Cathryn R. Cadwell
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View article: CNSC-40. DECIPHERING CELLULAR TRANSLATION CONTROL IN NEURON-GBM INTERACTIONS
CNSC-40. DECIPHERING CELLULAR TRANSLATION CONTROL IN NEURON-GBM INTERACTIONS Open
The intricate relationship between neurons and cancer cells is critical for tumorigenesis and neuronal dysfunction, however underlying mechanisms and potential therapeutic opportunities are not well-established. Neuron-glioblastoma (GBM) i…
View article: CNSC-96. TARGETING NEURON-GLIOMA CHLORIDE CROSS-TALK IN GLIOBLASTOMA
CNSC-96. TARGETING NEURON-GLIOMA CHLORIDE CROSS-TALK IN GLIOBLASTOMA Open
Neuronal activity and synchrony in both normal and pathological states are regulated by excitatory and inhibitory synaptic inputs, determined by ion channel permeability across the cell membrane. This study investigates neuron-glioma cross…
View article: Glioma-neuronal circuit remodeling induces regional immunosuppression
Glioma-neuronal circuit remodeling induces regional immunosuppression Open
Neuronal activity-driven mechanisms influence glioblastoma cell proliferation and invasion, while glioblastoma remodels neuronal circuits. Although a subpopulation of malignant cells enhances neuronal connectivity, their impact on the immu…
View article: High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing
High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing Open
SUMMARY Single cell genomics has revolutionized our understanding of neuronal cell types. However, scalable technologies for probing single-cell connectivity are lacking, and we are just beginning to understand how molecularly defined cell…
View article: Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus
Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus Open
Prenatal somatic cell gene therapy (PSCGT) could potentially treat severe, early-onset genetic disorders such as spinal muscular atrophy (SMA) or muscular dystrophy. Given the approval of adeno-associated virus serotype 9 (AAV9) vectors in…
View article: Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy
Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy Open
snRNA-seq may be used to infer the cell-type specificity of mosaic chromosomal copy number changes and identify associated gene expression alterations, which in the case of chr1q gain may involve aberrations in cell migration. Future studi…
View article: Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders
Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders Open
View article: Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy
Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy Open
STRUCTURED ABSTRACT Introduction Mosaic gain of chromosome 1q (chr1q) has been associated with malformation of cortical development (MCD) and epilepsy. Hyaline protoplasmic astrocytopathy (HPA) is a rare neuropathological finding seen in c…
View article: Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report
Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report Open
Neuroinvasive infection is the most common cause of meningoencephalitis in people living with human immunodeficiency virus (HIV), but autoimmune etiologies have been reported. We present the case of a 51-year-old man living with HIV infect…
View article: Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma
Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma Open
Composite pleomorphic xanthoastrocytoma-ganglioglioma (PXA-GG) is an extremely rare central nervous system neoplasm with 2 distinct but intermingled components. Whether this tumor represents a “collision tumor” of separate neoplasms or a m…
View article: Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes
Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes Open
Progenitors of the developing human neocortex reside in the ventricular and outer subventricular zones (VZ and OSVZ, respectively). However, whether cells derived from these niches have similar developmental fates is unknown. By performing…
View article: Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report
Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report Open
Background Eosinophilic meningitis is uncommon and often attributed to infectious causes. Case presentation We describe a case of a 72-year-old man who presented with subacute onset eosinophilic meningitis, vasculitis, and intracranial hyp…
View article: Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator
Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator Open
Conversion of glass slides to digital images is necessary to capitalize on advances in computational pathology and could potentially transform our approach to primary diagnosis, research, and medical education. Most slide scanners have a l…
View article: Patch-seq: Past, Present, and Future
Patch-seq: Past, Present, and Future Open
Single-cell transcriptomic approaches are revolutionizing neuroscience. Integrating this wealth of data with morphology and physiology, for the comprehensive study of neuronal biology, requires multiplexing gene expression data with comple…
View article: Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors
Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors Open
View article: Phenotypic variation of transcriptomic cell types in mouse motor cortex
Phenotypic variation of transcriptomic cell types in mouse motor cortex Open
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological and electrophysiological properties 1,2 . Most existing neural taxonomies are based on either transcriptomic 3,4 or morpho-electric 5,6 criteria, as …
View article: Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor Open
The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma, dysembryoplastic neu…
View article: Development of renal cysts in a transplanted kidney
Development of renal cysts in a transplanted kidney Open
View article: Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features
Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features Open
View article: Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex
Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex Open
Clones of excitatory neurons derived from a common progenitor have been proposed to serve as elementary information processing modules in the neocortex. To characterize the cell types and circuit diagram of clonally related excitatory neur…
View article: Abstracts from USCAP 2020: Informatics (1522-1590)
Abstracts from USCAP 2020: Informatics (1522-1590) Open
View article: Abstracts from USCAP 2020: Informatics (1522-1590)
Abstracts from USCAP 2020: Informatics (1522-1590) Open
View article: Author response: Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex
Author response: Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Clones of excitatory neurons derived from …
View article: Phenotypic variation within and across transcriptomic cell types in mouse motor cortex
Phenotypic variation within and across transcriptomic cell types in mouse motor cortex Open
Cortical neurons exhibit astounding diversity in gene expression as well as in morphological and electrophysiological properties. Most existing neural taxonomies are based on either transcriptomic or morpho-electric criteria, as it has bee…
View article: Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma Open
View article: Additional file 1 of Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor
Additional file 1 of Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor Open
Additional file 1: Tables S1–S6.
View article: Author Correction: Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas
Author Correction: Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas
Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas Open
Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing, yet a complete census of its cell types and connectivity remains elusive. Using whole-cell recordings with morphological recovery, we identified o…
View article: Development and Arealization of the Cerebral Cortex
Development and Arealization of the Cerebral Cortex Open
View article: Cell type composition and circuit organization of neocortical radial clones
Cell type composition and circuit organization of neocortical radial clones Open
Summary Excitatory neurons arising from a common progenitor establish radially-oriented clonal units in the neocortex which have been proposed to serve as elementary information processing modules. To characterize the cell types and circui…