C. Morris
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View article: Stereoselective synthesis of atropisomeric amides enabled by intramolecular acyl transfer
Stereoselective synthesis of atropisomeric amides enabled by intramolecular acyl transfer Open
A stereoselective strategy to make C–N atropisomeric amides based on intramolecular acyl transfer via a tethered Lewis basic pyridine or tertiary amine group is reported.
View article: Recurrent <i>Klebsiella</i> bacteremia due to chronic strongyloidiasis in the context of cirrhotic hepatopulmonary syndrome
Recurrent <i>Klebsiella</i> bacteremia due to chronic strongyloidiasis in the context of cirrhotic hepatopulmonary syndrome Open
A woman in her 50s with a medical history of cirrhosis, alcohol use disorder, primary biliary cholangitis and extended spectrum beta lactamase (ESBL) Klebsiella presented with weakness, cough and abdominal pain with positive blood cultures…
View article: Plasma circulating tumor DNA analysis (ctDNA) for molecular alteration detection in advanced non-small cell lung cancer (NSCLC) patients (pts) with isolated central nervous system (CNS) metastases (mts)
Plasma circulating tumor DNA analysis (ctDNA) for molecular alteration detection in advanced non-small cell lung cancer (NSCLC) patients (pts) with isolated central nervous system (CNS) metastases (mts) Open
Background: In advanced NSCLC, ctDNA is an emerging tool in molecular profile testing at diagnosis and at resistance to targeted therapies. However, for CNS limited mts, ctDNA might have a reduced accuracy because of low concentrations. Ai…
View article: Clinical outcomes in patients with advanced NSCLC treated with targeted therapies, with actionable mutations identified by InVisionFirst ctDNA assay
Clinical outcomes in patients with advanced NSCLC treated with targeted therapies, with actionable mutations identified by InVisionFirst ctDNA assay Open
Background: ctDNA-based molecular profiling of advanced cancer patients with multi-gene next-generation sequencing (NGS) panels is rapidly gaining traction in clinical practice given faster results and more comprehensive stratification. Ho…
View article: Clinical validation and utility of InVision ctDNA in advanced non-small cell lung cancer (NSCLC) patients
Clinical validation and utility of InVision ctDNA in advanced non-small cell lung cancer (NSCLC) patients Open
Background: Molecular profiling using liquid biopsy ctDNA is rapidly gaining traction in routine clinical practice. However, there has been variable degree of accuracy and performance published to date and lack of prospective data on clini…