Cavan Bennett
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View article: Characterisation of the megakaryocyte proteome in patients with Philadelphia negative myeloproliferative neoplasms
Characterisation of the megakaryocyte proteome in patients with Philadelphia negative myeloproliferative neoplasms Open
Introduction: Megakaryocytes are considered to drive pathology in the classical Philadelphia-negative myeloproliferative neoplasms (MPNs). The distinct cellular and spatial morphological abnormalities of megakaryocytes in each MPN (primary…
View article: Host iron deficiency protects against <i>Plasmodium</i> infection and drives parasite molecular reprofiling
Host iron deficiency protects against <i>Plasmodium</i> infection and drives parasite molecular reprofiling Open
Iron deficiency, anemia and Plasmodium infection represent significant global health challenges with overlapping geographical distributions, particularly affecting pregnant women in Africa, yet the mechanisms underlying their interactions …
View article: Maternal Tmprss6 is required for hepcidin suppression and fetal health
Maternal Tmprss6 is required for hepcidin suppression and fetal health Open
The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated as knockout dams are infertile. Utilising an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tm…
View article: Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a substudy to a randomized controlled trial
Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a substudy to a randomized controlled trial Open
Immediate effects of MNPs on child hemoglobin and iron status are larger among those with low compared with not-low hepcidin, indicating that preintervention screening could help identify those who would benefit most from MNPs. This trial …
View article: Serum iron and transferrin saturation variation are circadian regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic <scp><i>Tfrc</i></scp> expression in mice
Serum iron and transferrin saturation variation are circadian regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic <span><i>Tfrc</i></span> expression in mice Open
Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic iron status. Circadian regulation (endogenous ~24‐h periodic oscillation of a biologic function) governs many …
View article: Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to<i>Plasmodium falciparum</i>
Spatial analysis of Hofbauer cell transcriptome, distribution and morphology in placentas exposed to<i>Plasmodium falciparum</i> Open
Placental infection remains a significant health burden for mothers and their babies in low-income countries, especially in sub-Saharan Africa, where malaria transmission is intense. An increase in inflammatory biomarkers and poor vascular…
View article: Iron deficiency, pregnancy, and neonatal development
Iron deficiency, pregnancy, and neonatal development Open
Anemia affects 36% of pregnant women worldwide. Of those affected, around 40% is due to iron deficiency (ID). Iron is an essential micronutrient involved in vital processes such as erythropoiesis, immune responses, and importantly—during p…
View article: Serum iron variation is circadian-regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic<i>Tfrc</i>expression in mice
Serum iron variation is circadian-regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic<i>Tfrc</i>expression in mice Open
Serum iron has long been thought to exhibit diurnal variation and is subsequently considered an unreliable biomarker of systemic iron status. Circadian regulation (endogenous ∼24-hour periodic oscillation of a biologic function) governs ma…
View article: Iron homeostasis governs erythroid phenotype in Polycythemia Vera
Iron homeostasis governs erythroid phenotype in Polycythemia Vera Open
Polycythemia Vera (PV) is a myeloproliferative neoplasm driven by activating mutations in JAK2 that result in unrestrained erythrocyte production, increasing patients' hematocrit and hemoglobin concentration, placing them at risk of life-t…
View article: Iron homeostasis governs erythroid phenotype in Polycythemia Vera
Iron homeostasis governs erythroid phenotype in Polycythemia Vera Open
Polycythemia Vera (PV) is a myeloproliferative neoplasm driven by activating mutations in JAK2 that result in unrestrained erythrocyte production, increasing patients’ hematocrit and hemoglobin concentration, placing them at risk of life-t…
View article: CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia
CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia Open
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count…
View article: Zinc Supplementation with or without Additional Micronutrients Does Not Affect Peripheral Blood Gene Expression or Serum Cytokine Level in Bangladeshi Children
Zinc Supplementation with or without Additional Micronutrients Does Not Affect Peripheral Blood Gene Expression or Serum Cytokine Level in Bangladeshi Children Open
Preventive zinc supplementation provided as a stand-alone dispersible tablet, or via home fortification as multiple micronutrient powders (MNPs), has been considered a potential strategy to prevent zinc deficiency and improve health (inclu…
View article: Mechanisms, mishaps and manipulation of iron uptake
Mechanisms, mishaps and manipulation of iron uptake Open
Take home messages Disorders in systemic iron regulation or intestinal iron absorption can result in functional or absolute iron deficiency or iron overload. A generation of pharmaceuticals are now entering clinical trials aimed at manipul…
View article: Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice
Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice Open
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View article: Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in <i>Bmpr2</i>‐deficient mice
Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in <i>Bmpr2</i>‐deficient mice Open
Increasing evidence suggests that patients with pulmonary arterial hypertension (PAH) demonstrate abnormalities in the bone marrow (BM) and hematopoietic progenitor cells. In addition, PAH is associated with myeloproliferative diseases. We…
View article: Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage
Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage Open
Key Points Mutant CALR drives ET and MF in knockin mice. Mutant CALR expression results in expansion of phenotypic HSCs without a self-renewal advantage.
View article: Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia Open
Thrombocythaemia is defined as a circulating platelet count above 450x10$^9$/L in humans. The major cause of thrombocythaemia is reactive $(secondary)$ thrombocythaemia which occurs secondary to many conditions such as infection, cancer an…
View article: Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity
Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity Open
Objective— Platelets are increasingly implicated in processes beyond hemostasis and thrombosis, such as vascular remodeling. Members of the matrix metalloproteinase (MMP) family not only remodel the extracellular matrix but also modulate p…