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View article: Breast-milk Lacticaseibacillus gasseri FN136 alleviates DSS-induced ulcerative colitis through microbiota-independent metabolite–host interactions
Breast-milk Lacticaseibacillus gasseri FN136 alleviates DSS-induced ulcerative colitis through microbiota-independent metabolite–host interactions Open
Chronic, relapsing colonic inflammation defines ulcerative colitis (UC) and heightens long-term colorectal cancer risk. Probiotics, proven beneficial, have emerged as a promising adjunctive strategy for UC management. We conducted a two-ti…
View article: SGLT2 inhibitors as a novel senotherapeutic approach
SGLT2 inhibitors as a novel senotherapeutic approach Open
Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues and organs with aging contribute to many chronic diseases, mainly through the secretion of a pro-inflammatory senescen…
View article: ACE inhibitory casein peptide lowers blood pressure and reshapes gut microbiota in a randomized double blind placebo controlled trial
ACE inhibitory casein peptide lowers blood pressure and reshapes gut microbiota in a randomized double blind placebo controlled trial Open
Casein-derived peptides have been shown to reduce blood pressure in animal studies, but evidence from human trials remains limited. This study aimed to investigate the antihypertensive effect and possible mechanisms of a hydrolyzed casein …
View article: 2’-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation
2’-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation Open
2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota and immune system. However, the microbiota of infants with atopic dermatitis (AD) often has difficult…
View article: The protective effect of <i>Limosilactobacillus reuteri</i> against gestational diabetes mellitus through restoring intestinal microbiota homeostasis and attenuating inflammation in mice
The protective effect of <i>Limosilactobacillus reuteri</i> against gestational diabetes mellitus through restoring intestinal microbiota homeostasis and attenuating inflammation in mice Open
Limosilactobacillus reuteri QS01 is potential probiotic isolated from the intestinal microbiota of healthy women in early pregnancy. In the current study, we examined whether QS01 can prevent gestational diabetes mellitus (GDM) in an enhan…
View article: Maternal supplementation with Limosilactobacillus reuteri FN041 for preventing infants with atopic dermatitis: study protocol for a randomized controlled trial
Maternal supplementation with Limosilactobacillus reuteri FN041 for preventing infants with atopic dermatitis: study protocol for a randomized controlled trial Open
Background Atopic dermatitis (AD) has increased rapidly with rapid urbanization; however, the treatment options for AD are lacking because the commonly used therapies can only alleviate symptoms. Limosilactobacillus reuteri (L. reuteri), F…
View article: Front Cover: Breast Milk‐Derived <i>Limosilactobacillus reuteri</i> Prevents Atopic Dermatitis in Mice via Activating Retinol Absorption and Metabolism in Peyer's Patches
Front Cover: Breast Milk‐Derived <i>Limosilactobacillus reuteri</i> Prevents Atopic Dermatitis in Mice via Activating Retinol Absorption and Metabolism in Peyer's Patches Open
Mol. Nutr. Food Res. 2023, 67, 202200444 DOI: 10.1002/mnfr.202200444 Limosilactobacillus reuteri Fn041 is a breast milk-derived probiotic from agricultural and pastoral areas. Eczema is prevented in mice pups when Fn041 is administrated to…
View article: Limosilactobacillus reuteri FN041 prevents atopic dermatitis in pup mice by remodeling the ileal microbiota and regulating gene expression in Peyer’s patches after vertical transmission
Limosilactobacillus reuteri FN041 prevents atopic dermatitis in pup mice by remodeling the ileal microbiota and regulating gene expression in Peyer’s patches after vertical transmission Open
Objectives Limosilactobacillus reuteri FN041 is a potential probiotic bacterium isolated from breast milk in traditional farming and pastoral areas of China. The purpose of this study was to investigate the optimal intervention mode and po…
View article: The Antidepressant Effect of Deoiled Sunflower Seeds on Chronic Unpredictable Mild Stress in Mice Through Regulation of Microbiota–Gut–Brain Axis
The Antidepressant Effect of Deoiled Sunflower Seeds on Chronic Unpredictable Mild Stress in Mice Through Regulation of Microbiota–Gut–Brain Axis Open
Objectives Sunflower seeds provide tryptophan-rich proteins with the potential to protect against depression. Tryptophan is a precursor of serotonin and a substrate for the production of indole derivatives by gut microbiota. This study aim…
View article: Prevention of High-Fat Diet-Induced Hypercholesterolemia by Lactobacillus reuteri Fn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions
Prevention of High-Fat Diet-Induced Hypercholesterolemia by Lactobacillus reuteri Fn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions Open
Objectives: Lactobacillus reuteri Fn041 (Fn041) is a probiotic isolated from immunoglobulin A coated microbiota in the human breast milk of Gannan in China with a low incidence of hypercholesterolemia. This study aims to explore the role a…
View article: Sex-dependent modulation of immune development in mice by secretory IgA–coated Lactobacillus reuteri isolated from breast milk
Sex-dependent modulation of immune development in mice by secretory IgA–coated Lactobacillus reuteri isolated from breast milk Open
Lactobacilli, commonly present in human breast milk, appear to colonize the neonatal gut and provide protection to infants against various infections, thereby promoting immune development. This study examined the potential probiotic role o…
View article: Co-occurence of Secretory Immunoglobulin A-Coated Bacteria in Maternal Gut, Breast Milk, and Infant Gut in Humans
Co-occurence of Secretory Immunoglobulin A-Coated Bacteria in Maternal Gut, Breast Milk, and Infant Gut in Humans Open
BackgroundGut microbiota promote and maintain infant health. Vertical transmission of bacteria from the maternal gut through breast milk to an infant is an important source of microbial colonisation in human offspring. However, the causati…
View article: Dietary resveratrol attenuated colitis and modulated gut microbiota in dextran sulfate sodium-treated mice
Dietary resveratrol attenuated colitis and modulated gut microbiota in dextran sulfate sodium-treated mice Open
Dietary resveratrol altered the microbial composition and restored microbial community diversity in colitic mice, which was associated with the suppression of colitis in the mice.
View article: IgA-Targeted Lactobacillus jensenii Modulated Gut Barrier and Microbiota in High-Fat Diet-Fed Mice
IgA-Targeted Lactobacillus jensenii Modulated Gut Barrier and Microbiota in High-Fat Diet-Fed Mice Open
IgA-coated Lactobacillus live in the mucous layer of the human or mammalian intestine in close proximity to epithelial cells. They act as potential probiotics for functional food development, but their physiological regulation has not yet …
View article: Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice
Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice Open
RSV prevented HFD-induced endotoxemia, oxidative stress, and gut microbiota change.
View article: The gastrointestinal fate of limonin and its effect on gut microbiota in mice
The gastrointestinal fate of limonin and its effect on gut microbiota in mice Open
After oral administration, the abundance of limonin was measured in GI tract and its impact on gut microbiota was determined.
View article: Comparison of the Efficacy of Different Drugs on Non-Motor Symptoms of Parkinson’s Disease: a Network Meta-Analysis
Comparison of the Efficacy of Different Drugs on Non-Motor Symptoms of Parkinson’s Disease: a Network Meta-Analysis Open
Background/Aims: A network meta-analysis is used to compare the efficacy of ropinirole, rasagiline, rotigotine, entacapone, apomorphine, pramipexole, sumanirole, bromocriptine, piribedil and levodopa, with placebo as a control, for non-mot…
View article: Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora
Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora Open
Our results indicated that degraded bacterial genomic DNA was mainly released by Gram-negative bacteria, especially Bacteroidales-S24-7 and Stenotrophomonas genus in gut mucus of mice. They decreased pro-inflammatory activity compared to t…