Christa E Flueck
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View article: EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology
EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology Open
Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal …
View article: EndoCompass Project: Research Roadmap for Reproductive and Developmental Endocrinology
EndoCompass Project: Research Roadmap for Reproductive and Developmental Endocrinology Open
Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal im…
View article: Early Life Intervention in Paediatrics Supported by E-Health (ELIPSE)—a coaching app for parents to reduce obesity and second-hand smoke exposure in children: study protocols for two parallel-group randomised controlled trials
Early Life Intervention in Paediatrics Supported by E-Health (ELIPSE)—a coaching app for parents to reduce obesity and second-hand smoke exposure in children: study protocols for two parallel-group randomised controlled trials Open
Background Family lifestyle factors—such as physical activity, diet and parental smoking—are key modifiable determinants for child health. Physical inactivity and calorie-dense diets contribute to obesity, which is linked to 75% of all non…
View article: Serum and hair steroid profiles and their associations with body composition in adolescence
Serum and hair steroid profiles and their associations with body composition in adolescence Open
Objective Accurate assessment of steroid hormones is essential for understanding sexual development and metabolic health. Blood-based steroid assays are informative but invasive and reflect only short-term fluctuations. We compared serum a…
View article: SUN-203 Regulation Of Adrenal Androgen Production By Thyroid Hormones: Insights From The H295R Cell Model And Pediatric CAH Patients
SUN-203 Regulation Of Adrenal Androgen Production By Thyroid Hormones: Insights From The H295R Cell Model And Pediatric CAH Patients Open
Disclosure: P. Augsburger: None. T. Du Toit: None. S. Smit: None. C.E. Flueck: None. Introduction: Thyroid hormones (THs) play an essential role in the development, cellular differentiation and metabolism of the human body. Although TH act…
View article: OR32-08 Longitudinal Urinary Profiles of Glucocorticoid Precursors and Metabolites During the First Postnatal Year in Preterm Infants Born <30 Weeks of Gestation
OR32-08 Longitudinal Urinary Profiles of Glucocorticoid Precursors and Metabolites During the First Postnatal Year in Preterm Infants Born <30 Weeks of Gestation Open
Disclosure: T. Kuiri-Hänninen: None. C.E. Flueck: None. S. Silvennoinen: None. U. Sankilampi: None. Context. The fetal zone of the adrenal cortex remains active in preterm (PT) infants to term equivalent age (TEA), and then involutes. In a…
View article: Finding Early Biomarkers to Prevent Unfavorable Long-Term Health Outcomes after Premature Adrenarche: A Multicenter Prospective Cohort Study Protocol
Finding Early Biomarkers to Prevent Unfavorable Long-Term Health Outcomes after Premature Adrenarche: A Multicenter Prospective Cohort Study Protocol Open
Introduction: Adrenarche is a prepubertal developmental phase in humans characterized by increasing levels of adrenal androgens in circulation. While its regulation and biological significance remain poorly understood, the earlier onset of…
View article: Prevalence of differences of sex development among pediatric endocrine care centers in Switzerland from 2000-2019
Prevalence of differences of sex development among pediatric endocrine care centers in Switzerland from 2000-2019 Open
Objective Reliable data on prevalence of differences of sex development (DSD) are lacking. We aimed to estimate population-based prevalence of DSD among pediatric endocrine care centers in Switzerland. Design Retrospective population-based…
View article: Landscape of Steroid Dynamics in Pregnancy: Insights From the Maternal-Placental-Fetal Unit and Placental Models
Landscape of Steroid Dynamics in Pregnancy: Insights From the Maternal-Placental-Fetal Unit and Placental Models Open
Recent advances in analytical methods have revolutionized our understanding of steroid biochemistry. The emergence of novel steroids such as 11-oxy androgens and 11-oxy progesterones has necessitated a reevaluation of steroid biosynthesis …
View article: Blood pressure and its associations in 554 children and young people with congenital adrenal hyperplasia
Blood pressure and its associations in 554 children and young people with congenital adrenal hyperplasia Open
Background Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) affects approximately 1 in 15 000 individuals. We leveraged the power of multicentre registry data to assess the trend and predictors of blood pressur…
View article: Ambiguous Genitalia Due to 3β-Hydroxysteroid Dehydrogenase Type 2 Deficiency: Clinical, Genetic, and Functional Characterization of Two Novel <i>HSD3B2</i> Variants
Ambiguous Genitalia Due to 3β-Hydroxysteroid Dehydrogenase Type 2 Deficiency: Clinical, Genetic, and Functional Characterization of Two Novel <i>HSD3B2</i> Variants Open
3β-Hydroxysteroid dehydrogenase 2 deficiency (3βHSD2D) is a rare form of congenital adrenal hyperplasia (CAH) with variable clinical presentation. We describe a 46, XY child with ambiguous genitalia and CAH without apparent adrenal insuffi…
View article: Disordered Electron Transfer: New Forms of Defective Steroidogenesis and Mitochondriopathy
Disordered Electron Transfer: New Forms of Defective Steroidogenesis and Mitochondriopathy Open
Most disorders of steroidogenesis, such as forms of congenital adrenal hyperplasia (CAH) are caused by mutations in genes encoding the steroidogenic enzymes and are often recognized clinically by cortisol deficiency, hyper- or hypo-androge…
View article: Population-Based Study of Rare Coding Variants in <i>NR5A1</i>/SF-1
Population-Based Study of Rare Coding Variants in <i>NR5A1</i>/SF-1 Open
Background Steroidogenic Factor 1/Nuclear Receptor Subfamily 5 Group A Member 1 (SF-1/NR5A1) is critical for the development and function of sex organs, influencing steroidogenesis and reproduction. While rare deleterious NR5A1/SF-1 varian…
View article: 12203 FDXR Variants Cause Adrenal Insufficiency And Atypical Sexual Development
12203 FDXR Variants Cause Adrenal Insufficiency And Atypical Sexual Development Open
Disclosure: E. Pignatti: None. J. Slone: None. M. Gomez-Cano: None. T.M. Campbell: None. J. Vu: None. K. Sauter: None. A.V. Pandey: None. M. Alonso-Riaño: None. F. Martínez-Azorín: None. D. Neilson: None. N. Longo: None. T. Du Toit: None. …
View article: Temporal Trends in Acute Adrenal Insufficiency Events in Children With Congenital Adrenal Hyperplasia During 2019-2022
Temporal Trends in Acute Adrenal Insufficiency Events in Children With Congenital Adrenal Hyperplasia During 2019-2022 Open
Background It is unclear whether targeted monitoring of acute adrenal insufficiency (AI) related adverse events (AE) such as sick day episodes (SDEs) and hospitalization rate in congenital adrenal hyperplasia (CAH) is associated with a cha…
View article: THU207 11-oxygenated Androgens Are Strongly Associated With Treatment Quality In Children With Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
THU207 11-oxygenated Androgens Are Strongly Associated With Treatment Quality In Children With Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency Open
Disclosure: O. Abawi: None. T. Du Toit: None. G. Sommer: None. C.D. Vögel: None. M. Groessl: None. U. Halbsguth: None. S.E. Hannema: None. C. de Bruin: None. E. Charmandari: None. E.L. van den Akker: None. C.E. Flueck: None. Introduction: …
View article: FRI382 High Androgen And Progesterone Metabolite Concentrations In Naturally Matured Follicles Are Concurrent With High Serum Anti-Müllerian Hormone Concentrations
FRI382 High Androgen And Progesterone Metabolite Concentrations In Naturally Matured Follicles Are Concurrent With High Serum Anti-Müllerian Hormone Concentrations Open
Disclosure: T. Du Toit: None. M. Von Wolff: None. A.C. Swart: None. M. Groessl: None. C.E. Flueck: None. Infertility in women is routinely evaluated with the assessment of circulating steroid levels. Profiling steroid levels in follicular …
View article: THU208 Predicting Treatment Quality Assessment Of Children With Congenital Adrenal Hyperplasia Using 24h Urine Metabolomics Profiling And A Machine Learning-assisted Approach
THU208 Predicting Treatment Quality Assessment Of Children With Congenital Adrenal Hyperplasia Using 24h Urine Metabolomics Profiling And A Machine Learning-assisted Approach Open
Disclosure: O. Abawi: None. G. Sommer: None. M. Groessl: None. U. Halbsguth: None. S.E. Hannema: None. C. de Bruin: None. E. Charmandari: None. E.L. van den Akker: None. A.B. Leichtle: None. C.E. Flueck: None. Introduction: Current treatme…
View article: OR19-07 Metformin Inhibits Activation of the Melanocortin Receptor 2 and 3 in Vitro, a Possible Mechanism for Its Anti-Androgenic and Weight Balancing Effects in Vivo
OR19-07 Metformin Inhibits Activation of the Melanocortin Receptor 2 and 3 in Vitro, a Possible Mechanism for Its Anti-Androgenic and Weight Balancing Effects in Vivo Open
Metformin is recommended as one of the first-line drugs for the treatment of type 2 diabetes and the metabolic syndrome. In addition to its insulin sensitizing effects, it has been shown to attenuate androgen excess in women with polycysti…
View article: SUN-073 Urine Steroid Profile of Girls with Premature Adrenarche
SUN-073 Urine Steroid Profile of Girls with Premature Adrenarche Open
Background: Adrenarche describes the development of the human adrenal cortex when the zona reticularis increases the synthesis of C19 steroids (DHEA/-S). Girls with premature adrenarche have a higher risk to develop adverse outcomes includ…
View article: MON-219 In Silico and in Vitro Studies of Human 5α-Reductase Type II Variants in Search for Activating Variants Explaining Androgen Excess Reveal New Loss-Of-Function Variants
MON-219 In Silico and in Vitro Studies of Human 5α-Reductase Type II Variants in Search for Activating Variants Explaining Androgen Excess Reveal New Loss-Of-Function Variants Open
Background: Androgens are steroid hormones necessary for human sex development. Testosterone (T) and the more potent dihydrotestosterone (DHT) are maybe the best known androgens, which exert their effect by binding and activating the andro…