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View article: PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study
PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study Open
View article: Global transfusion practices in septic patients in the intensive care unit: insights from the <scp>InPUT</scp> ‐study sub‐analysis
Global transfusion practices in septic patients in the intensive care unit: insights from the <span>InPUT</span> ‐study sub‐analysis Open
Background Transfusion practices among intensive care unit (ICU) patients with sepsis vary widely. While restrictive hemoglobin thresholds for red blood cell (RBC) transfusion are well studied, the indications and thresholds for platelet a…
View article: Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study
Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study Open
Objective: There is a lack of comprehensive international data regarding platelet transfusion practices in the ICU. This study aimed to evaluate the current occurrence rate of platelet transfusion in the ICU and provide an overview of plat…
View article: Factors affecting voriconazole pharmacokinetic variability in critically ill patients: a systematic review
Factors affecting voriconazole pharmacokinetic variability in critically ill patients: a systematic review Open
Background The efficacy and toxicity of voriconazole, a broad-spectrum antifungal agent, are correlated with its trough concentration (C trough ). Patients hospitalised in the intensive care unit (ICU) frequently experience inad…
View article: Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study
Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study Open
View article: Guidelines for the management of emergencies and critical illness in pediatric and adult patients with sickle cell disease
Guidelines for the management of emergencies and critical illness in pediatric and adult patients with sickle cell disease Open
Forty-two questions were evaluated concerning management of emergencies and critical illnesses in paediatric and adult patients with sickle cell disease. The assessment covered the following areas: patient referral, vaso-occlusive crisis, …
View article: Reversal of antithrombotics in the critically ill: An international online survey
Reversal of antithrombotics in the critically ill: An international online survey Open
This survey shows variability in the reported clinical approaches to reverse antithrombotic agents in the ICU. The majority of hospitals included do not have a specific protocol for antithrombotic agents reversal emphasizing the need for I…
View article: Epidemiology and prediction of non-targeted bacteria by the filmarray pneumonia plus panel in culture-positive ventilator-associated pneumonia: a retrospective multicentre analysis
Epidemiology and prediction of non-targeted bacteria by the filmarray pneumonia plus panel in culture-positive ventilator-associated pneumonia: a retrospective multicentre analysis Open
Background Ventilator-associated pneumonia (VAP) is a prevalent nosocomial infection in intensive care units (ICUs) with significant impacts on patient outcomes and healthcare costs. Multiplex PCR could allow for personalized empirical tre…
View article: The impact of red blood cells storage duration on the development of acute kidney injury: A secondary analysis of the <scp>TRANSFUSE</scp> multicenter randomized controlled trial
The impact of red blood cells storage duration on the development of acute kidney injury: A secondary analysis of the <span>TRANSFUSE</span> multicenter randomized controlled trial Open
Background Red blood cell (RBC) transfusion is associated with an increased risk of acute kidney injury (AKI). The extent to which RBC storage affects this association is unclear. We aimed to evaluate the association between storage durati…
View article: Thrombocytopenia in the intensive care unit: diagnosis and management
Thrombocytopenia in the intensive care unit: diagnosis and management Open
Background This narrative review aims to describe the epidemiology and aetiologies of thrombocytopenia in critically ill patients, the bleeding risk assessment in thrombocytopenic patients, and provide an update on platelet transfusion ind…
View article: Plasma transfusion in the intensive care unit
Plasma transfusion in the intensive care unit Open
Background Current guidelines discourage prophylactic plasma use in non‐bleeding patients. This study assesses global plasma transfusion practices in the intensive care unit (ICU) and their alignment with current guidelines. Study Design a…
View article: Are we on the verge of a paradigm shift in transfusion decision-making?
Are we on the verge of a paradigm shift in transfusion decision-making? Open
View article: Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19
Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19 Open
View article: Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants Open
View article: Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis
Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis Open
Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacteral…
View article: Care of the critically ill begins in the emergency medicine setting
Care of the critically ill begins in the emergency medicine setting Open
International audience
View article: Anti-Factor-Xa and Activated Partial Thromboplastin Time Concordance and Outcomes in Adults Undergoing Extracorporeal Membrane Oxygenation: A Secondary Analysis of the Pilot Low-Dose Heparin in Critically Ill Patients Undergoing Extracorporeal Membrane Oxygenation Randomized Trial
Anti-Factor-Xa and Activated Partial Thromboplastin Time Concordance and Outcomes in Adults Undergoing Extracorporeal Membrane Oxygenation: A Secondary Analysis of the Pilot Low-Dose Heparin in Critically Ill Patients Undergoing Extracorporeal Membrane Oxygenation Randomized Trial Open
OBJECTIVES: To determine the concordance between activated partial thromboplastin time (aPTT) and anti-factor-Xa (anti-Xa) in adults undergoing extracorporeal membrane oxygenation (ECMO) and to identify the factors associated with discorda…
View article: Red Blood Cell Transfusion in the Intensive Care Unit
Red Blood Cell Transfusion in the Intensive Care Unit Open
Importance Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little is known about how these thre…
View article: Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study
Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study Open
Background Response to prophylactic platelet transfusion is suspected to be inconsistent in critically ill patients questioning how to optimize transfusion practices. This study aimed to describe prophylactic platelet transfusion response,…
View article: The place of new antibiotics for Gram-negative bacterial infections in intensive care: report of a consensus conference
The place of new antibiotics for Gram-negative bacterial infections in intensive care: report of a consensus conference Open
View article: Postoperative transfusion hemoglobin threshold and functional recovery after high‐risk oncologic surgery: A randomized controlled pilot study
Postoperative transfusion hemoglobin threshold and functional recovery after high‐risk oncologic surgery: A randomized controlled pilot study Open
Background Robust evidence to inform best transfusion management after major oncologic surgery, where postoperative recovery might impact treatment regimens for cancer, is lacking. We conducted a study to validate the feasibility of a larg…
View article: Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study
Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study Open
Background Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs were under intense pressure. We aimed t…
View article: Postoperative Transfusion Haemoglobin Threshold and Functional Recovery after High Risk Oncologic Surgery: A Randomized Controlled Pilot Study
Postoperative Transfusion Haemoglobin Threshold and Functional Recovery after High Risk Oncologic Surgery: A Randomized Controlled Pilot Study Open
View article: Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study
Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study Open
View article: Ten actions to achieve gender equity among intensivists: the French Society of Intensive Care (FICS) model
Ten actions to achieve gender equity among intensivists: the French Society of Intensive Care (FICS) model Open
View article: Early prone positioning in acute respiratory distress syndrome related to COVID-19: a propensity score analysis from the multicentric cohort COVID-ICU network—the ProneCOVID study
Early prone positioning in acute respiratory distress syndrome related to COVID-19: a propensity score analysis from the multicentric cohort COVID-ICU network—the ProneCOVID study Open
View article: Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals
Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals Open
View article: Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores
Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores Open
View article: Nationwide retrospective study of critically ill adults with sickle cell disease in France
Nationwide retrospective study of critically ill adults with sickle cell disease in France Open
View article: Clinical spectrum and risk factors for mortality among seawater and freshwater critically ill drowning patients: a French multicenter study
Clinical spectrum and risk factors for mortality among seawater and freshwater critically ill drowning patients: a French multicenter study Open