Claire Debarnot
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View article: The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives
The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives Open
Heparanase 1 (HPSE1) is a unique endoglycosidase responsible for the enzymatic cleavage of heparan sulfate, thereby playing important functions in cancer processes. In contrast, the structurally related Heparanase 2 (HPSE2) lacks catalytic…
View article: Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1 Open
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cell…
View article: Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1
Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1 Open
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cell…
View article: Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity
Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity Open
View article: Substrate binding mode and catalytic mechanism of human heparan sulfate <scp>d</scp> -glucuronyl C5 epimerase
Substrate binding mode and catalytic mechanism of human heparan sulfate <span>d</span> -glucuronyl C5 epimerase Open
Heparan sulfate (HS) is a linear, complex polysaccharide that modulates the biological activities of proteins through binding sites made by a series of Golgi-localized enzymes. Of these, glucuronyl C5-epimerase (Glce) catalyzes C5-epimeriz…
View article: Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity
Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity Open
Henipaviruses are severe human pathogens responsible for severe encephalitis. Their V protein is a key player in the evasion of the host innate immune response. We have previously reported a biophysical characterization of the Henipavirus …
View article: Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold
Nanoscale Architecture of the Axon Initial Segment Reveals an Organized and Robust Scaffold Open
The axon initial segment (AIS), located within the first 30 μm of the axon, has two essential roles in generating action potentials and maintaining axonal identity. AIS assembly depends on a ßIV-spectrin/ankyrin G scaffold, but its macromo…
View article: <scp>CK</scp>2‐regulated schwannomin‐interacting protein <scp>IQCJ</scp>‐<scp>SCHIP</scp>‐1 association with AnkG contributes to the maintenance of the axon initial segment
<span>CK</span>2‐regulated schwannomin‐interacting protein <span>IQCJ</span>‐<span>SCHIP</span>‐1 association with AnkG contributes to the maintenance of the axon initial segment Open
The axon initial segment ( AIS ) plays a central role in electrogenesis and in the maintenance of neuronal polarity. Its molecular organization is dependent on the scaffolding protein ankyrin (Ank) G and is regulated by kinases. For exampl…