Rao Fu
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View article: Applications of artificial intelligence in cancer immunotherapy: a frontier review on enhancing treatment efficacy and safety
Applications of artificial intelligence in cancer immunotherapy: a frontier review on enhancing treatment efficacy and safety Open
Cancer immunotherapy represents a major breakthrough in oncology, particularly with immune checkpoint inhibitors (ICIs) and CAR-T cell therapies. Despite improved outcomes, challenges such as immune-related adverse events (irAEs) and treat…
View article: The pharmacy graduate global competence evaluation scale (PGGCES): a nationwide study in China
The pharmacy graduate global competence evaluation scale (PGGCES): a nationwide study in China Open
To improve GC, universities should prioritize enhancing students' global competence through reading foreign language materials and interacting with international scholars in daily teaching. Additionally, under resource-limited conditions, …
View article: Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma
Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma Open
Introduction Small nucleolar RNA (snoRNA) mediates RNA modifications, including 2′-O-methylation (Nm) and pseudouridine (Ψ), which has been proven to impact tumor progression. However, the role of snoRNA in the epigenetics of tumors remain…
View article: Highly Elastic, Biodegradable Polyester-Based Citrate Rubber for 3D Printing in Regenerative Engineering
Highly Elastic, Biodegradable Polyester-Based Citrate Rubber for 3D Printing in Regenerative Engineering Open
Highly elastic and 3D-printable degradable elastomers are advantageous for many biomedical applications. Herein, we report the synthesis of a biodegradable citrate rubber poly(tetrahydrofuran-co-citrate-co-hydroxyl telechelic natural rubbe…
View article: Administration of a combination of COX-2/TGF-β1 siRNAs induces hypertrophic scar fibroblast apoptosis through a TP53 mediated caspase pathway
Administration of a combination of COX-2/TGF-β1 siRNAs induces hypertrophic scar fibroblast apoptosis through a TP53 mediated caspase pathway Open
Hypertrophic scar (HTS) formation is a pathological fibrotic skin disease, with no satisfactory treatments available currently. Inducing apoptosis of HTS-derived fibroblasts (HSFs) are becoming promising approaches. In this research, we ai…
View article: 3D Printing of Multiscale Scaffolds with Microtopography for Guiding Tissue Organization and Regeneration
3D Printing of Multiscale Scaffolds with Microtopography for Guiding Tissue Organization and Regeneration Open
Engineering biomaterial scaffolds with multiscale structures, integrating anatomically accurate macroscale architecture (millimeters to centimeters) with microtopographic features (sub-microns to tens of microns), is critical for guiding c…
View article: HOXA9 promotes proliferation, metastasis and prevents apoptosis in hepatocellular carcinoma
HOXA9 promotes proliferation, metastasis and prevents apoptosis in hepatocellular carcinoma Open
HOXA9 is dramatically upregulated in hepatocellular carcinoma and predicts poor prognosis. Besides, HOXA9 promoted proliferation and metastasis and prevented apoptosis in vitro, which is regulated by Ribosomal protein RPL38 in HCC.
View article: Improving Survival in Sepsis: Optimizing Treatment Duration with Polymyxin-B Immobilized Hemoperfusion—A Comprehensive Network Meta-Analysis
Improving Survival in Sepsis: Optimizing Treatment Duration with Polymyxin-B Immobilized Hemoperfusion—A Comprehensive Network Meta-Analysis Open
Background and objectives: Sepsis and septic shock are critical health emergencies with high morbidity and mortality rates, often triggered by infections. The study investigates Polymyxin B-immobilized fiber column hemoperfusion (PMX-HP) a…
View article: SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47
SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47 Open
Accumulating studies highlight that dysregulated E3 ubiquitin ligases are associated with the onset and advancement of cancers. Nevertheless, the impact and mechanism of most E3 ubiquitin ligases on tumorigenesis and tumor metastasis remai…
View article: A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis
A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis Open
While studies highlighting a correlation between periodontitis and CA, our comprehensive analysis does not corroborate a causal association between periodontitis and CA. Further research is needed to elucidate other potential shared mechan…
View article: Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior
Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior Open
The rise in additive manufacturing (AM) offers myriad opportunities for 3D printed polymeric vascular scaffolds, such as customization and on‐the‐spot manufacturing, in vivo biodegradation, incorporation of drugs to prevent restenosis, and…
View article: CharacterMixer: Rig-Aware Interpolation of 3D Characters
CharacterMixer: Rig-Aware Interpolation of 3D Characters Open
We present CharacterMixer, a system for blending two rigged 3D characters with different mesh and skeleton topologies while maintaining a rig throughout interpolation. CharacterMixer also enables interpolation during motion for such charac…
View article: Negative pressure device-assisted autologous fat grafting: A case report
Negative pressure device-assisted autologous fat grafting: A case report Open
This report describes a novel technique for improving depressed scars using negative pressure suction-assisted autologous fat grafting. A 35-year-old woman presented with a 20-year history of bilateral central buttock concavities, causing …
View article: A Novel Combined Method for Measuring the Three-Dimensional Rotational Angle of a Spherical Joint
A Novel Combined Method for Measuring the Three-Dimensional Rotational Angle of a Spherical Joint Open
To improve the measurement accuracy of the three-dimensional rotation angle of a spherical joint, a novel approach is proposed in this study, which combines magnetic detection by a Hall sensor and surface feature identification by an eddy …
View article: AnyHome: Open-Vocabulary Generation of Structured and Textured 3D Homes
AnyHome: Open-Vocabulary Generation of Structured and Textured 3D Homes Open
Inspired by cognitive theories, we introduce AnyHome, a framework that translates any text into well-structured and textured indoor scenes at a house-scale. By prompting Large Language Models (LLMs) with designed templates, our approach co…
View article: A Novel Combined Method for Measuring the Three-Dimensional Rotational Angle of Spherical Joint
A Novel Combined Method for Measuring the Three-Dimensional Rotational Angle of Spherical Joint Open
To improve the measurement accuracy of three-dimensional rotation angle of the spherical joint, a novel approach is proposed in this study, which combines the magnetic detection by Hall sensor and surface feature identification by eddy cur…
View article: 3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty
3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty Open
Fully bioresorbable vascular scaffolds (BVSs) were designed to overcome the limitations of metallic drug-eluting stents (DESs). However, current polymer-based BVSs, such as Abbott’s Absorb, the only US FDA-approved BVS, struggle with incre…
View article: Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior
Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior Open
The rise in additive manufacturing (AM) offers myriad opportunities for 3D-printed polymeric vascular scaffolds, such as customization and on-the-spot manufacturing, in vivo biodegradation, incorporation of drugs to prevent restenosis, and…
View article: Administration of a Combination of COX-2/TGF-β1 siRNAs Induces Hypertrophic Scar Fibroblast Apoptosis through a TP53 mediated Caspase Pathway
Administration of a Combination of COX-2/TGF-β1 siRNAs Induces Hypertrophic Scar Fibroblast Apoptosis through a TP53 mediated Caspase Pathway Open
Hypertrophic scar (HTS) formation is a pathological fibrotic skin disease, with no satisfactory treatments available currently. Inducing apoptosis of HTS-derived fibroblasts (HSFs) are becoming promising approaches. In this research, we ai…
View article: Single-celled metasurface for labeled vortex beam generator
Single-celled metasurface for labeled vortex beam generator Open
Vortex light is a unique beam characterized by a spiral phase as it propagates. A fundamental parameter of vortex light is the topological charge, which determines the amount of angular momentum and plays a crucial role in tailoring its be…
View article: Patch-Wise Point Cloud Generation: A Divide-and-Conquer Approach
Patch-Wise Point Cloud Generation: A Divide-and-Conquer Approach Open
A generative model for high-fidelity point clouds is of great importance in synthesizing 3d environments for applications such as autonomous driving and robotics. Despite the recent success of deep generative models for 2d images, it is no…
View article: RETRACTED ARTICLE: Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis
RETRACTED ARTICLE: Brief literature review and comprehensive bioinformatics analytics unravel the potential mechanism of curcumin in the treatment of periodontitis Open
Objective Periodontitis is a chronic oral disease prevalent worldwide, and natural products are recommended as adjunctive therapy due to their minor side effects. Curcumin, a widely used ancient compound, has been reported to possess thera…
View article: A decade of progress: bibliometric analysis of trends and hotspots in oral microbiome research (2013-2022)
A decade of progress: bibliometric analysis of trends and hotspots in oral microbiome research (2013-2022) Open
Background Over the past decade, a plethora of studies have delved into the oral microbiome. Our objective was to evaluate the trends in oral microbiome research employing a quantitative approach. Materials and methods We extracted clinica…
View article: Oral microbiota may affect osteoradionecrosis following radiotherapy for head and neck cancer
Oral microbiota may affect osteoradionecrosis following radiotherapy for head and neck cancer Open
Background: Osteoradionecrosis (ORN) is a serious complication of radiotherapy for head and neck cancer (HNC). However, its etiology and pathogenesis have not been completely elucidated. Recent studies suggest the involvement of the oral m…
View article: Integrated transcriptomic and metabolomic analysis of cortical neurons reveals dysregulated lipid metabolism, enhanced glycolysis and activated HIF-1 signaling pathways in acute hypoxia
Integrated transcriptomic and metabolomic analysis of cortical neurons reveals dysregulated lipid metabolism, enhanced glycolysis and activated HIF-1 signaling pathways in acute hypoxia Open
The brain is the main oxygen-consuming organ and is vulnerable to ischemic shock or insufficient blood perfusion. Brain hypoxia has a persistent and detrimental effect on resident neurons. Previous studies have identified alterations in ge…