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View article: Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology Open
Multiple-system atrophy (MSA) is a rapidly progressive neurodegenerative disease of unknown cause, typically affecting individuals aged 50-60 years and leading to death within a decade1-3. It is characterized by glial cytoplasmic inclusion…
View article: Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology Open
Summary Paragraph Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease of unknown cause, typically affecting individuals aged 50–60 and leading to death within a decade 1–3 . It is characterized by glial cytopla…
View article: N-formylation modifies membrane damage associated to PSMα3 interfacial fibrillation
N-formylation modifies membrane damage associated to PSMα3 interfacial fibrillation Open
The virulence of Staphylococcus aureus, a multi-drug resistant pathogen, notably depends on the expression of the phenol soluble modulins α3 (PSMα3) peptides, able to self-assemble into amyloid-like cross-α fibrils. Despite remarkable adva…
View article: N-Formylation modifies membrane damage associated with PSMα3 interfacial fibrillation
N-Formylation modifies membrane damage associated with PSMα3 interfacial fibrillation Open
N-Formylation and oligomeric entities, formed along amyloid fibrillation, are critical for PSMα3 to induce lipid-dependent membrane damage.
View article: Interaction of full-length Tau with negatively charged lipid membranes leads to polymorphic aggregates
Interaction of full-length Tau with negatively charged lipid membranes leads to polymorphic aggregates Open
The Tau protein strongly binds to phosphatidylserine membranes, with partial membrane disruption and formation of polymorphic aggregates.
View article: Bioactive hydrogels based on lysine dendrigrafts as crosslinkers: tailoring elastic properties to influence hMSC osteogenic differentiation
Bioactive hydrogels based on lysine dendrigrafts as crosslinkers: tailoring elastic properties to influence hMSC osteogenic differentiation Open
Optimizing hydrogels for tissue engineering with multivalent crosslinking lysine dendrigrafts.
View article: Controlling differentiation of stem cells <i>via</i> bioactive disordered cues
Controlling differentiation of stem cells <i>via</i> bioactive disordered cues Open
A micro-, nano-structured bioactive surface, mimicking the extracellular matrix, acts like a magician in promoting the differentiation of adult stem cells into osteoblasts and osteocytes.
View article: Actin Bundle Nanomechanics and Organization Are Modulated by Macromolecular Crowding and Electrostatic Interactions
Actin Bundle Nanomechanics and Organization Are Modulated by Macromolecular Crowding and Electrostatic Interactions Open
The structural and mechanical properties of actin bundles are essential to eukaryotic cells, aiding in cell motility and mechanical support of the plasma membrane. Bundle formation occurs in crowded intracellular environments composed of v…
View article: Interaction of Tau construct K18 with model lipid membranes
Interaction of Tau construct K18 with model lipid membranes Open
AFM imaging of model membranes of controlled composition in interaction with Tau construct K18 showed PIP2 induced K18 fibrillization.
View article: <i>Staphylococcus aureus</i> binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis
<i>Staphylococcus aureus</i> binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis Open
Significance Staphylococcus aureus colonizes skin of patients with atopic dermatitis (AD), increasing disease severity. Colonization involves bacterial adhesion to skin corneocytes, and elucidating the molecular basis of interactions gover…
View article: High Speed AFM and NanoInfrared Spectroscopy Investigation of Aβ1–42 Peptide Variants and Their Interaction With POPC/SM/Chol/GM1 Model Membranes
High Speed AFM and NanoInfrared Spectroscopy Investigation of Aβ1–42 Peptide Variants and Their Interaction With POPC/SM/Chol/GM1 Model Membranes Open
Due to an aging population, neurodegenerative diseases such as Alzheimer's disease (AD) have become a major health issue. In the case of AD, Aβ1 - 42 peptides have been identified as one of the markers of the disease with the formation of …
View article: High speed atomic force microscopy to investigate the interactions between toxic Aβ1-42 peptides and model membranes in real time: impact of the membrane composition
High speed atomic force microscopy to investigate the interactions between toxic Aβ1-42 peptides and model membranes in real time: impact of the membrane composition Open
Due to an aging population, neurodegenerative diseases have become a major health issue, the most common being Alzheimer’s disease. The mechanisms leading to neuronal loss still remain unclear but recent studies suggest that soluble Aβ oli…
View article: The microbial adhesive arsenal deciphered by atomic force microscopy
The microbial adhesive arsenal deciphered by atomic force microscopy Open
Microbes employ a variety of strategies to adhere to abiotic and biotic surfaces, as well as host cells.
View article: Localized incorporation of outer membrane components in the pathogen <i>Brucella abortus</i>
Localized incorporation of outer membrane components in the pathogen <i>Brucella abortus</i> Open
The zoonotic pathogen Brucella abortus is part of the Rhizobiales, which are alpha-proteobacteria displaying unipolar growth. Here, we show that this bacterium exhibits heterogeneity in its outer membrane composition, with clusters of roug…
View article: Bacterial Sexuality at the Nanoscale
Bacterial Sexuality at the Nanoscale Open
Understanding the basic mechanisms of bacterial sexuality is an important topic in current microbiology and biotechnology. While classical methods used to study gene transfer provide information on whole cell populations, nanotechnologies …
View article: Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels
Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels Open
The bacterial pathogen Staphylococcus aureus plays an important role in atopic dermatitis (AD), a chronic disorder that mostly affects children. Colonization of the skin of AD patients by S. aureus exacerbates the disease, but the molecula…
View article: Force-Induced Strengthening of the Interaction between <i>Staphylococcus aureus</i> Clumping Factor B and Loricrin
Force-Induced Strengthening of the Interaction between <i>Staphylococcus aureus</i> Clumping Factor B and Loricrin Open
Bacterial pathogens that colonize host surfaces are subjected to physical stresses such as fluid flow and cell surface contacts. How bacteria respond to such mechanical cues is an important yet poorly understood issue. Staphylococcus aureu…
View article: Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis
Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis Open
Staphylococcus aureus skin infection is a frequent and recurrent problem in children with the common inflammatory skin disease atopic dermatitis (AD). S. aureus colonizes the skin of the majority of children with AD and exacerbates the dis…
View article: Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC
Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC Open
Significance The bacterial pathogen Staphylococcus aureus shows a remarkable ability to aggregate, thereby contributing to the formation of cellular communities that are difficult to eradicate. In this study, we dissect the homophilic inte…