect transistors SiNW-FETs provide a local probe for sensing neuronal activity at the subcellular scale, thanks to their nanometer size and ultrahigh sensitivity. The combination with micro-patterning or microfluid…
View article: Neuronal growth from a volume perspective
Neuronal growth from a volume perspective Open
Microfluidic-based fluorescent exclusion method allows to tackle the issue of neuronal growth from a volume perspective. Based on this technology, we studied the two main actin-rich structures accompanying the early stages of neuron develo…
View article: Cellular and Subcellular Contact Guidance on Microfabricated Substrates
Cellular and Subcellular Contact Guidance on Microfabricated Substrates Open
Topography of the extracellular environment is now recognized as a major biophysical regulator of cell behavior and function. The study of the influence of patterned substrates on cells, named contact guidance, has greatly benefited from t…
View article: Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces
Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces Open
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanopa…
View article: Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces
Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces Open
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanopa…
View article: Compromised nuclear envelope integrity drives tumor cell invasion
Compromised nuclear envelope integrity drives tumor cell invasion Open
While mutations leading to a fragile envelope of the cell nucleus are well known to cause diseases such as muscular dystrophies or accelerated aging, the pathophysiological consequences of the recently discovered mechanically induced nucle…
View article: Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in SK-BR-3 and MDA-MB-231 cells
Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in SK-BR-3 and MDA-MB-231 cells Open
Cancer mortality mainly arises from metastases, due to cells that escape from a primary tumor, circulate in the blood as circulating tumor cells (CTCs), permeate across blood vessels and nest in distant organs. It is still unclear how CTCs…
View article: Redox-Triggered Control of Cell Adhesion and Deadhesion on Poly(lysine)-<i>g</i>-poly(ethylene oxide) Adlayers
Redox-Triggered Control of Cell Adhesion and Deadhesion on Poly(lysine)-<i>g</i>-poly(ethylene oxide) Adlayers Open
Spontaneous adsorption of poly(lysine)-g-poly(ethylene glycol) comb-like copolymers (PLL-g-PEG) is a versatile mean to coat substrates with polymer layers that resist cell adhesion. We prepared redox cleavable PLL-g-PEG to switch adhesion …
View article: Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in circulating tumor cells
Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in circulating tumor cells Open
Cancer mortality mainly arises from metastases, due to cells that escape from a primary tumor, circulate in the blood as circulating tumor cells (CTCs), permeate across blood vessels and nest in distant organs. It is still unclear how CTCs…
View article: Topographical cuescontrol the morphology and dynamics of migrating cortical interneurons
Topographical cuescontrol the morphology and dynamics of migrating cortical interneurons Open
In mammalian embryos, cortical interneurons travel long distances among complex three-dimensional tissues before integrating into cortical circuits. Several molecular guiding cues involved in this migration process have been identified, bu…
View article: High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices
High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices Open
Volume is an important parameter regarding physiological and pathological characteristics of neurons at different time scales. Neurons are quite unique cells regarding their extended ramified morphologies and consequently raise several met…
View article: High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices
High-resolution Volume Imaging of Neurons by the Use of Fluorescence eXclusion Method and Dedicated Microfluidic Devices Open
Volume is an important parameter regarding physiological and pathological characteristics of neurons at different time scales. Neurons are quite unique cells regarding their extended ramified morphologies and consequently raise several met…
View article: Geometrical Determinants of Neuronal Actin Waves
Geometrical Determinants of Neuronal Actin Waves Open
Hippocampal neurons produce in their early stages of growth propagative, actin-rich dynamical structures called actin waves. The directional motion of actin waves from the soma to the tip of neuronal extensions has been associated with net…
View article: Influence of topography on cortical interneuron migration in microstructured environments
Influence of topography on cortical interneuron migration in microstructured environments Open
Event Abstract Back to Event Influence of topography on cortical interneuron migration in microstructured environments Claire Leclech1, Rachel Gibel-Russo1, Catherine Villard2 and Christine Métin1* 1 Institut du Fer à Moulin INSERM U839, F…