Catrin Roolf
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View article: <scp>KMT</scp> 2 <scp>A</scp> degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
<span>KMT</span> 2 <span>A</span> degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells Open
Hypermethylation of tumor suppressor genes is a hallmark of leukemia. The hypomethylating agent decitabine covalently binds, and degrades DNA (cytosine‐5)‐methyltransferase 1 (DNMT1). Structural similarities within DNA‐binding domains of D…
View article: Abdominal venous thromboses: detection of the JAK2 p.V617F mutation by next-generation ultradeep sequencing—A prevalence study of patients in Mecklenburg-West Pomerania (2017–2021)
Abdominal venous thromboses: detection of the JAK2 p.V617F mutation by next-generation ultradeep sequencing—A prevalence study of patients in Mecklenburg-West Pomerania (2017–2021) Open
Background Abdominal venous thromboses are rare thrombotic events with heterogeneous etiologies. They are related to myeloproliferative neoplasms (MPNs) in some patients and can occur as first signs of the disease. MPNs are characterized b…
View article: Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse
Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse Open
Little is known about optimally applying chemotherapeutic agents in a specific temporal sequence to rapidly reduce the tumor load and to improve therapeutic efficacy. The clinical optimization of drug efficacy while reducing side effects i…
View article: The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models
The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models Open
In acute lymphoblastic leukemia (ALL), conventional cell lines do not recapitulate the clonal diversity and microenvironment. Orthotopic patient-derived xenograft models (PDX) overcome these limitations and mimic the clinical situation, bu…
View article: Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia
Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia Open
Aberrant PI3K/AKT signaling is a hallmark of acute B-lymphoblastic leukemia (B-ALL) resulting in increased tumor cell proliferation and apoptosis deficiency. While previous AKT inhibitors struggled with selectivity, MK-2206 promises meticu…
View article: PDA Indolylmaleimides Induce Anti-Tumor Effects in Prostate Carcinoma Cell Lines Through Mitotic Death
PDA Indolylmaleimides Induce Anti-Tumor Effects in Prostate Carcinoma Cell Lines Through Mitotic Death Open
Castrate resistant prostate cancer in men shares several characteristics with canine prostate cancer (PCa). Due to current insufficient therapies, evaluating novel therapeutic agents for late-stage PCa is of considerable interest for both …
View article: Additional file 4 of Combination of the PI3K inhibitor Idelalisib with the conventional cytostatics cytarabine and dexamethasone leads to changes in pathway activation that induce anti-proliferative effects in B lymphoblastic leukaemia cell lines
Additional file 4 of Combination of the PI3K inhibitor Idelalisib with the conventional cytostatics cytarabine and dexamethasone leads to changes in pathway activation that induce anti-proliferative effects in B lymphoblastic leukaemia cell lines Open
Additional file 4. xls-file. Additional data of the top-50 regulated pathways and top-20 regulated genes, as well as comparison to existing reference data.
View article: Additional file 7: of Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia
Additional file 7: of Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia Open
Table S6. List of genes that were hypomethylated after combined CX-4945 and DEC incubation (FC<0.25) compared to controls. (XLSX 48 kb)
View article: Additional file 6: of Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia
Additional file 6: of Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia Open
Table S5. List of genes that were hypomethylated after CX-4945 incubation (FC<0.25) compared to controls. (XLSX 11 kb)
View article: CCDC 1869607: Experimental Crystal Structure Determination
CCDC 1869607: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Additional File 10:
Additional File 10: Open
Table S8. List of Biological processes regulated by combined CX-4945 and DEC incubation. (XLSX 13 kb)
View article: Additional file 8: of Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia
Additional file 8: of Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia Open
Table S7. List of Biological processes regulated by CX-4945 incubation. (XLSX 15 kb)
View article: Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice
Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice Open
Engraftment rates of primary adult acute lymphoblastic leukemia samples are studied.
View article: Additional file 2: of Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements
Additional file 2: of Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements Open
Methylation-specific quantitative PCR. (MSqPCR) (DOCX 15Â kb)
View article: Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells
Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells Open
Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. S…
View article: Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells
Polymorphism in Murine mtATP8 Gene Correlates with Decreased Reactive Oxygen Species in Aging Hematopoietic Cells Open
The investigated polymorphism is associated with decreased ROS levels in aged hematopoietic cells but does not significantly influence hematopoiesis itself.
View article: Polymorphisms of the murine mitochondrial <i>ND4</i>, <i>CYTB</i> and <i>COX3</i> genes impact hematopoiesis during aging
Polymorphisms of the murine mitochondrial <i>ND4</i>, <i>CYTB</i> and <i>COX3</i> genes impact hematopoiesis during aging Open
During aging, mitochondrial DNA (mtDNA) can accumulate mutations leading to increasing levels of reactive oxygen species (ROS). Increased ROS were described to activate formerly quiescent hematopoietic stem cells (HSC). Mutations in mtDNA …
View article: Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells
Characterization of the novel indolylmaleimides' PDA-66 and PDA-377 effect on canine lymphoma cells Open
Protein kinase inhibitors are widely used in chemotherapeutic cancer regimens. Maleimide derivatives such as SB-216763 act as GSK-3 inhibitor targeting cell proliferation, cell death and cell cycle progression.Herein, the two arylindolylma…
View article: Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation
Kinetics of Langerhans cell chimerism in the skin of dogs following 2 Gy TBI allogeneic hematopoietic stem cell transplantation Open
Our study indicates that LC donor chimerism correlates with chimerism development in the peripheral blood but occurs delayed following NM-HSCT.