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View article: A new biofunctionalized and micropatterned PDMS is able to promote stretching induced human myotube maturation
A new biofunctionalized and micropatterned PDMS is able to promote stretching induced human myotube maturation Open
We use laser printing on organic–inorganic material and PDMS to study mechanical stress effect on human muscle cells. This model improves cell alignment and provide insights into muscle cell behavior under stress.
View article: Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair
Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair Open
Bone tissue engineering seeks to develop treatment approaches for nonhealing and large bone defects. An ideal biodegradable scaffold will induce and support bone formation. The current study examines bone augmentation in critical‐sized bon…
View article: A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials
A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials Open
While it is well understood that peptides can greatly improve cell-material interactions, it is often challenging to determine the concentration of the peptide which decorates a material. Herein, we describe a straightforward method using …
View article: Using Laponite to Deliver BMP‐2 for Bone Tissue Engineering – In Vitro, Chorioallantoic Membrane Assay and Murine Subcutaneous Model Validation
Using Laponite to Deliver BMP‐2 for Bone Tissue Engineering – In Vitro, Chorioallantoic Membrane Assay and Murine Subcutaneous Model Validation Open
Fracture non‐union occurs due to various factors, leading to the development of potentially substantial bone defects. While autograft and allograft are the current gold standards for non‐union fractures, challenges related to availability …
View article: Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model
Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite® to deliver BMP-2 in an ovine femoral condyle defect model Open
Biomaterial-based approaches for bone regeneration seek to explore alternative strategies to repair non-healing fractures and critical-sized bone defects. Fracture non-union occurs due to a number of factors resulting in the formation of b…
View article: Capacitive Biosensor Based on a Peptide Hybrid Substrate for the Detection of MMP-13 in Chronic Wounds
Capacitive Biosensor Based on a Peptide Hybrid Substrate for the Detection of MMP-13 in Chronic Wounds Open
This work focuses on a capacitive biosensor based on a hydride peptide for the detection of MMP-13. Indeed, the enzyme MMP-13 is a remarkable indicator of inflammation in chronic wounds. To achieve specific detection of this enzyme, a meta…
View article: Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite<sup>®</sup>to deliver BMP-2 in an ovine femoral condyle defect model
Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite<sup>®</sup>to deliver BMP-2 in an ovine femoral condyle defect model Open
Biomaterial-based approaches for bone regeneration seek to explore alternative strategies to repair non-healing fractures and critical-sized bone defects. Fracture non-union occurs due to a number of factors resulting in the formation of b…
View article: Bioactive coatings on 3D printed polycaprolactone scaffolds for bone regeneration: a novel murine femur defect model for examination of the biomaterial capacity for repair
Bioactive coatings on 3D printed polycaprolactone scaffolds for bone regeneration: a novel murine femur defect model for examination of the biomaterial capacity for repair Open
Bone tissue engineering is a rapidly advancing field that seeks to develop efficacious approaches for treating non-healing fractures and large bone defects. Healing complications arise due to trauma, disease, infection, aseptic loosening o…
View article: Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite™ to deliver BMP-2 for bone tissue engineering – progression through<i>in vitro</i>, chorioallantoic membrane assay and murine subcutaneous model validation
Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite™ to deliver BMP-2 for bone tissue engineering – progression through<i>in vitro</i>, chorioallantoic membrane assay and murine subcutaneous model validation Open
Fracture non-union occurs as a consequence of various factors, leading to the development of potentially substantial bone defects. Biomaterial-based approaches for bone regeneration aim to explore alternative strategies to repair non-heali…
View article: Bioactive coatings on 3D printed scaffolds for bone regeneration: Translation from<i>in vitro</i>to<i>in vivo</i>models and the impact of material properties and growth factor concentration
Bioactive coatings on 3D printed scaffolds for bone regeneration: Translation from<i>in vitro</i>to<i>in vivo</i>models and the impact of material properties and growth factor concentration Open
Bone tissue engineering is a rapidly advancing field that seeks to develop new functional bone tissue, harnessing materials for application in bone defects which may fail to heal without intervention, as seen in critical-sized bone defects…
View article: Silylated biomolecules: Versatile components for bioinks
Silylated biomolecules: Versatile components for bioinks Open
Physical hydrogels prepared from natural biopolymers are the most popular components for bioinks. However, to improve the mechanical properties of the network, in particular its durability for long-lasting tissue engineering applications o…
View article: Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant <i>Staphylococcus aureus</i> (MRSA) Infection
Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant <i>Staphylococcus aureus</i> (MRSA) Infection Open
Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria‐acti…
View article: Design and clinical application of injectable hydrogels for musculoskeletal therapy
Design and clinical application of injectable hydrogels for musculoskeletal therapy Open
Musculoskeletal defects are an enormous healthcare burden and source of pain and disability for individuals. With an aging population, the proportion of individuals living with these medical indications will increase. Simultaneously, there…
View article: Synthesis and Evaluation of Novel Ring‐Strained Noncanonical Amino Acids for Residue‐Specific Bioorthogonal Reactions in Living Cells
Synthesis and Evaluation of Novel Ring‐Strained Noncanonical Amino Acids for Residue‐Specific Bioorthogonal Reactions in Living Cells Open
Bioorthogonal reactions are ideally suited to selectively modify proteins in complex environments, even in vivo . Kinetics and product stability of these reactions are crucial parameters to evaluate their usefulness for specific applicatio…
View article: amTCO, a new<i>trans</i>-cyclooctene derivative to study drug-target interactions in cells
amTCO, a new<i>trans</i>-cyclooctene derivative to study drug-target interactions in cells Open
We provide a new tagging entity for click chemistry to perform improved drug binding assays in intact cells.
View article: 1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells
1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells Open
Click probes have enabled a thorough study of drug interactions in relevant disease models. Proper design of the probes, including the choice of the click moiety coupled to the drug, is crucial to ensure good performance and broad applicat…
View article: 1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells
1-(Aminomethyl)-Trans-Cyclooct-4-Ene, a New TCO Derivative for Target Visualization and Target Engagement Measurement in Cells Open
Click probes have enabled a thorough study of drug interactions in relevant disease models. Proper design of the probes, including the choice of the click moiety coupled to the drug, is crucial to ensure good performance and broad applicat…
View article: Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials
Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials Open
A simple and efficient way to synthesize peptide‐containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid‐catalyzed copolymerization of dichlorodimethylsilane,…
View article: Silica particles with a quercetin–R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus
Silica particles with a quercetin–R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus Open
Particles generated by biomimetic silica precipitation with a quercetin–R5 peptide enter the nucleus of HT-29 cells without inducing toxicity.
View article: Self-mineralization and assembly of a bis-silylated Phe–Phe pseudodipeptide to a structured bioorganic–inorganic material
Self-mineralization and assembly of a bis-silylated Phe–Phe pseudodipeptide to a structured bioorganic–inorganic material Open
Self-mineralization of a hybrid peptide building block with neither structure directing agents nor inorganic salts yields nanostructured materials.
View article: Inorganic polymerization: an attractive route to biocompatible hybrid hydrogels
Inorganic polymerization: an attractive route to biocompatible hybrid hydrogels Open
The sol–gel process is one of the main techniques leading to hybrid hydrogels that can be used in a wide scope of applications, especially in the biomedical field.
View article: Sol-gel and peptides: an attractive route to unprecedented biomaterials
Sol-gel and peptides: an attractive route to unprecedented biomaterials Open
Affording biological properties to a material is one of the challenges the chemists have to tackle, to improve the efficiency of existing devices and also to propose new biomaterials.Most of synthetic approaches to obtain functional materi…
View article: Modular bioink for 3D printing of biocompatible hydrogels: sol–gel polymerization of hybrid peptides and polymers
Modular bioink for 3D printing of biocompatible hydrogels: sol–gel polymerization of hybrid peptides and polymers Open
Inorganic polymerization as a cross-linking method for 3D printing of PEG–peptide hydrogels.