Explanipedia

Ambient and passive collection of sleep and circadian data in bipolar disorder to understand symptom trajectories and clinical outcomes (AMBIENT-BD): Study protocol Open

Raahat Manrai, Duncan Swiffen, Cathy Wyse, Debbie Gray, Amy Ferguson , et al. · 2025

Bipolar disorder is defined by extreme variability in mood, activity and sleep/wake patterns. To date, studies of sleep and circadian parameters in bipolar disorder have predominantly relied on short term monitoring over 1-2 weeks, leaving…

Ambient Teens Sleep Study: Protocol for a co-produced feasibility study in adolescents using a contactless radar-based sleep sensor Open

Lorna Caddick, Giulia Gaggioni, Dawn Haughton, Judith Brown, Jo Inchley , et al. · 2024

Sleep is crucial for the healthy development of adolescents, yet many suffer from chronic sleep deprivation. Over the transition to and course of adolescence there are known changes to sleep patterns e.g. shifts towards evening chronotypes…

Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis Open

Shane Crinion, Cathy Wyse, Gary Donohoe, Lorna M. Lopez, Derek W. Morris · 2024

Chronotype is a proxy sleep measure that has been associated with neuropsychiatric disorders. By investigating how chronotype influences risk for neuropsychiatric disorders and vice versa, we may identify modifiable risk factors for each p…

Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal Open

Cathy Wyse, Laura M. Rudderham, Enya A. Nordon, Louise M. Ince, Andrew N. Coogan , et al. · 2024

Molecular timing mechanisms known as circadian clocks drive endogenous 24-h rhythmicity in most physiological functions, including innate and adaptive immunity. Consequently, the response to immune challenge such as vaccination might depen…

Mendelian randomisation analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis Open

Shane Crinion, Cathy Wyse, Gary Donohoe, Lorna M. Lopez, Derek W. Morris · 2023

A wide range of comorbidities have been observed with neuropsychiatric disorders, of which sleep disturbances are one of the most common. Chronotype, a self-reported measurement of an individual’s preference for earlier or later sleep timi…

Guidelines for treating child and adolescent obesity: A systematic review Open

Louise Tully, Niamh Arthurs, Cathy Wyse, Sarah Browne, Lucinda Case , et al. · 2022

Obesity is a chronic disease that compromises the physical and mental health of an increasing proportion of children globally. In high-income countries, prevalence of paediatric obesity is increasing faster in those from marginalised popul…

Susceptibility to the common cold virus is associated with day length Open

Cathy Wyse, Ava C. Clarke, Enya A. Nordon, Collette Murtagh, Alexandra A. Keogh , et al. · 2022

The nosological status of unipolar mania and hypomania within UK Biobank according to objective and subjective measures of diurnal rest and activity Open

Natasha Sangha, Laura M. Lyall, Cathy Wyse, Breda Cullen, Heather C. Whalley , et al. · 2022

Background There is uncertainty whether unipolar mania is a discrete sub‐type of bipolar disorder. Disrupted rest/activity rhythms are a key feature of bipolar disorder (BD) but have not been well characterised in unipolar mania/hypomania …

Evaluating 12 Years of Implementing a Multidisciplinary Specialist Child and Adolescent Obesity Treatment Service: Patient-Level Outcomes Open

Cathy Wyse, Lucinda Case, Órla Walsh, Catherine Shortall, Norah Jordan , et al. · 2022

Introduction Childhood obesity is a chronic disease that requires multidisciplinary and specialist intervention to address its complex pathophysiology, though access to treatment is limited globally. Evaluating the impact of evidence-based…

Susceptibility to Experimental Respiratory Virus Challenge is Associated with Daylength in 1,377 Participants of the Common Cold Project Open

Cathy Wyse, Ava C. Clarke, Enya A. Nordon, Collette Murtagh, A. Keogh , et al. · 2022

46 The sleep, circadian rhythms and mental health in schools (SCRAMS) feasibility study Open

Giulia Gaggioni, Judith Brown, Stella W. Y. Chan, Breda Cullen, Michael Farquhar , et al. · 2021

1Abstract The inference of biological relatedness from DNA sequence data has a wide array of applications, such as in the study of human disease, anthropology and ecology. One of the most common analytical frameworks for performing this in…

Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort Open

Cathy Wyse, Grace O’Malley, Andrew N. Coogan, Samuel McConkey, Daniel J. Smıth · 2021

Accelerometry-assessed sleep duration and timing in late childhood and adolescence in Scottish schoolchildren: A feasibility study Open

Laura M. Lyall, Natasha Sangha, Cathy Wyse, Elaine Hindle, Dawn Haughton , et al. · 2020

Children and adolescents commonly suffer from sleep and circadian rhythm disturbances, which may contribute to poorer mental health and wellbeing during this critical developmental phase. Many studies however rely on self-reported sleep me…

Seasonal and Daytime Variation in Multiple Immune Parameters in Humans: Evidence from 329,261 Participants of the UK Biobank Cohort Open

Cathy Wyse, Grace O’Malley, Andrew N. Coogan, Daniel J. Smıth · 2020

Background Seasonal disease outbreaks are perennial features of human infectious disease but the factors generating these patterns are unclear. In animal studies, seasonal and circadian (daily) rhythms in immune function generate periodici…

Exosomes as Biomarkers of Human and Feline Mammary Tumours; A Comparative Medicine Approach to Unravelling the Aggressiveness of TNBC Open

Jane Howard, Cathy Wyse, David J. Argyle, Cecily Quinn, Pamela Kelly , et al. · 2020

Comparative oncology is defined as the discipline that integrates naturally occurring cancers seen in veterinary medicine, into more general studies of cancer biology and therapy in humans, including the study of cancer-pathogenesis and ne…

Accelerometry-assessed sleep duration and timing in late childhood and adolescence in Scottish schoolchildren: a feasibility study Open

Laura M. Lyall, Natasha Sangha, Cathy Wyse, Elaine Hindle, Dawn Haughton , et al. · 2020

Children and adolescents commonly suffer from sleep and circadian rhythm disturbances, which may contribute to poorer mental health and wellbeing during this critical developmental phase. Many studies however rely on self-reported sleep me…

Exosomes in triple negative breast cancer: Garbage disposals or Trojan horses? Open

Chia Yin Goh, Cathy Wyse, Matthew Ho, Ellen O’Beirne, Jane Howard , et al. · 2020

Triple negative breast cancer (TNBC) is a breast cancer subtype which is particularly aggressive and invasive. The treatment of TNBC has been limited due to the lack of well-defined molecular targets. Exosomes are nano-sized extracellular …

How data science can advance mental health research Open

Tom C. Russ, Eva Woelbert, Katrina A. S. Davis, Jonathan D. Hafferty, Zina Ibrahim , et al. · 2018

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 Open

James O. Early, Deepthi Menon, Cathy Wyse, Mariana P. Cervantes‐Silva, Zbigniew Zasłona , et al. · 2018

Significance The molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment. The response of the innate immune system to pathogenic threats is dependent on tim…

Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability Open

Amy Ferguson, Laura M. Lyall, Joey Ward, Rona J. Strawbridge, Breda Cullen , et al. · 2018

Genome-wide association study of circadian rhythmicity in 71 500 UK Biobank participants and polygenic association with mood instability Open

Amy Ferguson, Laura M. Lyall, Joey Ward, Rona J. Strawbridge, Breda Cullen , et al. · 2018

Background Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods W…

Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK biobank Open

Cathy Wyse, Carlos A. Celis Morales, Joey Ward, Donald M. Lyall, Daniel J. Smıth , et al. · 2018

The risk of CVD may be modulated by day length at temperate latitudes, and the implications of seasonality should be considered in all studies of human cardiometabolic health. Key messages In this cross-sectional study in UK Biobank, we re…

Tobacco exposure and sleep disturbance in 498 208 UK Biobank participants Open

Daniel Boakye, Cathy Wyse, Carlos Celis‐Morales, Stephany M. Biello, Mark E.S. Bailey , et al. · 2017

Background The prevalence of sleep disturbance is high and increasing. The study investigated whether active, former and passive smoking were associated with sleep disturbance. Methods This cross-sectional study used data from the UK Bioba…

Correction: First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio) Open

Sohye Yoon, Suman K. Mitra, Cathy Wyse, Ayham Alnabulsi, Jun Zou , et al. · 2016

[This corrects the article DOI: 10.1371/journal.pone.0126378.].

Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats Open

Ku Mastura Ku Mohd Noor, Cathy Wyse, Lisa A. Roy, Stephany M. Biello, Christopher McCabe , et al. · 2016

Photoperiod disruption, which occurs during shift work, is associated with changes in metabolism or physiology (e.g. hypertension and hyperglycaemia) that have the potential to adversely affect stroke outcome. We sought to investigate if p…

Effects of Photoperiod Extension on Clock Gene and Neuropeptide RNA Expression in the SCN of the Soay Sheep Open

Hugues Dardente, Cathy Wyse, G. A. Lincoln, Gabriela Wagner, David G. Hazlerigg · 2016

In mammals, changing daylength (photoperiod) is the main synchronizer of seasonal functions. The photoperiodic information is transmitted through the retino-hypothalamic tract to the suprachiasmatic nuclei (SCN), site of the master circadi…

Increased Expression of Microglial Markers in the Arcuate Nucleus of Mice Exposed to Dim Light at Night Open

Cathy Wyse, Lieve Desbonnet, N. Kangasmaa, Alan J. Russell, SM Biello · 2016

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First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio) Open

Sohye Yoon, Suman Mitra, Cathy Wyse, Ayham Alnabulsi, Jun Zou , et al. · 2015

Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess cells that express TcR and CD4-related genes (that…

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