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View article: Pollen‐Inspired Aptamer Delivery System for Multi‐Target Therapy in Rheumatoid Arthritis
Pollen‐Inspired Aptamer Delivery System for Multi‐Target Therapy in Rheumatoid Arthritis Open
In rheumatoid arthritis (RA), the complex interplay of inflammatory mediators and cellular mechanisms presents challenges for effective treatment. Current therapies, often targeting singular pathways, achieve limited clinical remission. Th…
View article: Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects
Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects Open
Osteoporotic bone defects are challenging to repair due to imbalances in bone resorption and formation, coupled with insufficient vascularization. To address these issues, it develops a trifunctional hydrogel (SF‐ZIF@NA) designed to select…
View article: Osteoclast-derived apoptotic bodies accelerate the pathological progression of osteoarthritis via disturbing subchondral bone remodeling
Osteoclast-derived apoptotic bodies accelerate the pathological progression of osteoarthritis via disturbing subchondral bone remodeling Open
View article: ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm
ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm Open
Oxidative stress, particularly ROS accumulation, plays a key role in the development of abdominal aortic aneurysm (AAA). Surgical treatments and current drugs for AAA have limitations, including lack of specificity and significant side eff…
View article: LL-37 and bisphosphonate co-delivery 3D-scaffold with antimicrobial and antiresorptive activities for bone regeneration
LL-37 and bisphosphonate co-delivery 3D-scaffold with antimicrobial and antiresorptive activities for bone regeneration Open
This study introduces a novel 3D scaffold for bone regeneration, composed of silk fibroin, chitosan, nano-hydroxyapatite, LL-37 antimicrobial peptide, and pamidronate. The scaffold addresses a critical need in bone tissue engineering by si…
View article: Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the “microbiota-gut-joint” axis
Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the “microbiota-gut-joint” axis Open
View article: Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis
Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis Open
The interleukin 6 (IL6) signaling pathway plays pleiotropic roles in regulating the inflammatory milieu that contributes to arthritis development. Here, we show that activation of IL6 trans-signaling induces phenotypic transitions in tissu…
View article: Bile acid metabolism regulatory network orchestrates bone homeostasis
Bile acid metabolism regulatory network orchestrates bone homeostasis Open
Bile acids (BAs), synthesized in the liver and modified by the gut microbiota, have been widely appreciated not only as simple lipid emulsifiers, but also as complex metabolic regulators and momentous signaling molecules, which play promin…
View article: Osteoclast-derived apoptotic bodies inhibit naive CD8+ T cell activation via Siglec15, promoting breast cancer secondary metastasis
Osteoclast-derived apoptotic bodies inhibit naive CD8+ T cell activation via Siglec15, promoting breast cancer secondary metastasis Open
The bone microenvironment promotes cancer cell proliferation and dissemination. During periodic bone remodeling, osteoclasts undergo apoptosis, producing large numbers of apoptotic bodies (ABs). However, the biological role of osteoclast-d…
View article: Reduced osteoclast-derived apoptotic bodies in bone marrow characterizes the pathological progression of osteoporosis
Reduced osteoclast-derived apoptotic bodies in bone marrow characterizes the pathological progression of osteoporosis Open
Osteoporosis is associated with excessive activity of osteoclasts. In bone turn over, most osteoclasts undergo apoptosis after bone resorption and produce a large number of apoptotic bodies (ABs). However, the biological function of osteoc…
View article: Gold-nanosphere mitigates osteoporosis through regulating TMAO metabolism in a gut microbiota-dependent manner
Gold-nanosphere mitigates osteoporosis through regulating TMAO metabolism in a gut microbiota-dependent manner Open
Osteoporosis (OP) is a metabolic bone disease characterized by decreased bone mass and increased bone fragility. The imbalance of bone homeostasis modulated by osteoclasts and osteoblasts is the most crucial pathological change in osteopor…
View article: Ghost messages: cell death signals spread
Ghost messages: cell death signals spread Open
Cell death is a mystery in various forms. Whichever type of cell death, this is always accompanied by active or passive molecules release. The recent years marked the renaissance of the study of these molecules showing they can signal to a…
View article: Endothelial Cells Promote Migration of Mesenchymal Stem Cells via PDGF-BB/PDGFRβ-Src-Akt in the Context of Inflammatory Microenvironment upon Bone Defect
Endothelial Cells Promote Migration of Mesenchymal Stem Cells via PDGF-BB/PDGFRβ-Src-Akt in the Context of Inflammatory Microenvironment upon Bone Defect Open
Homing of mesenchymal stem cells (MSCs) to the defect site is indispensable for bone repair. Local endothelial cells (ECs) can recruit MSCs; however, the mechanism remains unclear, especially in the context of the inflammatory microenviron…
View article: Sialylation of TLR2 initiates osteoclast fusion
Sialylation of TLR2 initiates osteoclast fusion Open
View article: Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system
Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system Open
View article: Osteoclast-Derived Apoptotic Bodies Inhibit Naive Cd8 <sup> </sup> T Cell Activation via Siglec15 Promoting Breast Cancer Secondary Metastasis
Osteoclast-Derived Apoptotic Bodies Inhibit Naive Cd8 <sup> </sup> T Cell Activation via Siglec15 Promoting Breast Cancer Secondary Metastasis Open
View article: An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion
An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion Open
View article: Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases
Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases Open
View article: Klotho upregulates the interaction between RANK and TRAF6 to facilitate RANKL-induced osteoclastogenesis via the NF-κB signaling pathway
Klotho upregulates the interaction between RANK and TRAF6 to facilitate RANKL-induced osteoclastogenesis via the NF-κB signaling pathway Open
Klotho promotes RANKL-induced osteoclastogenesis through upregulating the interaction between RANK and TARF6, Targeting on klotho may be an attractive therapeutic method for osteopenic diseases.
View article: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization
Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization Open
Adv. Sci. 2018, 5, 1700578 DOI: 10.1002/advs.201700578 In the originally published article, there is an error in Figure 3c, in which the representative bone slice bone resorption images were incorrect. The corrected figure is shown below. …
View article: Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis
Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis Open
Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis, which function mainly through an overall inhibition of osteoclast. However, not all osteoclasts are "bone eaters"; preosteoclasts (pOCs) play an…
View article: Light rare earth elements hinder bone development via inhibiting type H vessels formation in mice
Light rare earth elements hinder bone development via inhibiting type H vessels formation in mice Open
Light rare earth elements (LREEs) are widely used in medical, industrial, and agricultural fields. Wide application of light rare earth and exposure to these elements in human society leads to increasing accumulation of LREE in human skele…
View article: Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1
Osteoclast-derived small extracellular vesicles induce osteogenic differentiation via inhibiting ARHGAP1 Open
View article: Small extracellular vesicles deliver osteolytic effectors and mediate cancer‐induced osteolysis in bone metastatic niche
Small extracellular vesicles deliver osteolytic effectors and mediate cancer‐induced osteolysis in bone metastatic niche Open
Extracellular vesicles (EVs) play critical roles in regulating bone metastatic microenvironment through mediating intercellular crosstalks. However, little is known about the contribution of EVs derived from cancer cells to the vicious cyc…
View article: Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling
Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling Open
View article: Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis Open
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been considered as primarily a disease of the articular cartilage, the participation of subchondral bone in the pathogenesis of OA has attracted increasing…
View article: Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p
Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p Open
View article: Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis
Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis Open
View article: Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling
Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling Open
We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinfo…
View article: Osteoclast-derived apoptotic bodies show extended biological effects of parental cell in promoting bone defect healing
Osteoclast-derived apoptotic bodies show extended biological effects of parental cell in promoting bone defect healing Open
Apoptotic bodies (ABs) traditionally considered as garbage bags that enclose residual components of dead cells are gaining increasing attentions due to their potential roles in intercellular communications. In bone turn over, at the end of…