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151P Tumor organoid-derived TIL therapy for colorectal cancer Open
Colorectal cancer (CRC) represents ∼7% of new cancer cases and 11% of cancer deaths worldwide. Tumor-Infiltrating Lymphocyte (TIL) immunotherapy is efficacious against melanoma, but its potency in epithelial cancers such as CRC remains inc…
Legends for Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Supplemental figure legends also include brief methods where appropriate.
Data from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific…
Data from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific…
Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Supplemental figures include the RSPO gene expression analysis for CRC models, the in vitro testing of anti-RSPO antibodies on RSPO-negative tumors, the IHC analysis of anti-RSPO3+chemo-treated ovarian tumors, the LGR, ZNRF3, and RNF43 gen…
Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Supplemental figures include the RSPO gene expression analysis for CRC models, the in vitro testing of anti-RSPO antibodies on RSPO-negative tumors, the IHC analysis of anti-RSPO3+chemo-treated ovarian tumors, the LGR, ZNRF3, and RNF43 gen…
Legends for Figures S1-S7 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Supplemental figure legends also include brief methods where appropriate.
Tables S1-S3 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Supplemental Tables include a list and brief description of xenograft models used in the study, the RSPO1-4 gene expression profile and beta-catenin activation status of all xenograft models, and the microarray analysis for 4 CRC xenograft…
Tables S1-S3 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Supplemental Tables include a list and brief description of xenograft models used in the study, the RSPO1-4 gene expression profile and beta-catenin activation status of all xenograft models, and the microarray analysis for 4 CRC xenograft…
Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma Open
PURPOSE Effective treatment options are limited for patients with advanced (metastatic or unresectable) melanoma who progress after immune checkpoint inhibitors and targeted therapies. Adoptive cell therapy using tumor-infiltrating lymphoc…
PF447 IOVANCE PERIPHERAL BLOOD LYMPHOCYTES (PBL): A POTENTIAL CELL THERAPY STRATEGY FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA Open
Background: Adoptive cell therapy (ACT) using tumor infiltrating lymphocytes (TIL) and chimeric antigen receptor (CAR) T cells is at the forefront in the treatment of patients with solid tumors and hematological malignancies. Success of AC…
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death Open
WNT antagonism displays marked synergy with taxane chemotherapy and reverses taxane-induced enrichment of cancer stem cells.
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Open
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific…